Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/25735 https://dx.doi.org/10.1590/S0100-879X2001000900016 |
Resumo: | Ketamine is believed to reduce airway and pulmonary tissue resistance. The aim of the present study was to determine the effects of ketamine on the resistive, elastic and viscoelastic/inhomogeneous mechanical properties of the respiratory system, lungs and chest wall, and to relate the mechanical data to findings from histological lung analysis in normal animals. Fifteen adult male Wistar rats were assigned randomly to two groups: control (N = 7) and ketamine (N = 8). All animals were sedated (diazepam, 5 mg, ip) and anesthetized with pentobarbital sodium (20 mg/kg, ip) or ketamine (30 mg/kg, ip). The rats were paralyzed and ventilated mechanically. Ketamine increased lung viscoelastic/inhomogeneous pressure (26%) compared to the control group. Dynamic and static elastances were similar in both groups, but the difference was greater in the ketamine than in the control group. Lung morphometry demonstrated dilation of alveolar ducts and increased areas of alveolar collapse in the ketamine group. In conclusion, ketamine did not act at the airway level but acted at the lung periphery increasing mechanical inhomogeneities possibly resulting from dilation of distal airways and alveolar collapse. |
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Alves-Neto, O.Tavares, P.Rocco, P.R.M.Zin, W.A.2017-12-07T04:33:56Z2017-12-07T04:33:56Z2001Braz J Med Biol Res,v.34,n.9,p.1217-1223,2001http://repositorio.unb.br/handle/10482/25735https://dx.doi.org/10.1590/S0100-879X2001000900016Ketamine is believed to reduce airway and pulmonary tissue resistance. The aim of the present study was to determine the effects of ketamine on the resistive, elastic and viscoelastic/inhomogeneous mechanical properties of the respiratory system, lungs and chest wall, and to relate the mechanical data to findings from histological lung analysis in normal animals. Fifteen adult male Wistar rats were assigned randomly to two groups: control (N = 7) and ketamine (N = 8). All animals were sedated (diazepam, 5 mg, ip) and anesthetized with pentobarbital sodium (20 mg/kg, ip) or ketamine (30 mg/kg, ip). The rats were paralyzed and ventilated mechanically. Ketamine increased lung viscoelastic/inhomogeneous pressure (26%) compared to the control group. Dynamic and static elastances were similar in both groups, but the difference was greater in the ketamine than in the control group. Lung morphometry demonstrated dilation of alveolar ducts and increased areas of alveolar collapse in the ketamine group. In conclusion, ketamine did not act at the airway level but acted at the lung periphery increasing mechanical inhomogeneities possibly resulting from dilation of distal airways and alveolar collapse.Em processamentoAssociação Brasileira de Divulgação CientíficaRespiratory mechanics and morphometric changes during anesthesia with ketamine in normal ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleketamineelastancelung tissueresistive pressureviscoelasticityratinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINAL4107.pdfapplication/pdf47468http://repositorio2.unb.br/jspui/bitstream/10482/25735/1/4107.pdf7eeb72273b468de48421bf27591f6e51MD51open access10482/257352023-10-09 18:02:58.406open accessoai:repositorio2.unb.br:10482/25735Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-10-09T21:02:58Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
title |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
spellingShingle |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats Alves-Neto, O. ketamine elastance lung tissue resistive pressure viscoelasticity rat |
title_short |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
title_full |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
title_fullStr |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
title_full_unstemmed |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
title_sort |
Respiratory mechanics and morphometric changes during anesthesia with ketamine in normal rats |
author |
Alves-Neto, O. |
author_facet |
Alves-Neto, O. Tavares, P. Rocco, P.R.M. Zin, W.A. |
author_role |
author |
author2 |
Tavares, P. Rocco, P.R.M. Zin, W.A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves-Neto, O. Tavares, P. Rocco, P.R.M. Zin, W.A. |
dc.subject.keyword.pt_BR.fl_str_mv |
ketamine elastance lung tissue resistive pressure viscoelasticity rat |
topic |
ketamine elastance lung tissue resistive pressure viscoelasticity rat |
description |
Ketamine is believed to reduce airway and pulmonary tissue resistance. The aim of the present study was to determine the effects of ketamine on the resistive, elastic and viscoelastic/inhomogeneous mechanical properties of the respiratory system, lungs and chest wall, and to relate the mechanical data to findings from histological lung analysis in normal animals. Fifteen adult male Wistar rats were assigned randomly to two groups: control (N = 7) and ketamine (N = 8). All animals were sedated (diazepam, 5 mg, ip) and anesthetized with pentobarbital sodium (20 mg/kg, ip) or ketamine (30 mg/kg, ip). The rats were paralyzed and ventilated mechanically. Ketamine increased lung viscoelastic/inhomogeneous pressure (26%) compared to the control group. Dynamic and static elastances were similar in both groups, but the difference was greater in the ketamine than in the control group. Lung morphometry demonstrated dilation of alveolar ducts and increased areas of alveolar collapse in the ketamine group. In conclusion, ketamine did not act at the airway level but acted at the lung periphery increasing mechanical inhomogeneities possibly resulting from dilation of distal airways and alveolar collapse. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:33:56Z |
dc.date.available.fl_str_mv |
2017-12-07T04:33:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Braz J Med Biol Res,v.34,n.9,p.1217-1223,2001 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/25735 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S0100-879X2001000900016 |
identifier_str_mv |
Braz J Med Biol Res,v.34,n.9,p.1217-1223,2001 |
url |
http://repositorio.unb.br/handle/10482/25735 https://dx.doi.org/10.1590/S0100-879X2001000900016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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UNB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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http://repositorio2.unb.br/jspui/bitstream/10482/25735/1/4107.pdf |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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