Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Thenner S.
Data de Publicação: 2017
Outros Autores: Silva, Anderson G.M. da, Oliveira, Lucas C. de, Silva, Adalberto M. da, Teixeira, Róbson R., Camargo, Pedro H.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: https://doi.org/10.1016/j.tetlet.2017.01.005
http://www.locus.ufv.br/handle/123456789/21384
Resumo: We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions.
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spelling Rodrigues, Thenner S.Silva, Anderson G.M. daOliveira, Lucas C. deSilva, Adalberto M. daTeixeira, Róbson R.Camargo, Pedro H.C.2018-08-23T13:42:21Z2018-08-23T13:42:21Z2017-02-080040-4039https://doi.org/10.1016/j.tetlet.2017.01.005http://www.locus.ufv.br/handle/123456789/21384We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions.engTetrahedron Lettersvolume 58, número 6, páginas 590-595, fevereiro 2017Elsevier Ltd.info:eu-repo/semantics/openAccessCu2O spheresWell-defined and monodisperse Cu2OWell-defined and monodisperse Cu2O spheresAzide-alkyne click reactionsCopper(I)-catalyzed azide-alkyne cycloadditionCu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf2774482https://locus.ufv.br//bitstream/123456789/21384/1/artigo.pdfb4baa571f1811b31913657e326a0f5d7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/21384/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5153https://locus.ufv.br//bitstream/123456789/21384/3/artigo.pdf.jpg529685b4447a6d821309cb0b0e7e766fMD53123456789/213842018-08-23 23:00:57.496oai:locus.ufv.br:123456789/21384Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-08-24T02:00:57LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
title Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
spellingShingle Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
Rodrigues, Thenner S.
Cu2O spheres
Well-defined and monodisperse Cu2O
Well-defined and monodisperse Cu2O spheres
Azide-alkyne click reactions
Copper(I)-catalyzed azide-alkyne cycloaddition
title_short Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
title_full Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
title_fullStr Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
title_full_unstemmed Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
title_sort Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
author Rodrigues, Thenner S.
author_facet Rodrigues, Thenner S.
Silva, Anderson G.M. da
Oliveira, Lucas C. de
Silva, Adalberto M. da
Teixeira, Róbson R.
Camargo, Pedro H.C.
author_role author
author2 Silva, Anderson G.M. da
Oliveira, Lucas C. de
Silva, Adalberto M. da
Teixeira, Róbson R.
Camargo, Pedro H.C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Thenner S.
Silva, Anderson G.M. da
Oliveira, Lucas C. de
Silva, Adalberto M. da
Teixeira, Róbson R.
Camargo, Pedro H.C.
dc.subject.pt-BR.fl_str_mv Cu2O spheres
Well-defined and monodisperse Cu2O
Well-defined and monodisperse Cu2O spheres
Azide-alkyne click reactions
Copper(I)-catalyzed azide-alkyne cycloaddition
topic Cu2O spheres
Well-defined and monodisperse Cu2O
Well-defined and monodisperse Cu2O spheres
Azide-alkyne click reactions
Copper(I)-catalyzed azide-alkyne cycloaddition
description We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions.
publishDate 2017
dc.date.issued.fl_str_mv 2017-02-08
dc.date.accessioned.fl_str_mv 2018-08-23T13:42:21Z
dc.date.available.fl_str_mv 2018-08-23T13:42:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.1016/j.tetlet.2017.01.005
http://www.locus.ufv.br/handle/123456789/21384
dc.identifier.issn.none.fl_str_mv 0040-4039
identifier_str_mv 0040-4039
url https://doi.org/10.1016/j.tetlet.2017.01.005
http://www.locus.ufv.br/handle/123456789/21384
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv volume 58, número 6, páginas 590-595, fevereiro 2017
dc.rights.driver.fl_str_mv Elsevier Ltd.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Elsevier Ltd.
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Tetrahedron Letters
publisher.none.fl_str_mv Tetrahedron Letters
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
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