Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease
| Autor(a) principal: | |
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| Data de Publicação: | 2003 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UnB |
| Texto Completo: | http://repositorio.unb.br/handle/10482/4025 |
Resumo: | 3 f. : il. |
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Uint, LucianaSpósito, Andrei CarvalhoBrandizzi, Laura Ines VenturaYoshida, Vanda MitieMaranhão, Raul CavalcanteLuz, Protásio Lemos da2010-03-26T13:35:34Z2010-03-26T13:35:34Z2003UINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010.http://repositorio.unb.br/handle/10482/40253 f. : il.OBJECTIVE: The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD) and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS: Smooth muscle cells isolated from human aortas cultured and radiolabeled with ³H-cholesterol were loaded with cholesterol and incubated with increasing concentrations of HDL isolated from 13 CAD patients with low HDL-C (CAD group) or from 5 controls without CAD (C group). Efflux of cellular cholesterol was measured by cellular depletion of radiolabeled cholesterol and by the appearance of ³H-cholesterol into experimental medium expressed as a percentage of total labeled cholesterol. RESULTS: Cholesterol efflux increased with the amount of HDL present in the medium, and no difference was found between groups at various HDL protein concentrations: efflux was 28 ± 6.3 percent (C) and 25.5 ± 8.9 percent (CAD) with 25 mg/mL; 34 ± 4.3 percent (C) and 31.9 ± 6.6 percent (CD) with 50 mg/mL and 39.5 ± 3.5 percent (C) and 37.1 ± 4.4 percent (CAD) with 100 mg/mL, HDL. CONCLUSION: Because the HDL fraction of CAD patients with low HDL-C have normal ability to extract cholesterol from cells of the vessel wall, it is suggested that low HDL-C atherogenicity should be ascribed to diminished concentrations of HDL particles rather than to the qualitative properties of the HDL fraction (AU).Faculdade de Medicina (FMD)Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCoronariopatiasColesterolLipoproteínasArtériasBRAinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_CellularCholesterolEffluxMediatedHDL.pdfARTIGO_CellularCholesterolEffluxMediatedHDL.pdfapplication/pdf36292http://repositorio2.unb.br/jspui/bitstream/10482/4025/1/ARTIGO_CellularCholesterolEffluxMediatedHDL.pdf00dc48ec0169bd133282011d0c755cb8MD51open accessCC-LICENSElicense_urllicense_urltext/plain49http://repositorio2.unb.br/jspui/bitstream/10482/4025/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52open accesslicense_textlicense_textapplication/octet-stream19804http://repositorio2.unb.br/jspui/bitstream/10482/4025/3/license_text71892dada5d59e83859450f8db8a6410MD53open accesslicense_rdflicense_rdfapplication/octet-stream12170http://repositorio2.unb.br/jspui/bitstream/10482/4025/4/license_rdf28c18d8d50ea5f68c8c3d89546d38e8dMD54open accessLICENSElicense.txtlicense.txttext/plain1857http://repositorio2.unb.br/jspui/bitstream/10482/4025/5/license.txtc7c060029c0dae3a11b9edc9d7fbfec8MD55open accessTEXTARTIGO_CellularCholesterolEffluxMediatedHDL.pdf.txtARTIGO_CellularCholesterolEffluxMediatedHDL.pdf.txtExtracted texttext/plain14900http://repositorio2.unb.br/jspui/bitstream/10482/4025/6/ARTIGO_CellularCholesterolEffluxMediatedHDL.pdf.txtfb5b71e1ad634f0fb979712e96965978MD56open access10482/40252023-08-22 15:54:31.779open accessoai:repositorio2.unb.br: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 Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-22T18:54:31Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
| dc.title.en.fl_str_mv |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| title |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| spellingShingle |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease Uint, Luciana Coronariopatias Colesterol Lipoproteínas Artérias |
| title_short |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| title_full |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| title_fullStr |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| title_full_unstemmed |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| title_sort |
Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease |
| author |
Uint, Luciana |
| author_facet |
Uint, Luciana Spósito, Andrei Carvalho Brandizzi, Laura Ines Ventura Yoshida, Vanda Mitie Maranhão, Raul Cavalcante Luz, Protásio Lemos da |
| author_role |
author |
| author2 |
Spósito, Andrei Carvalho Brandizzi, Laura Ines Ventura Yoshida, Vanda Mitie Maranhão, Raul Cavalcante Luz, Protásio Lemos da |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Uint, Luciana Spósito, Andrei Carvalho Brandizzi, Laura Ines Ventura Yoshida, Vanda Mitie Maranhão, Raul Cavalcante Luz, Protásio Lemos da |
| dc.subject.keyword.en.fl_str_mv |
Coronariopatias Colesterol Lipoproteínas Artérias |
| topic |
Coronariopatias Colesterol Lipoproteínas Artérias |
| description |
3 f. : il. |
| publishDate |
2003 |
| dc.date.issued.fl_str_mv |
2003 |
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2010-03-26T13:35:34Z |
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2010-03-26T13:35:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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UINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010. |
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http://repositorio.unb.br/handle/10482/4025 |
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UINT, Luciana et al. Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease. Arquivo Brasileiro de Cardiologia, São Paulo, v. 81, n. 1, p. 39-41, 2003. Disponível em: <http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&src=google&base=LILACS〈=p&nextAction=lnk&exprSearch=341309&indexSearch=ID>. Acesso em: 15 mar. 2010. |
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