Prevention and control of Chagas Disease : an overview

Detalhes bibliográficos
Autor(a) principal: Teixeira, Antonio Raimundo Lima Cruz
Data de Publicação: 2018
Outros Autores: Gomes, C., Rosa, A. C., Araujo, P. F., Anunciação, C. E., Lacerda, E. Silveira, Almeida, A. B., Petrofeza, S.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/32382
http://dx.doi.org/10.9734/ISRR/2018/42594
Resumo: Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health.
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spelling Prevention and control of Chagas Disease : an overviewChagas, Doença deTrypanosoma cruziDoenças sexualmente transmissíveisPrevençãoChagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health.Faculdade de Medicina (FMD)SCIENCEDOMAIN International2018-08-02T12:28:42Z2018-08-02T12:28:42Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfTEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594.http://repositorio.unb.br/handle/10482/32382http://dx.doi.org/10.9734/ISRR/2018/42594© 2018 Teixeira et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/openAccessTeixeira, Antonio Raimundo Lima CruzGomes, C.Rosa, A. C.Araujo, P. F.Anunciação, C. E.Lacerda, E. SilveiraAlmeida, A. B.Petrofeza, S.porreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T19:00:07Zoai:repositorio.unb.br:10482/32382Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T19:00:07Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Prevention and control of Chagas Disease : an overview
title Prevention and control of Chagas Disease : an overview
spellingShingle Prevention and control of Chagas Disease : an overview
Teixeira, Antonio Raimundo Lima Cruz
Chagas, Doença de
Trypanosoma cruzi
Doenças sexualmente transmissíveis
Prevenção
title_short Prevention and control of Chagas Disease : an overview
title_full Prevention and control of Chagas Disease : an overview
title_fullStr Prevention and control of Chagas Disease : an overview
title_full_unstemmed Prevention and control of Chagas Disease : an overview
title_sort Prevention and control of Chagas Disease : an overview
author Teixeira, Antonio Raimundo Lima Cruz
author_facet Teixeira, Antonio Raimundo Lima Cruz
Gomes, C.
Rosa, A. C.
Araujo, P. F.
Anunciação, C. E.
Lacerda, E. Silveira
Almeida, A. B.
Petrofeza, S.
author_role author
author2 Gomes, C.
Rosa, A. C.
Araujo, P. F.
Anunciação, C. E.
Lacerda, E. Silveira
Almeida, A. B.
Petrofeza, S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Antonio Raimundo Lima Cruz
Gomes, C.
Rosa, A. C.
Araujo, P. F.
Anunciação, C. E.
Lacerda, E. Silveira
Almeida, A. B.
Petrofeza, S.
dc.subject.por.fl_str_mv Chagas, Doença de
Trypanosoma cruzi
Doenças sexualmente transmissíveis
Prevenção
topic Chagas, Doença de
Trypanosoma cruzi
Doenças sexualmente transmissíveis
Prevenção
description Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-02T12:28:42Z
2018-08-02T12:28:42Z
2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv TEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594.
http://repositorio.unb.br/handle/10482/32382
http://dx.doi.org/10.9734/ISRR/2018/42594
identifier_str_mv TEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594.
url http://repositorio.unb.br/handle/10482/32382
http://dx.doi.org/10.9734/ISRR/2018/42594
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language por
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dc.publisher.none.fl_str_mv SCIENCEDOMAIN International
publisher.none.fl_str_mv SCIENCEDOMAIN International
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
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reponame_str Repositório Institucional da UnB
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repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
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