High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/25981 https://dx.doi.org/10.1590/S0074-02762003000100019 |
Resumo: | We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A. |
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High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controlsMedicamentos - análiseMetais pesadosLeishmaniose cutâneaChumboArsênioToxidadeEfeitos adversosWe analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.Faculdade de Medicina (FMD)Instituto Oswaldo Cruz, Ministério da Saúde2017-12-07T04:37:35Z2017-12-07T04:37:35Z2003-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020.http://repositorio.unb.br/handle/10482/25981https://dx.doi.org/10.1590/S0074-02762003000100019Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&tlng=en. Acesso em: 04 dez. 2020.info:eu-repo/semantics/openAccessRomero, Gustavo Adolfo SierraFlores, Érico Marlon de MoraesNoronha, Elza FerreiraMacêdo, Vanize de Oliveiraengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-05-24T10:40:13Zoai:repositorio.unb.br:10482/25981Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-05-24T10:40:13Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
title |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
spellingShingle |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls Romero, Gustavo Adolfo Sierra Medicamentos - análise Metais pesados Leishmaniose cutânea Chumbo Arsênio Toxidade Efeitos adversos |
title_short |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
title_full |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
title_fullStr |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
title_full_unstemmed |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
title_sort |
High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
author |
Romero, Gustavo Adolfo Sierra |
author_facet |
Romero, Gustavo Adolfo Sierra Flores, Érico Marlon de Moraes Noronha, Elza Ferreira Macêdo, Vanize de Oliveira |
author_role |
author |
author2 |
Flores, Érico Marlon de Moraes Noronha, Elza Ferreira Macêdo, Vanize de Oliveira |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Romero, Gustavo Adolfo Sierra Flores, Érico Marlon de Moraes Noronha, Elza Ferreira Macêdo, Vanize de Oliveira |
dc.subject.por.fl_str_mv |
Medicamentos - análise Metais pesados Leishmaniose cutânea Chumbo Arsênio Toxidade Efeitos adversos |
topic |
Medicamentos - análise Metais pesados Leishmaniose cutânea Chumbo Arsênio Toxidade Efeitos adversos |
description |
We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-01 2017-12-07T04:37:35Z 2017-12-07T04:37:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020. http://repositorio.unb.br/handle/10482/25981 https://dx.doi.org/10.1590/S0074-02762003000100019 |
identifier_str_mv |
ROMERO, Gustavo Adolfo Sierra et al. High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 1, p. 145-149, jan. 2003. DOI: https://doi.org/10.1590/S0074-02762003000100019. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019&lng=en&nrm=iso. Acesso em: 04 dez. 2020. |
url |
http://repositorio.unb.br/handle/10482/25981 https://dx.doi.org/10.1590/S0074-02762003000100019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
repository.name.fl_str_mv |
Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
repositorio@unb.br |
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1810580826456326144 |