Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio2.unb.br/jspui/handle/10482/47509 https://doi.org/10.3389/fpubh.2023.1236384 |
Resumo: | Free-ranging non-human primates (NHP) can live in anthropized areas or urban environments in close contact with human populations. This condition can enable the emergence and transmission of high-impact zoonotic pathogens. For the first time, we detected a coinfection of the yellow fever (YF) virus with Toxoplasma gondii in a free-ranging NHP in a highly urbanized area of a metropolis in Brazil. Specifically, we observed this coinfection in a black-tufted marmoset found dead and taken for a necropsy by the local health surveillance service. After conducting an epidemiological investigation, characterizing the pathological features, and performing molecular assays, we confirmed that the marmoset developed an acute fatal infection caused by T. gondii in coinfection with a new YF virus South American-1 sub-lineage. As a result, we have raised concerns about the public health implications of these findings and discussed the importance of diagnosis and surveillance of zoonotic agents in urbanized NHPs. As competent hosts of zoonotic diseases such as YF and environmental sentinels for toxoplasmosis, NHPs play a crucial role in the One Health framework to predict and prevent the emergence of dangerous human pathogens. |
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Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virusPrimata não humanoToxoplasma gondiiDoenças infecciosasVigilância sanitáriaZoonosesFree-ranging non-human primates (NHP) can live in anthropized areas or urban environments in close contact with human populations. This condition can enable the emergence and transmission of high-impact zoonotic pathogens. For the first time, we detected a coinfection of the yellow fever (YF) virus with Toxoplasma gondii in a free-ranging NHP in a highly urbanized area of a metropolis in Brazil. Specifically, we observed this coinfection in a black-tufted marmoset found dead and taken for a necropsy by the local health surveillance service. After conducting an epidemiological investigation, characterizing the pathological features, and performing molecular assays, we confirmed that the marmoset developed an acute fatal infection caused by T. gondii in coinfection with a new YF virus South American-1 sub-lineage. As a result, we have raised concerns about the public health implications of these findings and discussed the importance of diagnosis and surveillance of zoonotic agents in urbanized NHPs. As competent hosts of zoonotic diseases such as YF and environmental sentinels for toxoplasmosis, NHPs play a crucial role in the One Health framework to predict and prevent the emergence of dangerous human pathogens.Faculdade de Agronomia e Medicina Veterinária (FAV)Programa de Pós-Graduação em Ciências AnimaisFrontiersUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Veterinary Pathology LaboratoryUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Veterinary Pathology LaboratoryUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Veterinary Pathology LaboratoryBrazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable DiseasesBrazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable DiseasesBrazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable DiseasesUniversity of Brasília, Graduate Program in Animal ScienceEnvironmental Health Surveillance Directorate of the Federal DistrictOrganização Pan-Americana da Saúde/ Organização Mundial da Saúde, Brasília, BrazilInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, BrazilInstituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, BrazilInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, BrazilSciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico of Rome, Rome, ItalyInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, BrazilInstituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, BrazilInstituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, BrazilUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Graduate Program in Animal ScienceUniversity of Brasília, Veterinary Pathology LaboratorySousa, Davi Emanuel Ribeiro deWilson, Tais MeziaraMacêdo, Isabel Luana deRomano, Alessandro Pecego MartinsRamos, Daniel G.Passos, Pedro Henrique de OliveiraCosta, Gabriela R. T.Fonseca, Vagnerde SouzaMares-Guia, Maria Angélica M. M.Giovantetti, MartaAlcantara, Luiz Carlos JuniorFilippis, Ana Maria B. dePaludo, Giane ReginaMelo, Cristiano Barros deCastro, Márcio Botelho de2024-01-25T11:34:09Z2024-01-25T11:34:09Z2023-08-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOUSA, Davi E. R. et al. Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus. Frontiers Public Health, v. 11, 21 ago. 2023. DOI: https://doi.org/10.3389/fpubh.2023.1236384. Disponível em: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1236384/full. Acesso em: 23 jan. 2024.http://repositorio2.unb.br/jspui/handle/10482/47509https://doi.org/10.3389/fpubh.2023.1236384engCOPYRIGHT © 2023 Sousa, Wilson, Macêdo, Romano, Ramos, Passos, Costa, Fonseca, Mares-Guia, Giovanetti, Alcantara, de Filippis, Paludo, Melo and Castro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-01-25T11:34:09Zoai:repositorio.unb.br:10482/47509Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-01-25T11:34:09Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
title |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
