MECHANICAL ASPECTS OF A GROWING TUMOR

Detalhes bibliográficos
Autor(a) principal: M. Resende, Anna Claudia
Data de Publicação: 2017
Outros Autores: C. Almeida, Regina, L. Rocha, Heber, A. B. F. Lima, Ernesto
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Interdisciplinar de Pesquisa em Engenharia
Texto Completo: https://periodicos.unb.br/index.php/ripe/article/view/14415
Resumo: Abstract. Cell stresses have a key role on the tumor growth rate, the evolution pattern and on ECM synthesis and organization. In this work, we investigate the interplay between these complex biological phenomena. We develop a heterogeneous tumor growth model subjected to elastic deformation and matrix degradation and remodeling. We incorporate mechanical effects of the surrounding tissue on the growing tumor by assuming that the stress components must satisfy the conservation of linear momentum disregarding inertial effects. We investigate tumor differentiation, morphogenic evolution, and invasion through different feedback mechanism models. Numerical simulations are performed to highlight how mechanical properties of a tissue contribute to cancer progression.Keywords: Mathematical Model, Tumor Growth, Sensitivity Analysis, Mechanical Properties
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spelling MECHANICAL ASPECTS OF A GROWING TUMORAbstract. Cell stresses have a key role on the tumor growth rate, the evolution pattern and on ECM synthesis and organization. In this work, we investigate the interplay between these complex biological phenomena. We develop a heterogeneous tumor growth model subjected to elastic deformation and matrix degradation and remodeling. We incorporate mechanical effects of the surrounding tissue on the growing tumor by assuming that the stress components must satisfy the conservation of linear momentum disregarding inertial effects. We investigate tumor differentiation, morphogenic evolution, and invasion through different feedback mechanism models. Numerical simulations are performed to highlight how mechanical properties of a tissue contribute to cancer progression.Keywords: Mathematical Model, Tumor Growth, Sensitivity Analysis, Mechanical PropertiesPrograma de Pós-Graduação em Integridade de Materiais da Engenharia2017-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.unb.br/index.php/ripe/article/view/1441510.26512/ripe.v2i33.14415Revista Interdisciplinar de Pesquisa em Engenharia; Vol. 2 No. 33 (2016): COMPUTATIONAL MODELING OF CANCER AND COMPUTATIONAL PLASTICITY MONOTONIC AND CYCLIC APPLICATIONSRevista Interdisciplinar de Pesquisa em Engenharia; v. 2 n. 33 (2016): COMPUTATIONAL MODELING OF CANCER AND COMPUTATIONAL PLASTICITY MONOTONIC AND CYCLIC APPLICATIONS2447-6102reponame:Revista Interdisciplinar de Pesquisa em Engenhariainstname:Universidade de Brasília (UnB)instacron:UNBporhttps://periodicos.unb.br/index.php/ripe/article/view/14415/12726M. Resende, Anna ClaudiaC. Almeida, ReginaL. Rocha, HeberA. B. F. Lima, Ernestoinfo:eu-repo/semantics/openAccess2019-07-17T03:23:54Zoai:ojs.pkp.sfu.ca:article/14415Revistahttps://periodicos.unb.br/index.php/ripePUBhttps://periodicos.unb.br/index.php/ripe/oaianflor@unb.br2447-61022447-6102opendoar:2019-07-17T03:23:54Revista Interdisciplinar de Pesquisa em Engenharia - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv MECHANICAL ASPECTS OF A GROWING TUMOR
title MECHANICAL ASPECTS OF A GROWING TUMOR
spellingShingle MECHANICAL ASPECTS OF A GROWING TUMOR
M. Resende, Anna Claudia
title_short MECHANICAL ASPECTS OF A GROWING TUMOR
title_full MECHANICAL ASPECTS OF A GROWING TUMOR
title_fullStr MECHANICAL ASPECTS OF A GROWING TUMOR
title_full_unstemmed MECHANICAL ASPECTS OF A GROWING TUMOR
title_sort MECHANICAL ASPECTS OF A GROWING TUMOR
author M. Resende, Anna Claudia
author_facet M. Resende, Anna Claudia
C. Almeida, Regina
L. Rocha, Heber
A. B. F. Lima, Ernesto
author_role author
author2 C. Almeida, Regina
L. Rocha, Heber
A. B. F. Lima, Ernesto
author2_role author
author
author
dc.contributor.author.fl_str_mv M. Resende, Anna Claudia
C. Almeida, Regina
L. Rocha, Heber
A. B. F. Lima, Ernesto
description Abstract. Cell stresses have a key role on the tumor growth rate, the evolution pattern and on ECM synthesis and organization. In this work, we investigate the interplay between these complex biological phenomena. We develop a heterogeneous tumor growth model subjected to elastic deformation and matrix degradation and remodeling. We incorporate mechanical effects of the surrounding tissue on the growing tumor by assuming that the stress components must satisfy the conservation of linear momentum disregarding inertial effects. We investigate tumor differentiation, morphogenic evolution, and invasion through different feedback mechanism models. Numerical simulations are performed to highlight how mechanical properties of a tissue contribute to cancer progression.Keywords: Mathematical Model, Tumor Growth, Sensitivity Analysis, Mechanical Properties
publishDate 2017
dc.date.none.fl_str_mv 2017-08-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unb.br/index.php/ripe/article/view/14415
10.26512/ripe.v2i33.14415
url https://periodicos.unb.br/index.php/ripe/article/view/14415
identifier_str_mv 10.26512/ripe.v2i33.14415
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unb.br/index.php/ripe/article/view/14415/12726
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Programa de Pós-Graduação em Integridade de Materiais da Engenharia
publisher.none.fl_str_mv Programa de Pós-Graduação em Integridade de Materiais da Engenharia
dc.source.none.fl_str_mv Revista Interdisciplinar de Pesquisa em Engenharia; Vol. 2 No. 33 (2016): COMPUTATIONAL MODELING OF CANCER AND COMPUTATIONAL PLASTICITY MONOTONIC AND CYCLIC APPLICATIONS
Revista Interdisciplinar de Pesquisa em Engenharia; v. 2 n. 33 (2016): COMPUTATIONAL MODELING OF CANCER AND COMPUTATIONAL PLASTICITY MONOTONIC AND CYCLIC APPLICATIONS
2447-6102
reponame:Revista Interdisciplinar de Pesquisa em Engenharia
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Revista Interdisciplinar de Pesquisa em Engenharia
collection Revista Interdisciplinar de Pesquisa em Engenharia
repository.name.fl_str_mv Revista Interdisciplinar de Pesquisa em Engenharia - Universidade de Brasília (UnB)
repository.mail.fl_str_mv anflor@unb.br
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