Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo

Detalhes bibliográficos
Autor(a) principal: Oliveira, Michel Anderson Galvão de
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UNIGRANRIO
Texto Completo: http://localhost:8080/tede/handle/tede/222
Resumo: The use of biomaterials in dental surgery has become an important area of research. This material can be used for the purpose of filling defects, replace portions bone, bone augmentation, facilitate or enhance the repair of bone defects by bone conduction, providing mechanical support to the membrane and stabilize the blood clot .The geometry of these biomaterials to promote invagination of blood vessels. For this, it needs to be porous and have interconnected macropores. The surface of bone substitutes are determined by their chemical composition, microporosity, surface roughness, crystallinity and crystal size.This study presents the results of histomorphometric use of three commercially available substitutes. The model of defects in the calvaria of rabbits used is well established in the literature, with consistent results. In this case, both the defects filled with the biomaterials showed better distribution in the newly formed bone , lower volume loss and reduced migration into the soft tissue defect , then the conclusion is that both bone substitutes showed used biocompatibility , not negatively affect the repair process. However, the synthetic biomaterial NanoSynt had higher levels of bone formation and maintenance of the defect when compared to materials BoneCeramic ® and Bio-Oss ® during the two periods in vivo in the present study (4 and 8 weeks).
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spelling Senna , Plinio MendesGranato, RodrigoVieira, Victor Talarico LealMarin, CharlesSotto Maior, Bruno SallesOliveira, Michel Anderson Galvão de2018-07-12T20:33:45Z2015-08-11Oliveira, Michel Anderson Galvão de. Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo. 2015. 28 f. Dissertação( Programa de Pós-Graduação em Odontologia) - Universidade do Grande Rio, Duque de Caxias.http://localhost:8080/tede/handle/tede/222The use of biomaterials in dental surgery has become an important area of research. This material can be used for the purpose of filling defects, replace portions bone, bone augmentation, facilitate or enhance the repair of bone defects by bone conduction, providing mechanical support to the membrane and stabilize the blood clot .The geometry of these biomaterials to promote invagination of blood vessels. For this, it needs to be porous and have interconnected macropores. The surface of bone substitutes are determined by their chemical composition, microporosity, surface roughness, crystallinity and crystal size.This study presents the results of histomorphometric use of three commercially available substitutes. The model of defects in the calvaria of rabbits used is well established in the literature, with consistent results. In this case, both the defects filled with the biomaterials showed better distribution in the newly formed bone , lower volume loss and reduced migration into the soft tissue defect , then the conclusion is that both bone substitutes showed used biocompatibility , not negatively affect the repair process. However, the synthetic biomaterial NanoSynt had higher levels of bone formation and maintenance of the defect when compared to materials BoneCeramic ® and Bio-Oss ® during the two periods in vivo in the present study (4 and 8 weeks).O uso de biomateriais em cirurgias odontológicas tornou-se uma importante área de pesquisa. Esses materiais podem ser utilizados com o objetivo de preencher defeitos, substituir porções ósseas, aumentar o tecido ósseo, facilitar ou melhorar o reparo dos defeitos ósseos pela osteocondução, fornecer suporte mecânico para membranas e estabilizar o coágulo sanguíneo. A geometria desses biomateriais deve favorecer a proliferação de vasos sanguíneos. Para isso, o mesmo precisa ser poroso, com macroporos interconectados. As características superficiais dos substitutos ósseos são determinadas pela sua composição química, microporosidade, rugosidade superficial, cristalinidade e tamanho do cristal.Este estudo apresenta os resultados histomorfométricos do uso de três substitutos comercialmente disponíveis. O modelo de defeitos em calvária de coelhos utilizado já está consolidado na literatura, com resultados consistentes. Neste caso, os defeitos preenchidos com os biomateriais, apresentaram melhor distribuição do tecido ósseo neoformado, menor perda de volume e menor migração de tecido mole para o interior do defeito, concluindo-se então que todos os substitutos ósseos utilizados apresentaram características de biocompatibilidade, não interferindo negativamente no processo de reparo. Entretanto, o biomaterial sintético NanoSynt apresentou maior nível de formação óssea e manutenção do espaço do defeito quando comparado aos materiais Boneceramic® e Bio-Oss® durante os dois períodos in vivo do presente estudo (4 e 8 semanas).Submitted by Patricia Vieira Silva (patricia.silva@unigranrio.com.br) on 2018-07-12T20:33:45Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Michel Anderson Galvão de Oliveira 2015.pdf: 1479195 bytes, checksum: 0dabe5a385c1b82fa59fe9634d051ca9 (MD5)Made available in DSpace on 2018-07-12T20:33:45Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Michel