spellingShingle |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus Sousa, Davi Emanuel Ribeiro de Primata não humano Toxoplasma gondii Doenças infecciosas Vigilância sanitária Zoonoses |
title_short |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
title_full |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
title_fullStr |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
title_full_unstemmed |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
title_sort |
Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus |
author |
Sousa, Davi Emanuel Ribeiro de |
author_facet |
Sousa, Davi Emanuel Ribeiro de Wilson, Tais Meziara Macêdo, Isabel Luana de Romano, Alessandro Pecego Martins Ramos, Daniel G. Passos, Pedro Henrique de Oliveira Costa, Gabriela R. T. Fonseca, Vagnerde Souza Mares-Guia, Maria Angélica M. M. Giovantetti, Marta Alcantara, Luiz Carlos Junior Filippis, Ana Maria B. de Paludo, Giane Regina Melo, Cristiano Barros de Castro, Márcio Botelho de |
author_role |
author |
author2 |
Wilson, Tais Meziara Macêdo, Isabel Luana de Romano, Alessandro Pecego Martins Ramos, Daniel G. Passos, Pedro Henrique de Oliveira Costa, Gabriela R. T. Fonseca, Vagnerde Souza Mares-Guia, Maria Angélica M. M. Giovantetti, Marta Alcantara, Luiz Carlos Junior Filippis, Ana Maria B. de Paludo, Giane Regina Melo, Cristiano Barros de Castro, Márcio Botelho de |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases Brazilian Ministry of Health, Technical Group of Arbovirus Surveillance, Secretariat of Health Surveillance, Department of Communicable Disease Surveillance, General Coordination of Communicable Diseases University of Brasília, Graduate Program in Animal Science Environmental Health Surveillance Directorate of the Federal District Organização Pan-Americana da Saúde/ Organização Mundial da Saúde, Brasília, Brazil Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico of Rome, Rome, Italy Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil Instituto Osawldo Cruz, Fiocruz, Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Rio de Janeiro, Brazil University of Brasília, Graduate Program in Animal Science University of Brasília, Graduate Program in Animal Science University of Brasília, Graduate Program in Animal Science University of Brasília, Veterinary Pathology Laboratory |
dc.contributor.author.fl_str_mv |
Sousa, Davi Emanuel Ribeiro de Wilson, Tais Meziara Macêdo, Isabel Luana de Romano, Alessandro Pecego Martins Ramos, Daniel G. Passos, Pedro Henrique de Oliveira Costa, Gabriela R. T. Fonseca, Vagnerde Souza Mares-Guia, Maria Angélica M. M. Giovantetti, Marta Alcantara, Luiz Carlos Junior Filippis, Ana Maria B. de Paludo, Giane Regina Melo, Cristiano Barros de Castro, Márcio Botelho de |
dc.subject.por.fl_str_mv |
Primata não humano Toxoplasma gondii Doenças infecciosas Vigilância sanitária Zoonoses |
topic |
Primata não humano Toxoplasma gondii Doenças infecciosas Vigilância sanitária Zoonoses |
description |
Free-ranging non-human primates (NHP) can live in anthropized areas or urban environments in close contact with human populations. This condition can enable the emergence and transmission of high-impact zoonotic pathogens. For the first time, we detected a coinfection of the yellow fever (YF) virus with Toxoplasma gondii in a free-ranging NHP in a highly urbanized area of a metropolis in Brazil. Specifically, we observed this coinfection in a black-tufted marmoset found dead and taken for a necropsy by the local health surveillance service. After conducting an epidemiological investigation, characterizing the pathological features, and performing molecular assays, we confirmed that the marmoset developed an acute fatal infection caused by T. gondii in coinfection with a new YF virus South American-1 sub-lineage. As a result, we have raised concerns about the public health implications of these findings and discussed the importance of diagnosis and surveillance of zoonotic agents in urbanized NHPs. As competent hosts of zoonotic diseases such as YF and environmental sentinels for toxoplasmosis, NHPs play a crucial role in the One Health framework to predict and prevent the emergence of dangerous human pathogens. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-21 2024-01-25T11:34:09Z 2024-01-25T11:34:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SOUSA, Davi E. R. et al. Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus. Frontiers Public Health, v. 11, 21 ago. 2023. DOI: https://doi.org/10.3389/fpubh.2023.1236384. Disponível em: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1236384/full. Acesso em: 23 jan. 2024. http://repositorio2.unb.br/jspui/handle/10482/47509 https://doi.org/10.3389/fpubh.2023.1236384 |
identifier_str_mv |
SOUSA, Davi E. R. et al. Case report : urbanized non-human primates as sentinels for human zoonotic diseases : a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus. Frontiers Public Health, v. 11, 21 ago. 2023. DOI: https://doi.org/10.3389/fpubh.2023.1236384. Disponível em: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1236384/full. Acesso em: 23 jan. 2024. |
url |
http://repositorio2.unb.br/jspui/handle/10482/47509 https://doi.org/10.3389/fpubh.2023.1236384 |
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eng |
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openAccess |
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Frontiers |
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Frontiers |
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