Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202 |
Resumo: | Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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Scorpion toxins targeting Kv1.3 channels: insights into immunosuppressionvoltage-gated potassium channelsKv1.3scorpion toxinsKTximmunosuppressionAbstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/1678-9199-jvatitd-1481-18info:eu-repo/semantics/openAccessOliveira,Isadora SFerreira,Isabela GAlexandre-Silva,Gabriel MCerni,Felipe ACremonez,Caroline MArantes,Eliane CZottich,UmbertoPucca,Manuela Beng2019-07-04T00:00:00Zoai:scielo:S1678-91992019000100202Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2019-07-04T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
spellingShingle |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression Oliveira,Isadora S voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression |
title_short |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_full |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_fullStr |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_full_unstemmed |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_sort |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
author |
Oliveira,Isadora S |
author_facet |
Oliveira,Isadora S Ferreira,Isabela G Alexandre-Silva,Gabriel M Cerni,Felipe A Cremonez,Caroline M Arantes,Eliane C Zottich,Umberto Pucca,Manuela B |
author_role |
author |
author2 |
Ferreira,Isabela G Alexandre-Silva,Gabriel M Cerni,Felipe A Cremonez,Caroline M Arantes,Eliane C Zottich,Umberto Pucca,Manuela B |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Isadora S Ferreira,Isabela G Alexandre-Silva,Gabriel M Cerni,Felipe A Cremonez,Caroline M Arantes,Eliane C Zottich,Umberto Pucca,Manuela B |
dc.subject.por.fl_str_mv |
voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression |
topic |
voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression |
description |
Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-9199-jvatitd-1481-18 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958540545916928 |