Thrombocytopenia in malaria : who cares?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/27974 https://dx.doi.org/10.1590/S0074-02762011000900007 |
Resumo: | Despite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria. In a systematic review of the literature, platelet counts under 150,000/mm³ ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. Minor bleeding is mentioned in case reports of patients with P. vivax infection and may be explained by medullary compensation with the release of mega platelets in the peripheral circulation by megakaryocytes, thus maintaining a good primary haemostasis. The speculated mechanisms leading to thrombocytopenia are: coagulation disturbances, splenomegaly, bone marrow alterations, antibody-mediated platelet destruction, oxidative stress and the role of platelets as cofactors in triggering severe malaria. Data from experimental models are presented and, despite not being rare, there is no clear recommendation on the adequate management of this haematological complication. In most cases, a conservative approach is adopted and platelet counts usually revert to normal ranges a few days after efficacious antimalarial treatment. More studies are needed to specifically clarify if thrombocytopenia is the cause or consequence of the clinical disease spectrum. |
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Lacerda, Marcus Vinícius Guimarães deMourão, Maria Paula GomesCoelho, Helena Cristina CardosoSantos, João Barberino2017-12-07T04:56:11Z2017-12-07T04:56:11Z2011-08LACERDA, Marcus Vinícius Guimarães et al. Thrombocytopenia in malaria: who cares?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, supl. 1, p. 52-63, ago. 2011. DOI: https://doi.org/10.1590/S0074-02762011000900007. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900007&lng=en&nrm=iso. Acesso: 19 mar. 2021.http://repositorio.unb.br/handle/10482/27974https://dx.doi.org/10.1590/S0074-02762011000900007Instituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Acesso em: 19 mar. 2021.info:eu-repo/semantics/openAccessThrombocytopenia in malaria : who cares?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium falciparumPlasmodium vivaxMaláriaPlaquetasDespite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria. In a systematic review of the literature, platelet counts under 150,000/mm³ ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. Minor bleeding is mentioned in case reports of patients with P. vivax infection and may be explained by medullary compensation with the release of mega platelets in the peripheral circulation by megakaryocytes, thus maintaining a good primary haemostasis. The speculated mechanisms leading to thrombocytopenia are: coagulation disturbances, splenomegaly, bone marrow alterations, antibody-mediated platelet destruction, oxidative stress and the role of platelets as cofactors in triggering severe malaria. Data from experimental models are presented and, despite not being rare, there is no clear recommendation on the adequate management of this haematological complication. In most cases, a conservative approach is adopted and platelet counts usually revert to normal ranges a few days after efficacious antimalarial treatment. More studies are needed to specifically clarify if thrombocytopenia is the cause or consequence of the clinical disease spectrum.Faculdade de Medicina (FMD)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_ThrombocytopeniaMalariaWho.pdfARTIGO_ThrombocytopeniaMalariaWho.pdfapplication/pdf889791http://repositorio2.unb.br/jspui/bitstream/10482/27974/1/ARTIGO_ThrombocytopeniaMalariaWho.pdf00096885d6fad1def00e47b7b4e7889bMD51open access10482/279742023-08-25 17:14:37.926open accessoai:repositorio2.unb.br:10482/27974Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-25T20:14:37Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Thrombocytopenia in malaria : who cares? |
title |
Thrombocytopenia in malaria : who cares? |
spellingShingle |
Thrombocytopenia in malaria : who cares? Lacerda, Marcus Vinícius Guimarães de Plasmodium falciparum Plasmodium vivax Malária Plaquetas |
title_short |
Thrombocytopenia in malaria : who cares? |
title_full |
Thrombocytopenia in malaria : who cares? |
title_fullStr |
Thrombocytopenia in malaria : who cares? |
title_full_unstemmed |
Thrombocytopenia in malaria : who cares? |
title_sort |
Thrombocytopenia in malaria : who cares? |
author |
Lacerda, Marcus Vinícius Guimarães de |
author_facet |
Lacerda, Marcus Vinícius Guimarães de Mourão, Maria Paula Gomes Coelho, Helena Cristina Cardoso Santos, João Barberino |
author_role |
author |
author2 |
Mourão, Maria Paula Gomes Coelho, Helena Cristina Cardoso Santos, João Barberino |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lacerda, Marcus Vinícius Guimarães de Mourão, Maria Paula Gomes Coelho, Helena Cristina Cardoso Santos, João Barberino |
dc.subject.keyword.pt_BR.fl_str_mv |
Plasmodium falciparum Plasmodium vivax Malária Plaquetas |
topic |
Plasmodium falciparum Plasmodium vivax Malária Plaquetas |
description |
Despite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria. In a systematic review of the literature, platelet counts under 150,000/mm³ ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. Minor bleeding is mentioned in case reports of patients with P. vivax infection and may be explained by medullary compensation with the release of mega platelets in the peripheral circulation by megakaryocytes, thus maintaining a good primary haemostasis. The speculated mechanisms leading to thrombocytopenia are: coagulation disturbances, splenomegaly, bone marrow alterations, antibody-mediated platelet destruction, oxidative stress and the role of platelets as cofactors in triggering severe malaria. Data from experimental models are presented and, despite not being rare, there is no clear recommendation on the adequate management of this haematological complication. In most cases, a conservative approach is adopted and platelet counts usually revert to normal ranges a few days after efficacious antimalarial treatment. More studies are needed to specifically clarify if thrombocytopenia is the cause or consequence of the clinical disease spectrum. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-08 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:56:11Z |
dc.date.available.fl_str_mv |
2017-12-07T04:56:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LACERDA, Marcus Vinícius Guimarães et al. Thrombocytopenia in malaria: who cares?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, supl. 1, p. 52-63, ago. 2011. DOI: https://doi.org/10.1590/S0074-02762011000900007. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900007&lng=en&nrm=iso. Acesso: 19 mar. 2021. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/27974 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S0074-02762011000900007 |
identifier_str_mv |
LACERDA, Marcus Vinícius Guimarães et al. Thrombocytopenia in malaria: who cares?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, supl. 1, p. 52-63, ago. 2011. DOI: https://doi.org/10.1590/S0074-02762011000900007. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900007&lng=en&nrm=iso. Acesso: 19 mar. 2021. |
url |
http://repositorio.unb.br/handle/10482/27974 https://dx.doi.org/10.1590/S0074-02762011000900007 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Repositório Institucional da UnB |
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