The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/31826 http://dx.doi.org/10.1155/2014/185617 |
Resumo: | Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side effects, such as nephrotoxicity and ototoxicity. Ototoxicity produced by cisplatin is usually persistent, depending on the age of the patient, the cumulative number of doses, the number of chemotherapy cycles, the history of noise exposure, and deteriorating renal function. The mechanism of the ototoxicity caused by cisplatin is based on the generation of reactive oxygen species, which interfere with the antioxidant protection of the organ of Corti. Thus, protecting the cochlea with antioxidants ameliorates ototoxicity from cisplatin. In this context, melatonin appears as a therapeutic option for preventing the ototoxic effects of cisplatin, since the research in the last decade has proven its ability to be both a direct free radical scavenger and indirect antioxidant. In this sense, some of the evidence suggesting that melatonin is efficient for combating cisplatin-induced ototoxicity is summarized and discussed in this paper. |
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The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approachMelatoninaPrevençãoTratamentoAgentes antineoplásicosOtotoxicidadeCisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side effects, such as nephrotoxicity and ototoxicity. Ototoxicity produced by cisplatin is usually persistent, depending on the age of the patient, the cumulative number of doses, the number of chemotherapy cycles, the history of noise exposure, and deteriorating renal function. The mechanism of the ototoxicity caused by cisplatin is based on the generation of reactive oxygen species, which interfere with the antioxidant protection of the organ of Corti. Thus, protecting the cochlea with antioxidants ameliorates ototoxicity from cisplatin. In this context, melatonin appears as a therapeutic option for preventing the ototoxic effects of cisplatin, since the research in the last decade has proven its ability to be both a direct free radical scavenger and indirect antioxidant. In this sense, some of the evidence suggesting that melatonin is efficient for combating cisplatin-induced ototoxicity is summarized and discussed in this paper.Faculdade de Medicina (FMD)Hindawi2018-05-11T12:49:16Z2018-05-11T12:49:16Z2014-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfARAUJO, Juliana Gusmão de et al. The potential use of melatonin for preventing cisplatin ototoxicity: an insight for a clinical approach. Advances in Otolaryngology, Londres, v. 2014, Article ID 185617, p. 1-8, ago. 2014. Disponível em: <https://www.hindawi.com/archive/2014/185617/>. Acesso em: 7 dez. 2017. doi: http://dx.doi.org/10.1155/2014/185617.http://repositorio.unb.br/handle/10482/31826http://dx.doi.org/10.1155/2014/185617Copyright © 2014 Juliana Gusmão de Araujo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.hindawi.com/archive/2014/185617/. Acesso em: 7 dez. 2017.info:eu-repo/semantics/openAccessAraujo, Juliana Gusmão deSampaio, André Luiz LopesVenosa, Alessandra RamosOliveira, Carlos Augusto Costa Pires deporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T20:10:41Zoai:repositorio.unb.br:10482/31826Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T20:10:41Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
title |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
spellingShingle |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach Araujo, Juliana Gusmão de Melatonina Prevenção Tratamento Agentes antineoplásicos Ototoxicidade |
title_short |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
title_full |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
title_fullStr |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
title_full_unstemmed |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
title_sort |
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach |
author |
Araujo, Juliana Gusmão de |
author_facet |
Araujo, Juliana Gusmão de Sampaio, André Luiz Lopes Venosa, Alessandra Ramos Oliveira, Carlos Augusto Costa Pires de |
author_role |
author |
author2 |
Sampaio, André Luiz Lopes Venosa, Alessandra Ramos Oliveira, Carlos Augusto Costa Pires de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Araujo, Juliana Gusmão de Sampaio, André Luiz Lopes Venosa, Alessandra Ramos Oliveira, Carlos Augusto Costa Pires de |
dc.subject.por.fl_str_mv |
Melatonina Prevenção Tratamento Agentes antineoplásicos Ototoxicidade |
topic |
Melatonina Prevenção Tratamento Agentes antineoplásicos Ototoxicidade |
description |
Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side effects, such as nephrotoxicity and ototoxicity. Ototoxicity produced by cisplatin is usually persistent, depending on the age of the patient, the cumulative number of doses, the number of chemotherapy cycles, the history of noise exposure, and deteriorating renal function. The mechanism of the ototoxicity caused by cisplatin is based on the generation of reactive oxygen species, which interfere with the antioxidant protection of the organ of Corti. Thus, protecting the cochlea with antioxidants ameliorates ototoxicity from cisplatin. In this context, melatonin appears as a therapeutic option for preventing the ototoxic effects of cisplatin, since the research in the last decade has proven its ability to be both a direct free radical scavenger and indirect antioxidant. In this sense, some of the evidence suggesting that melatonin is efficient for combating cisplatin-induced ototoxicity is summarized and discussed in this paper. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 2018-05-11T12:49:16Z 2018-05-11T12:49:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ARAUJO, Juliana Gusmão de et al. The potential use of melatonin for preventing cisplatin ototoxicity: an insight for a clinical approach. Advances in Otolaryngology, Londres, v. 2014, Article ID 185617, p. 1-8, ago. 2014. Disponível em: <https://www.hindawi.com/archive/2014/185617/>. Acesso em: 7 dez. 2017. doi: http://dx.doi.org/10.1155/2014/185617. http://repositorio.unb.br/handle/10482/31826 http://dx.doi.org/10.1155/2014/185617 |
identifier_str_mv |
ARAUJO, Juliana Gusmão de et al. The potential use of melatonin for preventing cisplatin ototoxicity: an insight for a clinical approach. Advances in Otolaryngology, Londres, v. 2014, Article ID 185617, p. 1-8, ago. 2014. Disponível em: <https://www.hindawi.com/archive/2014/185617/>. Acesso em: 7 dez. 2017. doi: http://dx.doi.org/10.1155/2014/185617. |
url |
http://repositorio.unb.br/handle/10482/31826 http://dx.doi.org/10.1155/2014/185617 |
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Hindawi |
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Hindawi |
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Universidade de Brasília (UnB) |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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