Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1016/j.tetlet.2017.01.005 http://www.locus.ufv.br/handle/123456789/21384 |
Resumo: | We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions. |
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Rodrigues, Thenner S.Silva, Anderson G.M. daOliveira, Lucas C. deSilva, Adalberto M. daTeixeira, Róbson R.Camargo, Pedro H.C.2018-08-23T13:42:21Z2018-08-23T13:42:21Z2017-02-080040-4039https://doi.org/10.1016/j.tetlet.2017.01.005http://www.locus.ufv.br/handle/123456789/21384We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions.engTetrahedron Lettersvolume 58, número 6, páginas 590-595, fevereiro 2017Elsevier Ltd.info:eu-repo/semantics/openAccessCu2O spheresWell-defined and monodisperse Cu2OWell-defined and monodisperse Cu2O spheresAzide-alkyne click reactionsCopper(I)-catalyzed azide-alkyne cycloadditionCu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf2774482https://locus.ufv.br//bitstream/123456789/21384/1/artigo.pdfb4baa571f1811b31913657e326a0f5d7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/21384/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5153https://locus.ufv.br//bitstream/123456789/21384/3/artigo.pdf.jpg529685b4447a6d821309cb0b0e7e766fMD53123456789/213842018-08-23 23:00:57.496oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-08-24T02:00:57LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
title |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
spellingShingle |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions Rodrigues, Thenner S. Cu2O spheres Well-defined and monodisperse Cu2O Well-defined and monodisperse Cu2O spheres Azide-alkyne click reactions Copper(I)-catalyzed azide-alkyne cycloaddition |
title_short |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
title_full |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
title_fullStr |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
title_full_unstemmed |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
title_sort |
Cu2O spheres as an efficient source of catalytic Cu(I) species for performing azide-alkyne click reactions |
author |
Rodrigues, Thenner S. |
author_facet |
Rodrigues, Thenner S. Silva, Anderson G.M. da Oliveira, Lucas C. de Silva, Adalberto M. da Teixeira, Róbson R. Camargo, Pedro H.C. |
author_role |
author |
author2 |
Silva, Anderson G.M. da Oliveira, Lucas C. de Silva, Adalberto M. da Teixeira, Róbson R. Camargo, Pedro H.C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Thenner S. Silva, Anderson G.M. da Oliveira, Lucas C. de Silva, Adalberto M. da Teixeira, Róbson R. Camargo, Pedro H.C. |
dc.subject.pt-BR.fl_str_mv |
Cu2O spheres Well-defined and monodisperse Cu2O Well-defined and monodisperse Cu2O spheres Azide-alkyne click reactions Copper(I)-catalyzed azide-alkyne cycloaddition |
topic |
Cu2O spheres Well-defined and monodisperse Cu2O Well-defined and monodisperse Cu2O spheres Azide-alkyne click reactions Copper(I)-catalyzed azide-alkyne cycloaddition |
description |
We report herein the high yield synthesis of Cu2O spheres displaying well-defined shapes and monodisperse sizes that could be employed as the source of highly catalytic active Cu(I) species towards click reactions between several of alkynes and azides to produce a variety of 1,2,3-triazoles under ligand-free and ambient conditions (in an open reactor). The utilization of Cu2O spheres enabled superior performance as compared to a conventional protocol in which CuSO4 is employed in combination with sodium ascorbate as the catalyst system. In addition, the compounds were obtained in synthetically useful yields, and seven of them have not been previously reported. We believe the results reported herein shed new insights into the optimization of activity and versatility of click reactions towards the synthesis of target molecules in environmentally friendly conditions. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-02-08 |
dc.date.accessioned.fl_str_mv |
2018-08-23T13:42:21Z |
dc.date.available.fl_str_mv |
2018-08-23T13:42:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.tetlet.2017.01.005 http://www.locus.ufv.br/handle/123456789/21384 |
dc.identifier.issn.none.fl_str_mv |
0040-4039 |
identifier_str_mv |
0040-4039 |
url |
https://doi.org/10.1016/j.tetlet.2017.01.005 http://www.locus.ufv.br/handle/123456789/21384 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
volume 58, número 6, páginas 590-595, fevereiro 2017 |
dc.rights.driver.fl_str_mv |
Elsevier Ltd. info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Elsevier Ltd. |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Tetrahedron Letters |
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Tetrahedron Letters |
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LOCUS Repositório Institucional da UFV |
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