The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study

• Autor(a) principal: Santana, Yago Ranniere Teixeira
• Data de Publicação: 2023
• Outros Autores: Andrade, Débora Dornelas Belchior Costa, Barroso, Daniel Holanda, Silva, Andressa Vieira, Oliveira, Lucas Felipe Carvalho, Timbó, Renata Velôzo, Araújo, David Dias, Andrade, Rafael Rocha de, Pellegrini, Marcos Antonio, Carvalho, Fabíola Christian Almeida de, Martins, Luciana Pereira Freire, Gomes, Ciro Martins
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio2.unb.br/jspui/handle/10482/48901; https://doi.org/10.3390/tropicalmed8110489; https://orcid.org/0000-0003-3434-2669; https://orcid.org/0000-0003-1989-7412; https://orcid.org/0000-0001-8594-0015; https://orcid.org/0000-0002-9532-4854; https://orcid.org/0000-0002-3069-6884
• topic: Tungíase; Indígenas; Doenças infecciosas

Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA®) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA® together with animal and environmental interventions are effective measures for the control of tungiasis.