Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia

Detalhes bibliográficos
Autor(a) principal: Siqueira, Elis Regina Lima
Data de Publicação: 2022
Outros Autores: Pinheiro, Willie Oliveira, Aquino, Victor Raul Romero, Coelho, Breno Cunha Pinto, Bakuzis, Andris Figueiroa, Azevedo, Ricardo Bentes, Sousa, Marcelo Henrique, Morais, Paulo Cesar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio2.unb.br/jspui/handle/10482/48763
https://doi.org/10.3390/nano12162760 10.3390/nano12162760
https://orcid.org/0000-0003-3366-106X
https://orcid.org/0000-0002-2137-9588
https://orcid.org/0000-0003-1210-8329
Resumo: This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).
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spelling Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermiaMagnetohipertermiaNanopartículas magnéticasFluidos magnéticosTemperaturaThis study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).Instituto de Ciências Biológicas (IB)Departamento de Genética e Morfologia (IB GEM)Faculdade UnB Ceilândia (FCE)Instituto de Física (IF)Programa de Pós-Graduação em Ciências e Tecnologias em SaúdeMDPIUniversity of Brasília, Institute of Biological Sciences, Department of Genetics & MorphologyUniversity of Brasília, Faculty of Ceilândia, Green Nanotechnology GroupUniversity of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health TechnologiesFederal University of Goiás, Institute of PhysicsUniversity of Brasília, Institute of PhysicsFederal Institute of BrasíliaFederal University of Goiás, Institute of PhysicsFederal University of Goiás, CNanoMedUniversity of Brasília, Institute of Biological Sciences, Department of Genetics & MorphologyUniversity of Brasília, Faculty of Ceilândia, Green Nanotechnology GroupUniversity of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health TechnologiesUniversity of Brasília, Institute of PhysicsCatholic University of BrasíliaSiqueira, Elis Regina LimaPinheiro, Willie OliveiraAquino, Victor Raul RomeroCoelho, Breno Cunha PintoBakuzis, Andris FigueiroaAzevedo, Ricardo BentesSousa, Marcelo HenriqueMorais, Paulo Cesar2024-07-11T16:32:24Z2024-07-11T16:32:24Z2022-08-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760http://repositorio2.unb.br/jspui/handle/10482/48763https://doi.org/10.3390/nano12162760 10.3390/nano12162760https://orcid.org/0000-0003-3366-106Xhttps://orcid.org/0000-0002-2137-9588https://orcid.org/0000-0003-1210-8329eng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-07-11T16:41:03Zoai:repositorio.unb.br:10482/48763Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-07-11T16:41:03Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
title Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
spellingShingle Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
Siqueira, Elis Regina Lima
Magnetohipertermia
Nanopartículas magnéticas
Fluidos magnéticos
Temperatura
title_short Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
title_full Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
title_fullStr Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
title_full_unstemmed Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
title_sort Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia
author Siqueira, Elis Regina Lima
author_facet Siqueira, Elis Regina Lima
Pinheiro, Willie Oliveira
Aquino, Victor Raul Romero
Coelho, Breno Cunha Pinto
Bakuzis, Andris Figueiroa
Azevedo, Ricardo Bentes
Sousa, Marcelo Henrique
Morais, Paulo Cesar
author_role author
author2 Pinheiro, Willie Oliveira
Aquino, Victor Raul Romero
Coelho, Breno Cunha Pinto
Bakuzis, Andris Figueiroa
Azevedo, Ricardo Bentes
Sousa, Marcelo Henrique
Morais, Paulo Cesar
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology
University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group
University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies
Federal University of Goiás, Institute of Physics
University of Brasília, Institute of Physics
Federal Institute of Brasília
Federal University of Goiás, Institute of Physics
Federal University of Goiás, CNanoMed
University of Brasília, Institute of Biological Sciences, Department of Genetics & Morphology
University of Brasília, Faculty of Ceilândia, Green Nanotechnology Group
University of Brasília, Faculty of Ceilândia, Post-Graduation Program in Sciences and Health Technologies
University of Brasília, Institute of Physics
Catholic University of Brasília
dc.contributor.author.fl_str_mv Siqueira, Elis Regina Lima
Pinheiro, Willie Oliveira
Aquino, Victor Raul Romero
Coelho, Breno Cunha Pinto
Bakuzis, Andris Figueiroa
Azevedo, Ricardo Bentes
Sousa, Marcelo Henrique
Morais, Paulo Cesar
dc.subject.por.fl_str_mv Magnetohipertermia
Nanopartículas magnéticas
Fluidos magnéticos
Temperatura
topic Magnetohipertermia
Nanopartículas magnéticas
Fluidos magnéticos
Temperatura
description This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 ◦C (naked maghemite), 44–58 ◦C (g/m = 0.0376) and 33–51 ◦C (g/m = 0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-12
2024-07-11T16:32:24Z
2024-07-11T16:32:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760
http://repositorio2.unb.br/jspui/handle/10482/48763
https://doi.org/10.3390/nano12162760 10.3390/nano12162760
https://orcid.org/0000-0003-3366-106X
https://orcid.org/0000-0002-2137-9588
https://orcid.org/0000-0003-1210-8329
identifier_str_mv SIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, [S. l.], v. 12, n. 16, 2760, DOI: https://doi.org/10.3390/nano12162760 10.3390/nano12162760. Disponível em: https://www.mdpi.com/2079-4991/12/16/2760
url http://repositorio2.unb.br/jspui/handle/10482/48763
https://doi.org/10.3390/nano12162760 10.3390/nano12162760
https://orcid.org/0000-0003-3366-106X
https://orcid.org/0000-0002-2137-9588
https://orcid.org/0000-0003-1210-8329
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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