Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis

Detalhes bibliográficos
Autor(a) principal: Guaitolini, Roberto Luiz
Data de Publicação: 2009
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UNIGRANRIO
Texto Completo: http://localhost:8080/tede/handle/tede/103
Resumo: Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse.
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spelling Tinoco, Eduardo Muniz BarrettoSilva, Denise Gomes daFalabella, Marcio Eduardo VieiraTeixeira, Henrique Guilherme CastroGuaitolini, Roberto Luiz2016-11-16T13:09:33Z2009-07-08GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias.http://localhost:8080/tede/handle/tede/103Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse.A halitose é, na grande maioria das vezes, um problema originado na cavidade oral e tem como principal contribuinte os compostos sulfurados voláteis (CSV), que são formados a partir da quebra de aminoácidos por bactérias orais. O objetivo desse estudo foi avaliar a capacidade de um novo dentifrício contendo dióxido de cloro em reduzir os níveis de CSV. Esse estudo consistiu de uma avaliação duplo-cega, randomizada, placebo-controlada e cruzada, de 10 voluntários, saudáveis, onde a halitose foi induzida através do bochecho de L-cisteína (6mM - pH 7,2). Três dentifrícios foram utilizados na forma de solução para bochecho, um teste (à base de dióxido de cloro), placebo (controle negativo) e digluconato de clorexidina a 0,12% (controle positivo). Para a aferição dos níveis de CSVs foi utilizado um Halímetro (Halimeter®, Interscan Corp., Chatsworth, CA, USA). Para cada dentifrício foram feitas 6 medições nos participantes: inicial, pós-cisteína, pós-bochecho, pós-1 hora, pós-2 horas, pós-3 horas. Todos os participantes utilizaram os três dentifrícios, e tiveram um período de washout de no mínimo quinze dias entre os bochechos das soluções. Após aferido os valores pelo halímetro em partes por bilhão (ppb), foi encontrada a taxa de redução dos níveis de CSVs, que consistia na subtração dos valores pós-bochecho, pós-1 hora, pós-2 horas, pós-3 horas, pelos valores pós-cisteína respectivos. O valor da taxa de redução dos níveis de CSVs foi dado em porcentagem. No período pós-bochecho, a taxa de redução do dentifrício teste foi superior ao placebo e inferior à clorexidina. Já no período pós-1 hora, pós-2 horas e pós-3 horas a taxa de redução do dentifrício teste foi similar à clorexidina, sendo ambas superiores estatisticamente ao placebo, concluindo-se que o dentifrício teste foi capaz de reduzir os níveis de compostos sulfurados voláteis quando comparado ao placebo, se comportando de forma similar à solução de clorexidina a 0.12% após 1, 2 e 3 horas ao bochecho.Submitted by Janser dos Santos Nascimento (janser.nascimento@unigranrio.com.br) on 2016-11-16T13:09:33Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Roberto Luiz Guaitolini.pdf: 1761577 bytes, checksum: 772d593ed53394f06bdfd968454a91fd (MD5)Made available in DSpace on 2016-11-16T13:09:33Z (GMT). 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dc.title.por.fl_str_mv Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
title Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
spellingShingle Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
Guaitolini, Roberto Luiz
Odontologia
Periodontia
Halitose
ODONTOLOGIA::PERIODONTIA
title_short Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
title_full Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
title_fullStr Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
title_full_unstemmed Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
title_sort Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis
author Guaitolini, Roberto Luiz
author_facet Guaitolini, Roberto Luiz
author_role author
dc.contributor.advisor1.fl_str_mv Tinoco, Eduardo Muniz Barretto
dc.contributor.referee1.fl_str_mv Silva, Denise Gomes da
dc.contributor.referee2.fl_str_mv Falabella, Marcio Eduardo Vieira
dc.contributor.referee3.fl_str_mv Teixeira, Henrique Guilherme Castro
dc.contributor.author.fl_str_mv Guaitolini, Roberto Luiz
contributor_str_mv Tinoco, Eduardo Muniz Barretto
Silva, Denise Gomes da
Falabella, Marcio Eduardo Vieira
Teixeira, Henrique Guilherme Castro
dc.subject.por.fl_str_mv Odontologia
Periodontia
Halitose
topic Odontologia
Periodontia
Halitose
ODONTOLOGIA::PERIODONTIA
dc.subject.cnpq.fl_str_mv ODONTOLOGIA::PERIODONTIA
description Halitosis is a problem caused in the vast majority of cases in the oral cavity and has as its main contributor to volatile sulfur compounds (VSC), which are formed from the break of amino acids by oral bacteria. The aim of this study is to assess the ability of toothpaste containing chlorine dioxide to reduce VSC levels. The study consisted of an evaluation randomized, double-blind, crossover, and placebo-controlled of 9 healthy volunteers, where the halitosis was induced through the rinse of L-cysteine (6mm - pH 7.2). Three toothpastes were used as a solution to rinse, a test (containing 0.3% cetylpyridinium chloride, 0.44% chlorine dioxide and 0.33% of sodium fluoride (NaF)), placebo (negative control) and digluconate chlorhexidine to 0.12% (positive control). Halimeter® (Halimeter ®, Interscan Corp.., Chatsworth, CA, USA) was used to measure the levels of VSC. For each toothpaste 6 measurements were made on participants: initial, post-cysteine, post-rinse, after 1 hour, after 2 hours, after 3 hours. All participants used the three different dentifrices, and had a minimum washout period of at least fifteen days between each study phase. Reduction rate means in VSC levels were calculated for each group subtracting post-cysteine values by the post-rinse values, and then normalized. Data analysis was done using Kruskal-Wallis and Student-Newman-Keuls tests and the -level was set at 0.05. The test product showed higher reduction rate in VSC levels immediately after the rinse, after 1 hour, after 2 hours and after 3 hours, when compared with placebo (p<0,05). In the period after 1 hour, after 2 hours and after 3 hours the reduction rate of test toothpaste was similar to chlorhexidine, both being statistically superior to placebo. In the period immediately after the rinse there is statistical difference between all solutions, with chlorhexidine showed higher reduction rate. Based on the results we can conclude that the toothpaste test based on chlorine dioxide was able to reduce levels of volatile sulfur compounds, are behaving in a manner similar to the solution of the 0.12% chlorhexidine after 1 hour, after 2 hours and 3 hours to rinse.
publishDate 2009
dc.date.issued.fl_str_mv 2009-07-08
dc.date.accessioned.fl_str_mv 2016-11-16T13:09:33Z
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dc.identifier.citation.fl_str_mv GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias.
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identifier_str_mv GUAITOLINI, Roberto Luiz. Avaliação clínica de um novo dentifrício na redução dos compostos sulfurados voláteis. 2009. 72 f. Dissertação (Mestrado em Odontologia) - Universidade do Grande Rio Prof. José de Souza Herdy", Duque de Caxias.
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