Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/2808 http://dx.doi.org/10.1590/S0074-02762004000400009 |
Resumo: | The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells. |
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Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine modelHelmintoInfecçãoInflamaçãoThe goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.Faculdade de Medicina (FMD)2009-12-21T18:56:38Z2009-12-21T18:56:38Z2004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009.http://repositorio.unb.br/handle/10482/2808http://dx.doi.org/10.1590/S0074-02762004000400009Semerene, Amélia ReginaLino Junior, Ruy de SouzaOliveira, Jayrson AraújoMagalhães, Albino Verçosa deStefani, Mariane Martins AraújoBarbosa, Alverne PassosCampos, Dulcinéa Maria Barbosainfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T02:43:08Zoai:repositorio.unb.br:10482/2808Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T02:43:08Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
title |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
spellingShingle |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model Semerene, Amélia Regina Helminto Infecção Inflamação |
title_short |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
title_full |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
title_fullStr |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
title_full_unstemmed |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
title_sort |
Experimental Lagochilascariosis : histopathological study of inflammatory response to larval migration in the Murine model |
author |
Semerene, Amélia Regina |
author_facet |
Semerene, Amélia Regina Lino Junior, Ruy de Souza Oliveira, Jayrson Araújo Magalhães, Albino Verçosa de Stefani, Mariane Martins Araújo Barbosa, Alverne Passos Campos, Dulcinéa Maria Barbosa |
author_role |
author |
author2 |
Lino Junior, Ruy de Souza Oliveira, Jayrson Araújo Magalhães, Albino Verçosa de Stefani, Mariane Martins Araújo Barbosa, Alverne Passos Campos, Dulcinéa Maria Barbosa |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Semerene, Amélia Regina Lino Junior, Ruy de Souza Oliveira, Jayrson Araújo Magalhães, Albino Verçosa de Stefani, Mariane Martins Araújo Barbosa, Alverne Passos Campos, Dulcinéa Maria Barbosa |
dc.subject.por.fl_str_mv |
Helminto Infecção Inflamação |
topic |
Helminto Infecção Inflamação |
description |
The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs “per os” and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 2009-12-21T18:56:38Z 2009-12-21T18:56:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009. http://repositorio.unb.br/handle/10482/2808 http://dx.doi.org/10.1590/S0074-02762004000400009 |
identifier_str_mv |
SEMERENE, Amélia Regina et al. Experimental lagochilascariosis: histopathological study of inflammatory response to larval migration in the murine model. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 393-398, 2004. Disponível em: <http://www.scielo.br/pdf/mioc/v99n4/v99n4a09.pdf>. Acesso em: 1 dez. 2009. |
url |
http://repositorio.unb.br/handle/10482/2808 http://dx.doi.org/10.1590/S0074-02762004000400009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
repository.name.fl_str_mv |
Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
repositorio@unb.br |
_version_ |
1814508211644923904 |