Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom

Detalhes bibliográficos
Autor(a) principal: Barão,A. A. S.
Data de Publicação: 2008
Outros Autores: Nencioni,A. L. A., Dorce,V. A. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010
Resumo: Tityus serrulatus is the most venomous scorpion in Brazil; however, it is not known whether its venom causes any harm to the offspring whose mothers have received it. This study investigates whether the venom of T. serrulatus may lead to deleterious effects in the offspring, when once administered to pregnant rats at a dose that causes moderate envenomation (3mg/kg). The venom effects were studied on the 5th and on the 10th gestation day (GD5 and GD10). The maternal reproductive parameters of the group that received the venom on GD5 showed no alteration. The group that received the venom on GD10 presented an increase in post-implantation losses. In this group, an increase in the liver weight was also observed and one-third of the fetuses presented incomplete ossification of skull bones. None of the groups that received the venom had any visceral malformation or delay in the fetal development of their offspring. The histopathological analysis revealed not only placentas and lungs but also hearts, livers and kidneys in perfect state. Even having caused little effect on the dams, the venom may act in a more incisive way on the offspring, whether by stress generation or by a direct action.
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spelling Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venomscorpion venomperinatalTityus serrulatuspregnancyembryofetotoxicityTityus serrulatus is the most venomous scorpion in Brazil; however, it is not known whether its venom causes any harm to the offspring whose mothers have received it. This study investigates whether the venom of T. serrulatus may lead to deleterious effects in the offspring, when once administered to pregnant rats at a dose that causes moderate envenomation (3mg/kg). The venom effects were studied on the 5th and on the 10th gestation day (GD5 and GD10). The maternal reproductive parameters of the group that received the venom on GD5 showed no alteration. The group that received the venom on GD10 presented an increase in post-implantation losses. In this group, an increase in the liver weight was also observed and one-third of the fetuses presented incomplete ossification of skull bones. None of the groups that received the venom had any visceral malformation or delay in the fetal development of their offspring. The histopathological analysis revealed not only placentas and lungs but also hearts, livers and kidneys in perfect state. Even having caused little effect on the dams, the venom may act in a more incisive way on the offspring, whether by stress generation or by a direct action.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.2 2008reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992008000200010info:eu-repo/semantics/openAccessBarão,A. A. S.Nencioni,A. L. A.Dorce,V. A. C.eng2008-06-16T00:00:00Zoai:scielo:S1678-91992008000200010Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2008-06-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
title Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
spellingShingle Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
Barão,A. A. S.
scorpion venom
perinatal
Tityus serrulatus
pregnancy
embryofetotoxicity
title_short Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
title_full Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
title_fullStr Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
title_full_unstemmed Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
title_sort Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom
author Barão,A. A. S.
author_facet Barão,A. A. S.
Nencioni,A. L. A.
Dorce,V. A. C.
author_role author
author2 Nencioni,A. L. A.
Dorce,V. A. C.
author2_role author
author
dc.contributor.author.fl_str_mv Barão,A. A. S.
Nencioni,A. L. A.
Dorce,V. A. C.
dc.subject.por.fl_str_mv scorpion venom
perinatal
Tityus serrulatus
pregnancy
embryofetotoxicity
topic scorpion venom
perinatal
Tityus serrulatus
pregnancy
embryofetotoxicity
description Tityus serrulatus is the most venomous scorpion in Brazil; however, it is not known whether its venom causes any harm to the offspring whose mothers have received it. This study investigates whether the venom of T. serrulatus may lead to deleterious effects in the offspring, when once administered to pregnant rats at a dose that causes moderate envenomation (3mg/kg). The venom effects were studied on the 5th and on the 10th gestation day (GD5 and GD10). The maternal reproductive parameters of the group that received the venom on GD5 showed no alteration. The group that received the venom on GD10 presented an increase in post-implantation losses. In this group, an increase in the liver weight was also observed and one-third of the fetuses presented incomplete ossification of skull bones. None of the groups that received the venom had any visceral malformation or delay in the fetal development of their offspring. The histopathological analysis revealed not only placentas and lungs but also hearts, livers and kidneys in perfect state. Even having caused little effect on the dams, the venom may act in a more incisive way on the offspring, whether by stress generation or by a direct action.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992008000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.2 2008
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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