Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100212 |
Resumo: | The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and pathological anxiety. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disordersThe impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and pathological anxiety.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100212Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-015-0031-xinfo:eu-repo/semantics/openAccessMonge-Fuentes,VictoriaGomes,Flávia Maria MedeirosCampos,Gabriel Avohay AlvesSilva,Juliana de CastroBiolchi,Andréia MayerAnjos,Lilian Carneiro dosGonçalves,Jacqueline CoimbraLopes,Kamila SoaresMortari,Márcia Renataeng2015-09-24T00:00:00Zoai:scielo:S1678-91992015000100212Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2015-09-24T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
title |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
spellingShingle |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders Monge-Fuentes,Victoria |
title_short |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
title_full |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
title_fullStr |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
title_full_unstemmed |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
title_sort |
Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders |
author |
Monge-Fuentes,Victoria |
author_facet |
Monge-Fuentes,Victoria Gomes,Flávia Maria Medeiros Campos,Gabriel Avohay Alves Silva,Juliana de Castro Biolchi,Andréia Mayer Anjos,Lilian Carneiro dos Gonçalves,Jacqueline Coimbra Lopes,Kamila Soares Mortari,Márcia Renata |
author_role |
author |
author2 |
Gomes,Flávia Maria Medeiros Campos,Gabriel Avohay Alves Silva,Juliana de Castro Biolchi,Andréia Mayer Anjos,Lilian Carneiro dos Gonçalves,Jacqueline Coimbra Lopes,Kamila Soares Mortari,Márcia Renata |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Monge-Fuentes,Victoria Gomes,Flávia Maria Medeiros Campos,Gabriel Avohay Alves Silva,Juliana de Castro Biolchi,Andréia Mayer Anjos,Lilian Carneiro dos Gonçalves,Jacqueline Coimbra Lopes,Kamila Soares Mortari,Márcia Renata |
description |
The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and pathological anxiety. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100212 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1186/s40409-015-0031-x |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958539672453120 |