DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317 |
Resumo: | AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional statusJorge Lobo’ diseaseLacazia loboiMalnutritionMiceGenotoxicityComet assayAbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-015-0006-yinfo:eu-repo/semantics/openAccessBarbosa,Adriana Sierra Assencio AlmeidaOliveira,Larissa Ragozo Cardoso deTavares,Francilene CapelLima,Carlos Roberto Gonçalves deDiório,Suzana MadeiraCalvi,Sueli AparecidaVilani-Moreno,Fátima ReginaPereira,Paulo Câmara Marqueseng2015-08-20T00:00:00Zoai:scielo:S1678-91992015000100317Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2015-08-20T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
title |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
spellingShingle |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status Barbosa,Adriana Sierra Assencio Almeida Jorge Lobo’ disease Lacazia loboi Malnutrition Mice Genotoxicity Comet assay |
title_short |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
title_full |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
title_fullStr |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
title_full_unstemmed |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
title_sort |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status |
author |
Barbosa,Adriana Sierra Assencio Almeida |
author_facet |
Barbosa,Adriana Sierra Assencio Almeida Oliveira,Larissa Ragozo Cardoso de Tavares,Francilene Capel Lima,Carlos Roberto Gonçalves de Diório,Suzana Madeira Calvi,Sueli Aparecida Vilani-Moreno,Fátima Regina Pereira,Paulo Câmara Marques |
author_role |
author |
author2 |
Oliveira,Larissa Ragozo Cardoso de Tavares,Francilene Capel Lima,Carlos Roberto Gonçalves de Diório,Suzana Madeira Calvi,Sueli Aparecida Vilani-Moreno,Fátima Regina Pereira,Paulo Câmara Marques |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa,Adriana Sierra Assencio Almeida Oliveira,Larissa Ragozo Cardoso de Tavares,Francilene Capel Lima,Carlos Roberto Gonçalves de Diório,Suzana Madeira Calvi,Sueli Aparecida Vilani-Moreno,Fátima Regina Pereira,Paulo Câmara Marques |
dc.subject.por.fl_str_mv |
Jorge Lobo’ disease Lacazia loboi Malnutrition Mice Genotoxicity Comet assay |
topic |
Jorge Lobo’ disease Lacazia loboi Malnutrition Mice Genotoxicity Comet assay |
description |
AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1186/s40409-015-0006-y |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958539966054400 |