Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies

Detalhes bibliográficos
Autor(a) principal: Cruz, Helena Medina
Data de Publicação: 2017
Outros Autores: Scalioni, Leticia de Paula, Paula, Vanessa Salete de, Miguel, Juliana Custódio, Ó, Kycia Maria Rodrigues do, Milagres, Flavio Augusto Pádua, Cruz, Marcelo Santos, Bastos, Francisco Inácio, Flores, Priscila Pollo, Leal, Erotildes, Motta-Castro, Ana Rita Coimbra, Lewis-Ximenez, Lia Laura, Lampe, Elisabeth, Villar, Livia Melo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/30582
http://dx.doi.org/10.1590/0074-02760160394
Resumo: Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.
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spelling Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studiesHepatite BAnticorposRapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.Faculdade de Medicina (FMD)Instituto Oswaldo Cruz, Ministério da Saúde2018-01-04T19:13:15Z2018-01-04T19:13:15Z2017-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCRUZ, Helena Medina et al. Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 209-213, mar. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso>. Acesso em: 22 fev. 2018. Epub Jan 30, 2017. doi: http://dx.doi.org/10.1590/0074-02760160394.http://repositorio.unb.br/handle/10482/30582http://dx.doi.org/10.1590/0074-02760160394Memórias do Instituto Oswaldo Cruz - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso. Acesso em: 22 fev. 2018.info:eu-repo/semantics/openAccessCruz, Helena MedinaScalioni, Leticia de PaulaPaula, Vanessa Salete deMiguel, Juliana CustódioÓ, Kycia Maria Rodrigues doMilagres, Flavio Augusto PáduaCruz, Marcelo SantosBastos, Francisco InácioFlores, Priscila PolloLeal, ErotildesMotta-Castro, Ana Rita CoimbraLewis-Ximenez, Lia LauraLampe, ElisabethVillar, Livia Meloengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T18:42:27Zoai:repositorio.unb.br:10482/30582Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T18:42:27Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
title Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
spellingShingle Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
Cruz, Helena Medina
Hepatite B
Anticorpos
title_short Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
title_full Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
title_fullStr Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
title_full_unstemmed Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
title_sort Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
author Cruz, Helena Medina
author_facet Cruz, Helena Medina
Scalioni, Leticia de Paula
Paula, Vanessa Salete de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Milagres, Flavio Augusto Pádua
Cruz, Marcelo Santos
Bastos, Francisco Inácio
Flores, Priscila Pollo
Leal, Erotildes
Motta-Castro, Ana Rita Coimbra
Lewis-Ximenez, Lia Laura
Lampe, Elisabeth
Villar, Livia Melo
author_role author
author2 Scalioni, Leticia de Paula
Paula, Vanessa Salete de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Milagres, Flavio Augusto Pádua
Cruz, Marcelo Santos
Bastos, Francisco Inácio
Flores, Priscila Pollo
Leal, Erotildes
Motta-Castro, Ana Rita Coimbra
Lewis-Ximenez, Lia Laura
Lampe, Elisabeth
Villar, Livia Melo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Helena Medina
Scalioni, Leticia de Paula
Paula, Vanessa Salete de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Milagres, Flavio Augusto Pádua
Cruz, Marcelo Santos
Bastos, Francisco Inácio
Flores, Priscila Pollo
Leal, Erotildes
Motta-Castro, Ana Rita Coimbra
Lewis-Ximenez, Lia Laura
Lampe, Elisabeth
Villar, Livia Melo
dc.subject.por.fl_str_mv Hepatite B
Anticorpos
topic Hepatite B
Anticorpos
description Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
2018-01-04T19:13:15Z
2018-01-04T19:13:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CRUZ, Helena Medina et al. Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 209-213, mar. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso>. Acesso em: 22 fev. 2018. Epub Jan 30, 2017. doi: http://dx.doi.org/10.1590/0074-02760160394.
http://repositorio.unb.br/handle/10482/30582
http://dx.doi.org/10.1590/0074-02760160394
identifier_str_mv CRUZ, Helena Medina et al. Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 209-213, mar. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000300209&lng=en&nrm=iso>. Acesso em: 22 fev. 2018. Epub Jan 30, 2017. doi: http://dx.doi.org/10.1590/0074-02760160394.
url http://repositorio.unb.br/handle/10482/30582
http://dx.doi.org/10.1590/0074-02760160394
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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