Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Uint, Luciana
Data de Publicação: 2003
Outros Autores: Spósito, Andrei Carvalho, Brandizzi, Laura Ines Ventura, Yoshida, Vanda Mitie, Maranhão, Raul Cavalcante, Luz, Protásio Lemos da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/4025
Resumo: 3 f. : il.
id UNB_02a44e4b15233587dc66815d2a62f69b
oai_identifier_str oai:repositorio.unb.br:10482/4025
network_acronym_str UNB
network_name_str Repositório Institucional da UnB
repository_id_str
spelling Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery diseaseCoronariopatiasColesterolLipoproteínasArtérias3 f. : il.OBJECTIVE: The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD) and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS: Smooth muscle cells isolated from human aortas cultured and radiolabeled with ³H-cholesterol were loaded with cholesterol and incubated with increasing concentrations of HDL isolated from 13 CAD patients with low HDL-C (CAD group) or from 5 controls without CAD (C group). Efflux of cellular cholesterol was measured by cellular depletion of radiolabeled cholesterol and by the appearance of ³H-cholesterol into experimental medium expressed as a percentage of total labeled cholesterol. RESULTS: Cholesterol efflux increased with the amount of HDL present in the medium, and no difference was found between groups at various HDL protein concentrations: efflux was 28 ± 6.3 percent (C) and 25.5 ± 8.9 percent (CAD) with 25 mg/mL; 34 ± 4.3 percent (C) and 31.9 ± 6.6 percent (CD) with 50 mg/mL and 39.5 ± 3.5 percent (C) and 37.1 ± 4.4 percent (CAD) with 100 mg/mL, HDL. CONCLUSION: Because the HDL fraction of CAD patients with low HDL-C have normal ability to extract cholesterol from cells of the vessel wall, it is suggested that low HDL-C atherogenicity should be ascribed to diminished concentrations of HDL particles rather than to the qualitative properties of the HDL fraction (AU).Faculdade de Medicina (FMD)2010-03-26T13:35:34Z2010-03-26T13:35:34Z2003info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfUINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010.http://repositorio.unb.br/handle/10482/4025Uint, LucianaSpósito, Andrei CarvalhoBrandizzi, Laura Ines VenturaYoshida, Vanda MitieMaranhão, Raul CavalcanteLuz, Protásio Lemos dainfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-22T18:54:31Zoai:repositorio.unb.br:10482/4025Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-22T18:54:31Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
title Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
spellingShingle Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
Uint, Luciana
Coronariopatias
Colesterol
Lipoproteínas
Artérias
title_short Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
title_full Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
title_fullStr Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
title_full_unstemmed Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
title_sort Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
author Uint, Luciana
author_facet Uint, Luciana
Spósito, Andrei Carvalho
Brandizzi, Laura Ines Ventura
Yoshida, Vanda Mitie
Maranhão, Raul Cavalcante
Luz, Protásio Lemos da
author_role author
author2 Spósito, Andrei Carvalho
Brandizzi, Laura Ines Ventura
Yoshida, Vanda Mitie
Maranhão, Raul Cavalcante
Luz, Protásio Lemos da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Uint, Luciana
Spósito, Andrei Carvalho
Brandizzi, Laura Ines Ventura
Yoshida, Vanda Mitie
Maranhão, Raul Cavalcante
Luz, Protásio Lemos da
dc.subject.por.fl_str_mv Coronariopatias
Colesterol
Lipoproteínas
Artérias
topic Coronariopatias
Colesterol
Lipoproteínas
Artérias
description 3 f. : il.
publishDate 2003
dc.date.none.fl_str_mv 2003
2010-03-26T13:35:34Z
2010-03-26T13:35:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv UINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010.
http://repositorio.unb.br/handle/10482/4025
identifier_str_mv UINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010.
url http://repositorio.unb.br/handle/10482/4025
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
_version_ 1814508271773417472

Registros relacionados