Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UNIGRANRIO |
Texto Completo: | http://localhost:8080/tede/handle/tede/103 |
Resumo: | Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse. |
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Tinoco, Eduardo Muniz BarrettoSilva, Denise Gomes daFalabella, Marcio Eduardo VieiraTeixeira, Henrique Guilherme CastroGuaitolini, Roberto Luiz2016-11-16T13:09:33Z2009-07-08GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias.http://localhost:8080/tede/handle/tede/103Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse.A halitose é, na grande maioria das vezes, um problema originado na cavidade oral e tem como principal contribuinte os compostos sulfurados voláteis (CSV), que são formados a partir da quebra de aminoácidos por bactérias orais. O objetivo desse estudo foi avaliar a capacidade de um novo dentifrício contendo dióxido de cloro em reduzir os níveis de CSV. Esse estudo consistiu de uma avaliação duplo-cega, randomizada, placebo-controlada e cruzada, de 10 voluntários, saudáveis, onde a halitose foi induzida através do bochecho de L-cisteína (6mM - pH 7,2). Três dentifrícios foram utilizados na forma de solução para bochecho, um teste (à base de dióxido de cloro), placebo (controle negativo) e digluconato de clorexidina a 0,12% (controle positivo). Para a aferição dos níveis de CSVs foi utilizado um Halímetro (Halimeter®, Interscan Corp., Chatsworth, CA, USA). Para cada dentifrício foram feitas 6 medições nos participantes: inicial, pós-cisteína, pós-bochecho, pós-1 hora, pós-2 horas, pós-3 horas. Todos os participantes utilizaram os três dentifrícios, e tiveram um período de washout de no mínimo quinze dias entre os bochechos das soluções. Após aferido os valores pelo halímetro em partes por bilhão (ppb), foi encontrada a taxa de redução dos níveis de CSVs, que consistia na subtração dos valores pós-bochecho, pós-1 hora, pós-2 horas, pós-3 horas, pelos valores pós-cisteína respectivos. O valor da taxa de redução dos níveis de CSVs foi dado em porcentagem. No período pós-bochecho, a taxa de redução do dentifrício teste foi superior ao placebo e inferior à clorexidina. Já no período pós-1 hora, pós-2 horas e pós-3 horas a taxa de redução do dentifrício teste foi similar à clorexidina, sendo ambas superiores estatisticamente ao placebo, concluindo-se que o dentifrício teste foi capaz de reduzir os níveis de compostos sulfurados voláteis quando comparado ao placebo, se comportando de forma similar à solução de clorexidina a 0.12% após 1, 2 e 3 horas ao bochecho.Submitted by Janser dos Santos Nascimento (janser.nascimento@unigranrio.com.br) on 2016-11-16T13:09:33Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberto Luiz Guaitolini.pdf: 1761577 bytes, checksum: 772d593ed53394f06bdfd968454a91fd (MD5)Made available in DSpace on 2016-11-16T13:09:33Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberto Luiz Guaitolini.pdf: 1761577 bytes, checksum: 772d593ed53394f06bdfd968454a91fd (MD5) Previous issue date: 2009-07-08CNPqapplication/pdfporUniversidade do Grande RioPrograma de Pós-Graduação em OdontologiaUNIGRANRIOBrasilUnigranrio::Odontologiahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessOdontologiaPeriodontiaHalitoseODONTOLOGIA::PERIODONTIAAvaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Biblioteca Digital de Teses e Dissertações da UNIGRANRIOinstname:Universidade do Grande Rio (UNIGRANRIO)instacron:UNIGRANRIOLICENSElicense.txtlicense.txttext/plain; charset=utf-81982http://localhost:8080/tede/bitstream/tede/103/1/license.txt4a50535e8405f611398e6e2d408dbd1bMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://localhost:8080/tede/bitstream/tede/103/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://localhost:8080/tede/bitstream/tede/103/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://localhost:8080/tede/bitstream/tede/103/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54ORIGINALRoberto Luiz Guaitolini.pdfRoberto Luiz Guaitolini.pdfapplication/pdf1761577http://localhost:8080/tede/bitstream/tede/103/5/Roberto+Luiz+Guaitolini.pdf772d593ed53394f06bdfd968454a91fdMD55tede/1032016-11-16 11:09:33.437oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.unigranrio.edu.br/PUBhttp://tede.unigranrio.edu.br/oai/requestrepositorio@instituicao.br||repositorio@instituicao.bropendoar:2016-11-16T13:09:33Biblioteca Digital de Teses e Dissertações da UNIGRANRIO - Universidade do Grande Rio (UNIGRANRIO)false |
dc.title.por.fl_str_mv |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
title |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
spellingShingle |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis Guaitolini, Roberto Luiz Odontologia Periodontia Halitose ODONTOLOGIA::PERIODONTIA |
title_short |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
title_full |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
title_fullStr |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
title_full_unstemmed |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
title_sort |
Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis |
author |
Guaitolini, Roberto Luiz |
author_facet |
Guaitolini, Roberto Luiz |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Tinoco, Eduardo Muniz Barretto |
dc.contributor.referee1.fl_str_mv |
Silva, Denise Gomes da |
dc.contributor.referee2.fl_str_mv |
Falabella, Marcio Eduardo Vieira |
dc.contributor.referee3.fl_str_mv |
Teixeira, Henrique Guilherme Castro |
dc.contributor.author.fl_str_mv |
Guaitolini, Roberto Luiz |
contributor_str_mv |
Tinoco, Eduardo Muniz Barretto Silva, Denise Gomes da Falabella, Marcio Eduardo Vieira Teixeira, Henrique Guilherme Castro |
dc.subject.por.fl_str_mv |
Odontologia Periodontia Halitose |
topic |
Odontologia Periodontia Halitose ODONTOLOGIA::PERIODONTIA |
dc.subject.cnpq.fl_str_mv |
ODONTOLOGIA::PERIODONTIA |
description |
Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-07-08 |
dc.date.accessioned.fl_str_mv |
2016-11-16T13:09:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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dc.identifier.citation.fl_str_mv |
GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias. |
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http://localhost:8080/tede/handle/tede/103 |
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GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias. |
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