Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio2.unb.br/jspui/handle/10482/48763 https://doi.org/10.3390/nano12162760 10.3390/nano12162760 https://orcid.org/0000-0003-3366-106X https://orcid.org/0000-0002-2137-9588 https://orcid.org/0000-0003-1210-8329 |
Resumo: | This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological). |
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Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermiaMagnetohipertermiaNanopartículas magnéticasFluidos magnéticosTemperaturaThis study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).Instituto de Ciências Biológicas (IB)Departamento de Genética e Morfologia (IB GEM)Faculdade UnB Ceilândia (FCE)Instituto de Física (IF)Programa de Pós-Graduação em Ciências e Tecnologias em SaúdeMDPIUniversity of Brasília, Institute of Biological Sciences, Department of Genetics & MorphologyUniversity of Brasília, Faculty of Ceilândia, Green Nanotechnology GroupUniversity of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health TechnologiesFederal University of Goiás, Institute of PhysicsUniversity of Brasília, Institute of PhysicsFederal Institute of BrasíliaFederal University of Goiás, Institute of PhysicsFederal University of Goiás, CNanoMedUniversity of Brasília, Institute of Biological Sciences, Department of Genetics & MorphologyUniversity of Brasília, Faculty of Ceilândia, Green Nanotechnology GroupUniversity of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health TechnologiesUniversity of Brasília, Institute of PhysicsCatholic University of BrasíliaSiqueira, Elis Regina LimaPinheiro, Willie OliveiraAquino, Victor Raul RomeroCoelho, Breno Cunha PintoBakuzis, Andris FigueiroaAzevedo, Ricardo BentesSousa, Marcelo HenriqueMorais, Paulo Cesar2024-07-11T16:32:24Z2024-07-11T16:32:24Z2022-08-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760http://repositorio2.unb.br/jspui/handle/10482/48763https://doi.org/10.3390/nano12162760 10.3390/nano12162760https://orcid.org/0000-0003-3366-106Xhttps://orcid.org/0000-0002-2137-9588https://orcid.org/0000-0003-1210-8329eng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-07-11T16:41:03Zoai:repositorio.unb.br:10482/48763Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-07-11T16:41:03Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
title |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
spellingShingle |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia Siqueira, Elis Regina Lima Magnetohipertermia Nanopartículas magnéticas Fluidos magnéticos Temperatura |
title_short |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
title_full |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
title_fullStr |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
title_full_unstemmed |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
title_sort |
Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia |
author |
Siqueira, Elis Regina Lima |
author_facet |
Siqueira, Elis Regina Lima Pinheiro, Willie Oliveira Aquino, Victor Raul Romero Coelho, Breno Cunha Pinto Bakuzis, Andris Figueiroa Azevedo, Ricardo Bentes Sousa, Marcelo Henrique Morais, Paulo Cesar |
author_role |
author |
author2 |
Pinheiro, Willie Oliveira Aquino, Victor Raul Romero Coelho, Breno Cunha Pinto Bakuzis, Andris Figueiroa Azevedo, Ricardo Bentes Sousa, Marcelo Henrique Morais, Paulo Cesar |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies Federal University of Goiás, Institute of Physics University of Brasília, Institute of Physics Federal Institute of Brasília Federal University of Goiás, Institute of Physics Federal University of Goiás, CNanoMed University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies University of Brasília, Institute of Physics Catholic University of Brasília |
dc.contributor.author.fl_str_mv |
Siqueira, Elis Regina Lima Pinheiro, Willie Oliveira Aquino, Victor Raul Romero Coelho, Breno Cunha Pinto Bakuzis, Andris Figueiroa Azevedo, Ricardo Bentes Sousa, Marcelo Henrique Morais, Paulo Cesar |
dc.subject.por.fl_str_mv |
Magnetohipertermia Nanopartículas magnéticas Fluidos magnéticos Temperatura |
topic |
Magnetohipertermia Nanopartículas magnéticas Fluidos magnéticos Temperatura |
description |
This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-12 2024-07-11T16:32:24Z 2024-07-11T16:32:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760 http://repositorio2.unb.br/jspui/handle/10482/48763 https://doi.org/10.3390/nano12162760 10.3390/nano12162760 https://orcid.org/0000-0003-3366-106X https://orcid.org/0000-0002-2137-9588 https://orcid.org/0000-0003-1210-8329 |
identifier_str_mv |
SIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760 |
url |
http://repositorio2.unb.br/jspui/handle/10482/48763 https://doi.org/10.3390/nano12162760 10.3390/nano12162760 https://orcid.org/0000-0003-3366-106X https://orcid.org/0000-0002-2137-9588 https://orcid.org/0000-0003-1210-8329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
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UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
repositorio@unb.br |
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1814508194454568960 |