Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis

Detalhes bibliográficos
Autor(a) principal: Milioli, Maria Vitoria Meller
Data de Publicação: 2018
Outros Autores: Burger, Henrique, Olivieri, Rodrigo, Ávila, Pricila, Abatti, Mariane, Ritter, Cristiane
Idioma: por
Título da fonte: Repositório Institucional da UNESC
Texto Completo: http://repositorio.unesc.net/handle/1/6361
Resumo: Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC
id UNESC-1_31430d41a1745de34baef02ea274cc6c
oai_identifier_str oai:repositorio.unesc.net:1/6361
network_acronym_str UNESC-1
network_name_str Repositório Institucional da UNESC
spelling Milioli, Maria Vitoria MellerBurger, HenriqueOlivieri, RodrigoÁvila, PricilaAbatti, MarianeRitter, CristianeMichels, MoniquePizzol, Felipe DalUniversidade do Extremo Sul Catarinense2018-11-08T10:31:29Z2018-11-08T10:31:29Z2018-07http://repositorio.unesc.net/handle/1/6361Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESCThis study aimed to evaluate behavioral and neurochemical parameters in old and young rats submitted to sepsis. Young (60 days) and old animals (180 days) (n=40) were submitted to sham or sepsis. Some behavioral tests were performed; Immunohistochemistry, western blotting, oxidative stress and cytokines levels were measured in hippocampus and pre-frontal. Behavioral tests have showed decline of cognitive function. β-amyloid levels were increased in old rats in both groups. Cytokines levels are altered in old animals. MDA equivalents were increased in old rats all times. Our data show that systemic inflammation has additive effect on the physiological process of aging, with more expression of pro inflammatory cytokines and more oxidative stress.SepsisAgingImmunosenescenceSystemic inflammationNeurochemistrySepseEnvelhecimentoImunosenescênciaInflamação sistêmicaNeuroquímicaEvaluation of behavioral and neurochemical parameters in old rats submitted to sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisporreponame:Repositório Institucional da UNESCinstname:Universidade do Extremo Sul Catarinense (Unesc)instacron:UNESCinfo:eu-repo/semantics/openAccessORIGINALInformação do texto competo - Medicina.pdfInformação do texto competo - Medicina.pdfArtigoapplication/pdf4584http://repositorio.unesc.net/bitstream/1/6361/1/Informa%c3%a7%c3%a3o%20do%20texto%20competo%20-%20Medicina.pdf1c6e9dc40d415f218ecfb092b602798eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.unesc.net/bitstream/1/6361/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD521/63612018-11-08 08:31:34.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Repositório de Publicaçõeshttp://repositorio.unesc.net/
dc.title.pt_BR.fl_str_mv Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
title Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
spellingShingle Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
Milioli, Maria Vitoria Meller
Sepsis
Aging
Immunosenescence
Systemic inflammation
Neurochemistry
Sepse
Envelhecimento
Imunosenescência
Inflamação sistêmica
Neuroquímica
title_short Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
title_full Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
title_fullStr Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
title_full_unstemmed Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
title_sort Evaluation of behavioral and neurochemical parameters in old rats submitted to sepsis
author Milioli, Maria Vitoria Meller
author_facet Milioli, Maria Vitoria Meller
Burger, Henrique
Olivieri, Rodrigo
Ávila, Pricila
Abatti, Mariane
Ritter, Cristiane
author_role author
author2 Burger, Henrique
Olivieri, Rodrigo
Ávila, Pricila
Abatti, Mariane
Ritter, Cristiane
author2_role author
author
author
author
author
dc.contributor.other.none.fl_str_mv Michels, Monique
dc.contributor.author.fl_str_mv Milioli, Maria Vitoria Meller
Burger, Henrique
Olivieri, Rodrigo
Ávila, Pricila
Abatti, Mariane
Ritter, Cristiane
dc.contributor.advisor1.fl_str_mv Pizzol, Felipe Dal
contributor_str_mv Pizzol, Felipe Dal
dc.subject.por.fl_str_mv Sepsis
Aging
Immunosenescence
Systemic inflammation
Neurochemistry
Sepse
Envelhecimento
Imunosenescência
Inflamação sistêmica
Neuroquímica
topic Sepsis
Aging
Immunosenescence
Systemic inflammation
Neurochemistry
Sepse
Envelhecimento
Imunosenescência
Inflamação sistêmica
Neuroquímica
dc.description.pt_BR.fl_txt_mv Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC
dc.description.abstract.por.fl_txt_mv This study aimed to evaluate behavioral and neurochemical parameters in old and young rats submitted to sepsis. Young (60 days) and old animals (180 days) (n=40) were submitted to sham or sepsis. Some behavioral tests were performed; Immunohistochemistry, western blotting, oxidative stress and cytokines levels were measured in hippocampus and pre-frontal. Behavioral tests have showed decline of cognitive function. β-amyloid levels were increased in old rats in both groups. Cytokines levels are altered in old animals. MDA equivalents were increased in old rats all times. Our data show that systemic inflammation has additive effect on the physiological process of aging, with more expression of pro inflammatory cytokines and more oxidative stress.
description Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-11-08T10:31:29Z
dc.date.available.fl_str_mv 2018-11-08T10:31:29Z
dc.date.created.fl_str_mv 2018-07
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.unesc.net/handle/1/6361
url http://repositorio.unesc.net/handle/1/6361
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.coverage.spatial.pt_BR.fl_str_mv Universidade do Extremo Sul Catarinense
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESC
instname:Universidade do Extremo Sul Catarinense (Unesc)
instacron:UNESC
instname_str Universidade do Extremo Sul Catarinense (Unesc)
instacron_str UNESC
institution UNESC
reponame_str Repositório Institucional da UNESC
collection Repositório Institucional da UNESC
bitstream.url.fl_str_mv http://repositorio.unesc.net/bitstream/1/6361/1/Informa%c3%a7%c3%a3o%20do%20texto%20competo%20-%20Medicina.pdf
http://repositorio.unesc.net/bitstream/1/6361/2/license.txt
bitstream.checksum.fl_str_mv 1c6e9dc40d415f218ecfb092b602798e
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1725763258209533952

Registros relacionados