Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis

Detalhes bibliográficos
Autor(a) principal: Liu,ZH
Data de Publicação: 2009
Outros Autores: Qian,W, Li,J, Zhang,Y, Liang,S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008
Resumo: The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells.
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spelling Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensisspiderLycosa singoriensiscrude venomMALDI-TOFantimicrobial activityThe wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008Journal of Venomous Animals and Toxins including Tropical Diseases v.15 n.1 2009reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992009000100008info:eu-repo/semantics/openAccessLiu,ZHQian,WLi,JZhang,YLiang,Seng2009-03-16T00:00:00Zoai:scielo:S1678-91992009000100008Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2009-03-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
title Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
spellingShingle Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
Liu,ZH
spider
Lycosa singoriensis
crude venom
MALDI-TOF
antimicrobial activity
title_short Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
title_full Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
title_fullStr Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
title_full_unstemmed Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
title_sort Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
author Liu,ZH
author_facet Liu,ZH
Qian,W
Li,J
Zhang,Y
Liang,S
author_role author
author2 Qian,W
Li,J
Zhang,Y
Liang,S
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Liu,ZH
Qian,W
Li,J
Zhang,Y
Liang,S
dc.subject.por.fl_str_mv spider
Lycosa singoriensis
crude venom
MALDI-TOF
antimicrobial activity
topic spider
Lycosa singoriensis
crude venom
MALDI-TOF
antimicrobial activity
description The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992009000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.15 n.1 2009
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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