Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/25982 https://dx.doi.org/10.1590/S0074-02762003000200003 |
Resumo: | This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalin-fixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively. |
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Rabelo-Santos, SHZeferino, LVilla, LLSobrinho, JPAmaral, RGMagalhães, AV2017-12-07T04:37:35Z2017-12-07T04:37:35Z2003Mem. Inst. Oswaldo Cruz,v.98,n.2,p.181-184,2003http://repositorio.unb.br/handle/10482/25982https://dx.doi.org/10.1590/S0074-02762003000200003This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalin-fixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively.Em processamentoInstituto Oswaldo Cruz, Ministério da SaúdeHuman papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehuman papillomaviruscervical cancercervical intraepithelial neoplasiapolymerase chain reactiondot blot hybridizationprevalenceGoiás (Estado)Brazilinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALv98n2a03.pdfapplication/pdf48067http://repositorio2.unb.br/jspui/bitstream/10482/25982/1/v98n2a03.pdf66e2434adb61880eade9903a5ec11b29MD51open access10482/259822023-10-06 16:45:22.333open accessoai:repositorio2.unb.br:10482/25982Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-10-06T19:45:22Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
title |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
spellingShingle |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil Rabelo-Santos, SH human papillomavirus cervical cancer cervical intraepithelial neoplasia polymerase chain reaction dot blot hybridization prevalence Goiás (Estado) Brazil |
title_short |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
title_full |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
title_fullStr |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
title_full_unstemmed |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
title_sort |
Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil |
author |
Rabelo-Santos, SH |
author_facet |
Rabelo-Santos, SH Zeferino, L Villa, LL Sobrinho, JP Amaral, RG Magalhães, AV |
author_role |
author |
author2 |
Zeferino, L Villa, LL Sobrinho, JP Amaral, RG Magalhães, AV |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rabelo-Santos, SH Zeferino, L Villa, LL Sobrinho, JP Amaral, RG Magalhães, AV |
dc.subject.keyword.pt_BR.fl_str_mv |
human papillomavirus cervical cancer cervical intraepithelial neoplasia polymerase chain reaction dot blot hybridization prevalence Goiás (Estado) Brazil |
topic |
human papillomavirus cervical cancer cervical intraepithelial neoplasia polymerase chain reaction dot blot hybridization prevalence Goiás (Estado) Brazil |
description |
This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalin-fixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:37:35Z |
dc.date.available.fl_str_mv |
2017-12-07T04:37:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Mem. Inst. Oswaldo Cruz,v.98,n.2,p.181-184,2003 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/25982 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S0074-02762003000200003 |
identifier_str_mv |
Mem. Inst. Oswaldo Cruz,v.98,n.2,p.181-184,2003 |
url |
http://repositorio.unb.br/handle/10482/25982 https://dx.doi.org/10.1590/S0074-02762003000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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UNB |
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Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
bitstream.url.fl_str_mv |
http://repositorio2.unb.br/jspui/bitstream/10482/25982/1/v98n2a03.pdf |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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