Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice

Detalhes bibliográficos
Autor(a) principal: Chaubey,MK
Data de Publicação: 2010
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300011
Resumo: The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae) venom on albino mice (NIH strain). Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP), lactic dehydrogenase (LDH) and alanine aminotransferase (ALT) in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.
id UNESP-11_cb26dae3ebf8282aad6de8bda1cc310c
oai_identifier_str oai:scielo:S1678-91992010000300011
network_acronym_str UNESP-11
network_name_str The Journal of venomous animals and toxins including tropical diseases (Online)
repository_id_str
spelling Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino miceMesobuthus tamulus gangeticusscorpion venomhyperglycemiaserum enzymesThe present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae) venom on albino mice (NIH strain). Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP), lactic dehydrogenase (LDH) and alanine aminotransferase (ALT) in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300011Journal of Venomous Animals and Toxins including Tropical Diseases v.16 n.3 2010reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992010000300011info:eu-repo/semantics/openAccessChaubey,MKeng2010-08-30T00:00:00Zoai:scielo:S1678-91992010000300011Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2010-08-30T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
title Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
spellingShingle Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
Chaubey,MK
Mesobuthus tamulus gangeticus
scorpion venom
hyperglycemia
serum enzymes
title_short Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
title_full Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
title_fullStr Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
title_full_unstemmed Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
title_sort Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
author Chaubey,MK
author_facet Chaubey,MK
author_role author
dc.contributor.author.fl_str_mv Chaubey,MK
dc.subject.por.fl_str_mv Mesobuthus tamulus gangeticus
scorpion venom
hyperglycemia
serum enzymes
topic Mesobuthus tamulus gangeticus
scorpion venom
hyperglycemia
serum enzymes
description The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae) venom on albino mice (NIH strain). Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection. Moreover, M. tamulus gangeticus venom elevated the enzymatic activity of acid phosphatase (ACP), lactic dehydrogenase (LDH) and alanine aminotransferase (ALT) in the serum of albino mice. In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992010000300011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.16 n.3 2010
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
_version_ 1748958538780114944

Registros relacionados