G6PD deficiency in Latin America : systematic review on prevalence and variants

Detalhes bibliográficos
Autor(a) principal: Monteiro, Wuelton Marcelo
Data de Publicação: 2014
Outros Autores: Val, Fernando Fonseca de Almeida, Siqueira, André Machado, Franca, Gabriel Peixoto, Sampaio, Vanderson de Souza, Melo, Gisely Cardoso de, Almeida, Anne Cristine Gomes de, Brito, Marcelo, Peixoto, Henry Maia, Fuller, Douglas, Bassat, Quique, Romero, Gustavo Adolfo Sierra, Oliveira, Maria Regina Fernandes de, Lacerda, Marcus Vinícius Guimarães de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/29137
https://dx.doi.org/10.1590/0074-0276140123
Resumo: Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.
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spelling G6PD deficiency in Latin America : systematic review on prevalence and variantsGlicosefosfato desidrogenaseMaláriaPlasmodium vivaxMedicamentosHemóliseIndígenasPlasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.Faculdade de Medicina (FMD)Instituto Oswaldo Cruz, Ministério da Saúde2017-12-07T05:07:03Z2017-12-07T05:07:03Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020.http://repositorio.unb.br/handle/10482/29137https://dx.doi.org/10.1590/0074-0276140123Memórias do Instituto Oswaldo Cruz - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tln g=en. Acesso em: 21 jul. 2020.info:eu-repo/semantics/openAccessMonteiro, Wuelton MarceloVal, Fernando Fonseca de AlmeidaSiqueira, André MachadoFranca, Gabriel PeixotoSampaio, Vanderson de SouzaMelo, Gisely Cardoso deAlmeida, Anne Cristine Gomes deBrito, MarceloPeixoto, Henry MaiaFuller, DouglasBassat, QuiqueRomero, Gustavo Adolfo SierraOliveira, Maria Regina Fernandes deLacerda, Marcus Vinícius Guimarães deengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-10-17T19:53:15Zoai:repositorio.unb.br:10482/29137Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-10-17T19:53:15Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv G6PD deficiency in Latin America : systematic review on prevalence and variants
title G6PD deficiency in Latin America : systematic review on prevalence and variants
spellingShingle G6PD deficiency in Latin America : systematic review on prevalence and variants
Monteiro, Wuelton Marcelo
Glicosefosfato desidrogenase
Malária
Plasmodium vivax
Medicamentos
Hemólise
Indígenas
title_short G6PD deficiency in Latin America : systematic review on prevalence and variants
title_full G6PD deficiency in Latin America : systematic review on prevalence and variants
title_fullStr G6PD deficiency in Latin America : systematic review on prevalence and variants
title_full_unstemmed G6PD deficiency in Latin America : systematic review on prevalence and variants
title_sort G6PD deficiency in Latin America : systematic review on prevalence and variants
author Monteiro, Wuelton Marcelo
author_facet Monteiro, Wuelton Marcelo
Val, Fernando Fonseca de Almeida
Siqueira, André Machado
Franca, Gabriel Peixoto
Sampaio, Vanderson de Souza
Melo, Gisely Cardoso de
Almeida, Anne Cristine Gomes de
Brito, Marcelo
Peixoto, Henry Maia
Fuller, Douglas
Bassat, Quique
Romero, Gustavo Adolfo Sierra
Oliveira, Maria Regina Fernandes de
Lacerda, Marcus Vinícius Guimarães de
author_role author
author2 Val, Fernando Fonseca de Almeida
Siqueira, André Machado
Franca, Gabriel Peixoto
Sampaio, Vanderson de Souza
Melo, Gisely Cardoso de
Almeida, Anne Cristine Gomes de
Brito, Marcelo
Peixoto, Henry Maia
Fuller, Douglas
Bassat, Quique
Romero, Gustavo Adolfo Sierra
Oliveira, Maria Regina Fernandes de
Lacerda, Marcus Vinícius Guimarães de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Wuelton Marcelo
Val, Fernando Fonseca de Almeida
Siqueira, André Machado
Franca, Gabriel Peixoto
Sampaio, Vanderson de Souza
Melo, Gisely Cardoso de
Almeida, Anne Cristine Gomes de
Brito, Marcelo
Peixoto, Henry Maia
Fuller, Douglas
Bassat, Quique
Romero, Gustavo Adolfo Sierra
Oliveira, Maria Regina Fernandes de
Lacerda, Marcus Vinícius Guimarães de
dc.subject.por.fl_str_mv Glicosefosfato desidrogenase
Malária
Plasmodium vivax
Medicamentos
Hemólise
Indígenas
topic Glicosefosfato desidrogenase
Malária
Plasmodium vivax
Medicamentos
Hemólise
Indígenas
description Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.
publishDate 2014
dc.date.none.fl_str_mv 2014
2017-12-07T05:07:03Z
2017-12-07T05:07:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv MONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020.
http://repositorio.unb.br/handle/10482/29137
https://dx.doi.org/10.1590/0074-0276140123
identifier_str_mv MONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020.
url http://repositorio.unb.br/handle/10482/29137
https://dx.doi.org/10.1590/0074-0276140123
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
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institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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