Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200010 |
Resumo: | A cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9%. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosis infection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative reaction to the tuberculin skin test is probably related to alterations in the cellular immune response induced by HIV infection. The tuberculin test is a useful tool for the detection of latent tuberculosis infection and should be performed in all HIV/AIDS individuals at the time of the diagnosis and on a yearly basis, if negative. Both the early identification of the tuberculosis infection by the tuberculin skin test at the moment of immunological restoration and chemoprophylaxis in infected individuals are mechanisms to control HIV/AIDS and tuberculosis coinfection. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Braziltuberculin skin testacquired immunodeficiency syndromeCD4/CD8 cell countA cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9%. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosis infection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative reaction to the tuberculin skin test is probably related to alterations in the cellular immune response induced by HIV infection. The tuberculin test is a useful tool for the detection of latent tuberculosis infection and should be performed in all HIV/AIDS individuals at the time of the diagnosis and on a yearly basis, if negative. Both the early identification of the tuberculosis infection by the tuberculin skin test at the moment of immunological restoration and chemoprophylaxis in infected individuals are mechanisms to control HIV/AIDS and tuberculosis coinfection.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200010Journal of Venomous Animals and Toxins including Tropical Diseases v.16 n.2 2010reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992010000200010info:eu-repo/semantics/openAccessDe Oliveira,SMVLPaniago,AMMBonecini-Almeida,MGBertoni,NStabile,ACDa Cunha,RVDe Oliveira,OADruzian,AFNegri,ACAndreotti,Reng2010-06-11T00:00:00Zoai:scielo:S1678-91992010000200010Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2010-06-11T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
title |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
spellingShingle |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil De Oliveira,SMVL tuberculin skin test acquired immunodeficiency syndrome CD4/CD8 cell count |
title_short |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
title_full |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
title_fullStr |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
title_full_unstemmed |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
title_sort |
Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil |
author |
De Oliveira,SMVL |
author_facet |
De Oliveira,SMVL Paniago,AMM Bonecini-Almeida,MG Bertoni,N Stabile,AC Da Cunha,RV De Oliveira,OA Druzian,AF Negri,AC Andreotti,R |
author_role |
author |
author2 |
Paniago,AMM Bonecini-Almeida,MG Bertoni,N Stabile,AC Da Cunha,RV De Oliveira,OA Druzian,AF Negri,AC Andreotti,R |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
De Oliveira,SMVL Paniago,AMM Bonecini-Almeida,MG Bertoni,N Stabile,AC Da Cunha,RV De Oliveira,OA Druzian,AF Negri,AC Andreotti,R |
dc.subject.por.fl_str_mv |
tuberculin skin test acquired immunodeficiency syndrome CD4/CD8 cell count |
topic |
tuberculin skin test acquired immunodeficiency syndrome CD4/CD8 cell count |
description |
A cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9%. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosis infection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative reaction to the tuberculin skin test is probably related to alterations in the cellular immune response induced by HIV infection. The tuberculin test is a useful tool for the detection of latent tuberculosis infection and should be performed in all HIV/AIDS individuals at the time of the diagnosis and on a yearly basis, if negative. Both the early identification of the tuberculosis infection by the tuberculin skin test at the moment of immunological restoration and chemoprophylaxis in infected individuals are mechanisms to control HIV/AIDS and tuberculosis coinfection. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-91992010000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.16 n.2 2010 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958538758094848 |