Anderson Galvão de Oliveira 2015.pdf: 1479195 bytes, checksum: 0dabe5a385c1b82fa59fe9634d051ca9 (MD5) Previous issue date: 2015-08-11application/pdfporUniversidade do Grande RioPrograma de Pós-Graduação em OdontologiaUNIGRANRIOBrasilUnigranrio::Odontologiahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessOdontologiaOsteoconduçãoRegeneração ósseaHistomorfometriaOdontologiaAvaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Biblioteca Digital de Teses e Dissertações da UNIGRANRIOinstname:Universidade do Grande Rio (UNIGRANRIO)instacron:UNIGRANRIOLICENSElicense.txtlicense.txttext/plain; charset=utf-81982http://localhost:8080/tede/bitstream/tede/222/1/license.txt4a50535e8405f611398e6e2d408dbd1bMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://localhost:8080/tede/bitstream/tede/222/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://localhost:8080/tede/bitstream/tede/222/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://localhost:8080/tede/bitstream/tede/222/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54ORIGINALMichel Anderson Galvão de Oliveira 2015.pdfMichel Anderson Galvão de Oliveira 2015.pdfapplication/pdf1479195http://localhost:8080/tede/bitstream/tede/222/5/Michel+Anderson+Galv%C3%A3o+de+Oliveira+2015.pdf0dabe5a385c1b82fa59fe9634d051ca9MD55tede/2222018-07-12 17:33:45.192oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.unigranrio.edu.br/PUBhttp://tede.unigranrio.edu.br/oai/requestrepositorio@instituicao.br||repositorio@instituicao.bropendoar:2018-07-12T20:33:45Biblioteca Digital de Teses e Dissertações da UNIGRANRIO - Universidade do Grande Rio (UNIGRANRIO)false
dc.title.por.fl_str_mv Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
title Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
spellingShingle Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
Oliveira, Michel Anderson Galvão de
Odontologia
Osteocondução
Regeneração óssea
Histomorfometria
Odontologia
title_short Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
title_full Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
title_fullStr Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
title_full_unstemmed Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
title_sort Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo
author Oliveira, Michel Anderson Galvão de
author_facet Oliveira, Michel Anderson Galvão de
author_role author
dc.contributor.advisor1.fl_str_mv Senna , Plinio Mendes
dc.contributor.advisor-co1.fl_str_mv Granato, Rodrigo
dc.contributor.referee1.fl_str_mv Vieira, Victor Talarico Leal
dc.contributor.referee2.fl_str_mv Marin, Charles
dc.contributor.referee3.fl_str_mv Sotto Maior, Bruno Salles
dc.contributor.author.fl_str_mv Oliveira, Michel Anderson Galvão de
contributor_str_mv Senna , Plinio Mendes
Granato, Rodrigo
Vieira, Victor Talarico Leal
Marin, Charles
Sotto Maior, Bruno Salles
dc.subject.por.fl_str_mv Odontologia
Osteocondução
Regeneração óssea
Histomorfometria
topic Odontologia
Osteocondução
Regeneração óssea
Histomorfometria
Odontologia
dc.subject.cnpq.fl_str_mv Odontologia
description The use of biomaterials in dental surgery has become an important area of research. This material can be used for the purpose of filling defects, replace portions bone, bone augmentation, facilitate or enhance the repair of bone defects by bone conduction, providing mechanical support to the membrane and stabilize the blood clot .The geometry of these biomaterials to promote invagination of blood vessels. For this, it needs to be porous and have interconnected macropores. The surface of bone substitutes are determined by their chemical composition, microporosity, surface roughness, crystallinity and crystal size.This study presents the results of histomorphometric use of three commercially available substitutes. The model of defects in the calvaria of rabbits used is well established in the literature, with consistent results. In this case, both the defects filled with the biomaterials showed better distribution in the newly formed bone , lower volume loss and reduced migration into the soft tissue defect , then the conclusion is that both bone substitutes showed used biocompatibility , not negatively affect the repair process. However, the synthetic biomaterial NanoSynt had higher levels of bone formation and maintenance of the defect when compared to materials BoneCeramic ® and Bio-Oss ® during the two periods in vivo in the present study (4 and 8 weeks).
publishDate 2015
dc.date.issued.fl_str_mv 2015-08-11
dc.date.accessioned.fl_str_mv 2018-07-12T20:33:45Z
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dc.identifier.citation.fl_str_mv Oliveira, Michel Anderson Galvão de. Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo. 2015. 28 f. Dissertação( Programa de Pós-Graduação em Odontologia) - Universidade do Grande Rio, Duque de Caxias.
dc.identifier.uri.fl_str_mv http://localhost:8080/tede/handle/tede/222
identifier_str_mv Oliveira, Michel Anderson Galvão de. Avaliação histomorfométrica de 3 substitutos ósseos em odontologia: estudo in vivo. 2015. 28 f. Dissertação( Programa de Pós-Graduação em Odontologia) - Universidade do Grande Rio, Duque de Caxias.
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dc.publisher.department.fl_str_mv Unigranrio::Odontologia
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