Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice

• Autor(a) principal: Santarem, Ana Angélica Amorim
• Data de Publicação: 2014
• Outros Autores: Greggianin, Gabriel Frizon, Debastiani, Rafaela Garcia, Ribeiro, Jefferson Bruno Pereira, Polli, Démerson André, Sampaio, Raimunda Nonata Ribeiro
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/29126; https://dx.doi.org/10.1590/0037-8682-0202-2013
• topic: Leishmaniose cutânea; Pentoxifilina; Miltefosina

Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.