DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Detalhes bibliográficos
Autor(a) principal: Barbosa,Adriana Sierra Assencio Almeida
Data de Publicação: 2015
Outros Autores: Oliveira,Larissa Ragozo Cardoso de, Tavares,Francilene Capel, Lima,Carlos Roberto Gonçalves de, Diório,Suzana Madeira, Calvi,Sueli Aparecida, Vilani-Moreno,Fátima Regina, Pereira,Paulo Câmara Marques
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317
Resumo: AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
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spelling DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional statusJorge Lobo’ diseaseLacazia loboiMalnutritionMiceGenotoxicityComet assayAbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-015-0006-yinfo:eu-repo/semantics/openAccessBarbosa,Adriana Sierra Assencio AlmeidaOliveira,Larissa Ragozo Cardoso deTavares,Francilene CapelLima,Carlos Roberto Gonçalves deDiório,Suzana MadeiraCalvi,Sueli AparecidaVilani-Moreno,Fátima ReginaPereira,Paulo Câmara Marqueseng2015-08-20T00:00:00Zoai:scielo:S1678-91992015000100317Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2015-08-20T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
title DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
spellingShingle DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Barbosa,Adriana Sierra Assencio Almeida
Jorge Lobo’ disease
Lacazia loboi
Malnutrition
Mice
Genotoxicity
Comet assay
title_short DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
title_full DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
title_fullStr DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
title_full_unstemmed DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
title_sort DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
author Barbosa,Adriana Sierra Assencio Almeida
author_facet Barbosa,Adriana Sierra Assencio Almeida
Oliveira,Larissa Ragozo Cardoso de
Tavares,Francilene Capel
Lima,Carlos Roberto Gonçalves de
Diório,Suzana Madeira
Calvi,Sueli Aparecida
Vilani-Moreno,Fátima Regina
Pereira,Paulo Câmara Marques
author_role author
author2 Oliveira,Larissa Ragozo Cardoso de
Tavares,Francilene Capel
Lima,Carlos Roberto Gonçalves de
Diório,Suzana Madeira
Calvi,Sueli Aparecida
Vilani-Moreno,Fátima Regina
Pereira,Paulo Câmara Marques
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa,Adriana Sierra Assencio Almeida
Oliveira,Larissa Ragozo Cardoso de
Tavares,Francilene Capel
Lima,Carlos Roberto Gonçalves de
Diório,Suzana Madeira
Calvi,Sueli Aparecida
Vilani-Moreno,Fátima Regina
Pereira,Paulo Câmara Marques
dc.subject.por.fl_str_mv Jorge Lobo’ disease
Lacazia loboi
Malnutrition
Mice
Genotoxicity
Comet assay
topic Jorge Lobo’ disease
Lacazia loboi
Malnutrition
Mice
Genotoxicity
Comet assay
description AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/s40409-015-0006-y
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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