Prevention and control of Chagas Disease : an overview
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/32382 http://dx.doi.org/10.9734/ISRR/2018/42594 |
Resumo: | Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health. |
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Prevention and control of Chagas Disease : an overviewChagas, Doença deTrypanosoma cruziDoenças sexualmente transmissíveisPrevençãoChagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health.Faculdade de Medicina (FMD)SCIENCEDOMAIN International2018-08-02T12:28:42Z2018-08-02T12:28:42Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfTEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594.http://repositorio.unb.br/handle/10482/32382http://dx.doi.org/10.9734/ISRR/2018/42594© 2018 Teixeira et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/openAccessTeixeira, Antonio Raimundo Lima CruzGomes, C.Rosa, A. C.Araujo, P. F.Anunciação, C. E.Lacerda, E. SilveiraAlmeida, A. B.Petrofeza, S.porreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T19:00:07Zoai:repositorio.unb.br:10482/32382Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T19:00:07Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Prevention and control of Chagas Disease : an overview |
title |
Prevention and control of Chagas Disease : an overview |
spellingShingle |
Prevention and control of Chagas Disease : an overview Teixeira, Antonio Raimundo Lima Cruz Chagas, Doença de Trypanosoma cruzi Doenças sexualmente transmissíveis Prevenção |
title_short |
Prevention and control of Chagas Disease : an overview |
title_full |
Prevention and control of Chagas Disease : an overview |
title_fullStr |
Prevention and control of Chagas Disease : an overview |
title_full_unstemmed |
Prevention and control of Chagas Disease : an overview |
title_sort |
Prevention and control of Chagas Disease : an overview |
author |
Teixeira, Antonio Raimundo Lima Cruz |
author_facet |
Teixeira, Antonio Raimundo Lima Cruz Gomes, C. Rosa, A. C. Araujo, P. F. Anunciação, C. E. Lacerda, E. Silveira Almeida, A. B. Petrofeza, S. |
author_role |
author |
author2 |
Gomes, C. Rosa, A. C. Araujo, P. F. Anunciação, C. E. Lacerda, E. Silveira Almeida, A. B. Petrofeza, S. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Antonio Raimundo Lima Cruz Gomes, C. Rosa, A. C. Araujo, P. F. Anunciação, C. E. Lacerda, E. Silveira Almeida, A. B. Petrofeza, S. |
dc.subject.por.fl_str_mv |
Chagas, Doença de Trypanosoma cruzi Doenças sexualmente transmissíveis Prevenção |
topic |
Chagas, Doença de Trypanosoma cruzi Doenças sexualmente transmissíveis Prevenção |
description |
Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-02T12:28:42Z 2018-08-02T12:28:42Z 2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
TEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594. http://repositorio.unb.br/handle/10482/32382 http://dx.doi.org/10.9734/ISRR/2018/42594 |
identifier_str_mv |
TEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594. |
url |
http://repositorio.unb.br/handle/10482/32382 http://dx.doi.org/10.9734/ISRR/2018/42594 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
SCIENCEDOMAIN International |
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SCIENCEDOMAIN International |
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reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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repositorio@unb.br |
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