Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting

Detalhes bibliográficos
Autor(a) principal: Almeida,R. A. M. B.
Data de Publicação: 2007
Outros Autores: Silva,G. F., Llanos,J. C., Winckler,C. C., Gomes,M. R. B., Biagioni,D. S., Paula,R. C. C., Meira,D. A., Bakonyi,A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400016
Resumo: Cytomegalovirus (CMV) disease is a major cause of morbidity and mortality in solid organ transplantation. Disseminated toxoplasmosis after liver transplantation is a rare but fatal event. Serologic screening of the donor and the recipient is essential to prophylactic management, early diagnosis and therapeutic strategies to minimize the consequences of these infections. The aim of the present study was to determine the seroprevalence of CMV and Toxoplasma gondii (TG) in a Brazilian liver transplant waiting list (LTWL). Serological data were collected from 44 candidates on the LTWL between May 2003 and November 2004. Serological investigation of antibodies IgM and IgG against CMV (anti-CMV) and TG (anti-T. gondii) was performed using fluorometry commercial kits. IgG anti-CMV was positive in 37 patients (94.9%) out of 39 available results. There were not IgM anti-CMV positive results. Out of 36 analyzed patients, 22 (61.1%) presented positive IgG anti-T. gondii and none had positive IgM anti-T. gondii. The high CMV seroprevalence among our LTWL reinforces the need for appropriate protocols to avoid related complications, like reactivation and superinfection by CMV. Environmental and drug prophylactic strategies against primary infection and reactivation, as well as early diagnosis and treatment of toxoplasmosis complications, are essential for the good outcome of transplant patients.
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spelling Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waitingCytomegalovirusliver transplantationtoxoplasmosisToxoplasma gondiiseroprevalencewaiting listCytomegalovirus (CMV) disease is a major cause of morbidity and mortality in solid organ transplantation. Disseminated toxoplasmosis after liver transplantation is a rare but fatal event. Serologic screening of the donor and the recipient is essential to prophylactic management, early diagnosis and therapeutic strategies to minimize the consequences of these infections. The aim of the present study was to determine the seroprevalence of CMV and Toxoplasma gondii (TG) in a Brazilian liver transplant waiting list (LTWL). Serological data were collected from 44 candidates on the LTWL between May 2003 and November 2004. Serological investigation of antibodies IgM and IgG against CMV (anti-CMV) and TG (anti-T. gondii) was performed using fluorometry commercial kits. IgG anti-CMV was positive in 37 patients (94.9%) out of 39 available results. There were not IgM anti-CMV positive results. Out of 36 analyzed patients, 22 (61.1%) presented positive IgG anti-T. gondii and none had positive IgM anti-T. gondii. The high CMV seroprevalence among our LTWL reinforces the need for appropriate protocols to avoid related complications, like reactivation and superinfection by CMV. Environmental and drug prophylactic strategies against primary infection and reactivation, as well as early diagnosis and treatment of toxoplasmosis complications, are essential for the good outcome of transplant patients.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400016Journal of Venomous Animals and Toxins including Tropical Diseases v.13 n.4 2007reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992007000400016info:eu-repo/semantics/openAccessAlmeida,R. A. M. B.Silva,G. F.Llanos,J. C.Winckler,C. C.Gomes,M. R. B.Biagioni,D. S.Paula,R. C. C.Meira,D. A.Bakonyi,A.eng2007-12-19T00:00:00Zoai:scielo:S1678-91992007000400016Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2007-12-19T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
title Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
spellingShingle Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
Almeida,R. A. M. B.
Cytomegalovirus
liver transplantation
toxoplasmosis
Toxoplasma gondii
seroprevalence
waiting list
title_short Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
title_full Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
title_fullStr Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
title_full_unstemmed Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
title_sort Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting
author Almeida,R. A. M. B.
author_facet Almeida,R. A. M. B.
Silva,G. F.
Llanos,J. C.
Winckler,C. C.
Gomes,M. R. B.
Biagioni,D. S.
Paula,R. C. C.
Meira,D. A.
Bakonyi,A.
author_role author
author2 Silva,G. F.
Llanos,J. C.
Winckler,C. C.
Gomes,M. R. B.
Biagioni,D. S.
Paula,R. C. C.
Meira,D. A.
Bakonyi,A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida,R. A. M. B.
Silva,G. F.
Llanos,J. C.
Winckler,C. C.
Gomes,M. R. B.
Biagioni,D. S.
Paula,R. C. C.
Meira,D. A.
Bakonyi,A.
dc.subject.por.fl_str_mv Cytomegalovirus
liver transplantation
toxoplasmosis
Toxoplasma gondii
seroprevalence
waiting list
topic Cytomegalovirus
liver transplantation
toxoplasmosis
Toxoplasma gondii
seroprevalence
waiting list
description Cytomegalovirus (CMV) disease is a major cause of morbidity and mortality in solid organ transplantation. Disseminated toxoplasmosis after liver transplantation is a rare but fatal event. Serologic screening of the donor and the recipient is essential to prophylactic management, early diagnosis and therapeutic strategies to minimize the consequences of these infections. The aim of the present study was to determine the seroprevalence of CMV and Toxoplasma gondii (TG) in a Brazilian liver transplant waiting list (LTWL). Serological data were collected from 44 candidates on the LTWL between May 2003 and November 2004. Serological investigation of antibodies IgM and IgG against CMV (anti-CMV) and TG (anti-T. gondii) was performed using fluorometry commercial kits. IgG anti-CMV was positive in 37 patients (94.9%) out of 39 available results. There were not IgM anti-CMV positive results. Out of 36 analyzed patients, 22 (61.1%) presented positive IgG anti-T. gondii and none had positive IgM anti-T. gondii. The high CMV seroprevalence among our LTWL reinforces the need for appropriate protocols to avoid related complications, like reactivation and superinfection by CMV. Environmental and drug prophylactic strategies against primary infection and reactivation, as well as early diagnosis and treatment of toxoplasmosis complications, are essential for the good outcome of transplant patients.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992007000400016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.13 n.4 2007
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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