Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Detalhes bibliográficos
Autor(a) principal: Parize, Alexandre Luis
Data de Publicação: 2012
Outros Autores: Stulzer, Hellen Karine, Laranjeira, Mauro César Marghetti, Brighente, Inês Maria da Costa, Souza, Tereza Cristina Rozone de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/28331
https://dx.doi.org/10.1590/S0100-40422012000600011
Resumo: The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.
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spelling Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray dryingQuitosanaCurcuminaSecagemThe aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.Instituto de Química (IQ)Sociedade Brasileira de Química2017-12-07T04:58:41Z2017-12-07T04:58:41Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPARIZE, Alexandre Luis et al. Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying. Química Nova, São Paulo, v. 35, n. 6, p. 1127-1132, 2012. DOI: https://doi.org/10.1590/S0100-40422012000600011. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.http://repositorio.unb.br/handle/10482/28331https://dx.doi.org/10.1590/S0100-40422012000600011Química Nova - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.info:eu-repo/semantics/openAccessParize, Alexandre LuisStulzer, Hellen KarineLaranjeira, Mauro César MarghettiBrighente, Inês Maria da CostaSouza, Tereza Cristina Rozone deengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-09-23T11:48:47Zoai:repositorio.unb.br:10482/28331Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-09-23T11:48:47Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
title Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
spellingShingle Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
Parize, Alexandre Luis
Quitosana
Curcumina
Secagem
title_short Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
title_full Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
title_fullStr Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
title_full_unstemmed Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
title_sort Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying
author Parize, Alexandre Luis
author_facet Parize, Alexandre Luis
Stulzer, Hellen Karine
Laranjeira, Mauro César Marghetti
Brighente, Inês Maria da Costa
Souza, Tereza Cristina Rozone de
author_role author
author2 Stulzer, Hellen Karine
Laranjeira, Mauro César Marghetti
Brighente, Inês Maria da Costa
Souza, Tereza Cristina Rozone de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Parize, Alexandre Luis
Stulzer, Hellen Karine
Laranjeira, Mauro César Marghetti
Brighente, Inês Maria da Costa
Souza, Tereza Cristina Rozone de
dc.subject.por.fl_str_mv Quitosana
Curcumina
Secagem
topic Quitosana
Curcumina
Secagem
description The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.
publishDate 2012
dc.date.none.fl_str_mv 2012
2017-12-07T04:58:41Z
2017-12-07T04:58:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PARIZE, Alexandre Luis et al. Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying. Química Nova, São Paulo, v. 35, n. 6, p. 1127-1132, 2012. DOI: https://doi.org/10.1590/S0100-40422012000600011. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.
http://repositorio.unb.br/handle/10482/28331
https://dx.doi.org/10.1590/S0100-40422012000600011
identifier_str_mv PARIZE, Alexandre Luis et al. Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying. Química Nova, São Paulo, v. 35, n. 6, p. 1127-1132, 2012. DOI: https://doi.org/10.1590/S0100-40422012000600011. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600011&lng=en&nrm=iso&tlng=en. Acesso em: 22 out. 2020.
url http://repositorio.unb.br/handle/10482/28331
https://dx.doi.org/10.1590/S0100-40422012000600011
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
_version_ 1814508391443202048

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