G6PD deficiency in Latin America : systematic review on prevalence and variants
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/29137 https://dx.doi.org/10.1590/0074-0276140123 |
Resumo: | Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available. |
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G6PD deficiency in Latin America : systematic review on prevalence and variantsGlicosefosfato desidrogenaseMaláriaPlasmodium vivaxMedicamentosHemóliseIndígenasPlasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.Faculdade de Medicina (FMD)Instituto Oswaldo Cruz, Ministério da Saúde2017-12-07T05:07:03Z2017-12-07T05:07:03Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020.http://repositorio.unb.br/handle/10482/29137https://dx.doi.org/10.1590/0074-0276140123Memórias do Instituto Oswaldo Cruz - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tln g=en. Acesso em: 21 jul. 2020.info:eu-repo/semantics/openAccessMonteiro, Wuelton MarceloVal, Fernando Fonseca de AlmeidaSiqueira, André MachadoFranca, Gabriel PeixotoSampaio, Vanderson de SouzaMelo, Gisely Cardoso deAlmeida, Anne Cristine Gomes deBrito, MarceloPeixoto, Henry MaiaFuller, DouglasBassat, QuiqueRomero, Gustavo Adolfo SierraOliveira, Maria Regina Fernandes deLacerda, Marcus Vinícius Guimarães deengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-10-17T19:53:15Zoai:repositorio.unb.br:10482/29137Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-10-17T19:53:15Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
title |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
spellingShingle |
G6PD deficiency in Latin America : systematic review on prevalence and variants Monteiro, Wuelton Marcelo Glicosefosfato desidrogenase Malária Plasmodium vivax Medicamentos Hemólise Indígenas |
title_short |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
title_full |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
title_fullStr |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
title_full_unstemmed |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
title_sort |
G6PD deficiency in Latin America : systematic review on prevalence and variants |
author |
Monteiro, Wuelton Marcelo |
author_facet |
Monteiro, Wuelton Marcelo Val, Fernando Fonseca de Almeida Siqueira, André Machado Franca, Gabriel Peixoto Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Almeida, Anne Cristine Gomes de Brito, Marcelo Peixoto, Henry Maia Fuller, Douglas Bassat, Quique Romero, Gustavo Adolfo Sierra Oliveira, Maria Regina Fernandes de Lacerda, Marcus Vinícius Guimarães de |
author_role |
author |
author2 |
Val, Fernando Fonseca de Almeida Siqueira, André Machado Franca, Gabriel Peixoto Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Almeida, Anne Cristine Gomes de Brito, Marcelo Peixoto, Henry Maia Fuller, Douglas Bassat, Quique Romero, Gustavo Adolfo Sierra Oliveira, Maria Regina Fernandes de Lacerda, Marcus Vinícius Guimarães de |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Monteiro, Wuelton Marcelo Val, Fernando Fonseca de Almeida Siqueira, André Machado Franca, Gabriel Peixoto Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Almeida, Anne Cristine Gomes de Brito, Marcelo Peixoto, Henry Maia Fuller, Douglas Bassat, Quique Romero, Gustavo Adolfo Sierra Oliveira, Maria Regina Fernandes de Lacerda, Marcus Vinícius Guimarães de |
dc.subject.por.fl_str_mv |
Glicosefosfato desidrogenase Malária Plasmodium vivax Medicamentos Hemólise Indígenas |
topic |
Glicosefosfato desidrogenase Malária Plasmodium vivax Medicamentos Hemólise Indígenas |
description |
Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2017-12-07T05:07:03Z 2017-12-07T05:07:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020. http://repositorio.unb.br/handle/10482/29137 https://dx.doi.org/10.1590/0074-0276140123 |
identifier_str_mv |
MONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020. |
url |
http://repositorio.unb.br/handle/10482/29137 https://dx.doi.org/10.1590/0074-0276140123 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
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reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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repositorio@unb.br |
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