Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model

Detalhes bibliográficos
Autor(a) principal: Semerene, Amélia Regina
Data de Publicação: 2004
Outros Autores: Lino Junior, Ruy de Souza, Oliveira, Jayrson Araújo, Magalhães, Albino Verçosa de, Stefani, Mariane Martins Araújo, Barbosa, Alverne Passos, Campos, Dulcinéa Maria Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/2808
http://dx.doi.org/10.1590/S0074-02762004000400009
Resumo: The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.
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spelling Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine modelHelmintoInfecçãoInflamaçãoThe goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.Faculdade de Medicina (FMD)2009-12-21T18:56:38Z2009-12-21T18:56:38Z2004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009.http://repositorio.unb.br/handle/10482/2808http://dx.doi.org/10.1590/S0074-02762004000400009Semerene, Amélia ReginaLino Junior, Ruy de SouzaOliveira, Jayrson AraújoMagalhães, Albino Verçosa deStefani, Mariane Martins AraújoBarbosa, Alverne PassosCampos, Dulcinéa Maria Barbosainfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T02:43:08Zoai:repositorio.unb.br:10482/2808Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T02:43:08Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
title Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
spellingShingle Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
Semerene, Amélia Regina
Helminto
Infecção
Inflamação
title_short Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
title_full Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
title_fullStr Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
title_full_unstemmed Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
title_sort Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
author Semerene, Amélia Regina
author_facet Semerene, Amélia Regina
Lino Junior, Ruy de Souza
Oliveira, Jayrson Araújo
Magalhães, Albino Verçosa de
Stefani, Mariane Martins Araújo
Barbosa, Alverne Passos
Campos, Dulcinéa Maria Barbosa
author_role author
author2 Lino Junior, Ruy de Souza
Oliveira, Jayrson Araújo
Magalhães, Albino Verçosa de
Stefani, Mariane Martins Araújo
Barbosa, Alverne Passos
Campos, Dulcinéa Maria Barbosa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Semerene, Amélia Regina
Lino Junior, Ruy de Souza
Oliveira, Jayrson Araújo
Magalhães, Albino Verçosa de
Stefani, Mariane Martins Araújo
Barbosa, Alverne Passos
Campos, Dulcinéa Maria Barbosa
dc.subject.por.fl_str_mv Helminto
Infecção
Inflamação
topic Helminto
Infecção
Inflamação
description The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.
publishDate 2004
dc.date.none.fl_str_mv 2004
2009-12-21T18:56:38Z
2009-12-21T18:56:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009.
http://repositorio.unb.br/handle/10482/2808
http://dx.doi.org/10.1590/S0074-02762004000400009
identifier_str_mv SEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009.
url http://repositorio.unb.br/handle/10482/2808
http://dx.doi.org/10.1590/S0074-02762004000400009
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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