Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

Detalhes bibliográficos
Autor(a) principal: Oliveira,Isadora S
Data de Publicação: 2019
Outros Autores: Ferreira,Isabela G, Alexandre-Silva,Gabriel M, Cerni,Felipe A, Cremonez,Caroline M, Arantes,Eliane C, Zottich,Umberto, Pucca,Manuela B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202
Resumo: Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases.
id UNESP-11_91aa8df30e825193853fa634c0195a16
oai_identifier_str oai:scielo:S1678-91992019000100202
network_acronym_str UNESP-11
network_name_str The Journal of venomous animals and toxins including tropical diseases (Online)
repository_id_str
spelling Scorpion toxins targeting Kv1.3 channels: insights into immunosuppressionvoltage-gated potassium channelsKv1.3scorpion toxinsKTximmunosuppressionAbstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/1678-9199-jvatitd-1481-18info:eu-repo/semantics/openAccessOliveira,Isadora SFerreira,Isabela GAlexandre-Silva,Gabriel MCerni,Felipe ACremonez,Caroline MArantes,Eliane CZottich,UmbertoPucca,Manuela Beng2019-07-04T00:00:00Zoai:scielo:S1678-91992019000100202Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2019-07-04T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
title Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
spellingShingle Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Oliveira,Isadora S
voltage-gated potassium channels
Kv1.3
scorpion toxins
KTx
immunosuppression
title_short Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
title_full Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
title_fullStr Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
title_full_unstemmed Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
title_sort Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
author Oliveira,Isadora S
author_facet Oliveira,Isadora S
Ferreira,Isabela G
Alexandre-Silva,Gabriel M
Cerni,Felipe A
Cremonez,Caroline M
Arantes,Eliane C
Zottich,Umberto
Pucca,Manuela B
author_role author
author2 Ferreira,Isabela G
Alexandre-Silva,Gabriel M
Cerni,Felipe A
Cremonez,Caroline M
Arantes,Eliane C
Zottich,Umberto
Pucca,Manuela B
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Isadora S
Ferreira,Isabela G
Alexandre-Silva,Gabriel M
Cerni,Felipe A
Cremonez,Caroline M
Arantes,Eliane C
Zottich,Umberto
Pucca,Manuela B
dc.subject.por.fl_str_mv voltage-gated potassium channels
Kv1.3
scorpion toxins
KTx
immunosuppression
topic voltage-gated potassium channels
Kv1.3
scorpion toxins
KTx
immunosuppression
description Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-9199-jvatitd-1481-18
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
_version_ 1748958540545916928