The biocompatibility of a new endodontic paste used in dental trauma
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Odontologia da UNESP |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772015000400232 |
Resumo: | AbstractObjectiveThis study investigated the short-term subcutaneous tissue reaction of a new endodontic paste, based on the association among calcium hydroxide [Ca(OH)2], 2% chlorhexidine gel (CHX) and zinc oxide (ZnO) in comparison with a control paste, and the individual substances alone.Material and methodTwenty-four male wistar rats were used. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of rats. Empty implanted tubes served as controls. The materials used were: Ca(OH)2+CHX+ZnO paste in two different proportions (2:1:2) and (2:1:3), a control paste, Ca(OH)2+CHX (2:1), and the substances alone. After time intervals of 2, 3, 7 and 15 days, the animals were euthanized and the specimens prepared for histological processing. Data were evaluated qualitatively according to the levels of tissue repair and the degree of inflammation.ResultOn the second day all the materials were observed to cause a severe inflammatory response. On the third day, the pastes Ca(OH)2+CHX+ZnO (2:1:2) and (2:1:3) showed reduction in degree of inflammation. On seventh day the tissue was already more organized with presence of collagen fibers in all materials. After 15 days it was found that compound Ca(OH)2+CHX+ZnO (2:1:2) showed areas with no inflammatory infiltrate.ConclusionThe experimental pastes, Ca(OH)2+CHX+ZnO in two different proportions (2:1:2) and (2:1:3), showed favorable results with respect to biocompatibility, when evaluated for a short-term. |
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The biocompatibility of a new endodontic paste used in dental traumaMaterials testingchlorhexidinecalcium hydroxidezinc oxidetoxicityAbstractObjectiveThis study investigated the short-term subcutaneous tissue reaction of a new endodontic paste, based on the association among calcium hydroxide [Ca(OH)2], 2% chlorhexidine gel (CHX) and zinc oxide (ZnO) in comparison with a control paste, and the individual substances alone.Material and methodTwenty-four male wistar rats were used. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of rats. Empty implanted tubes served as controls. The materials used were: Ca(OH)2+CHX+ZnO paste in two different proportions (2:1:2) and (2:1:3), a control paste, Ca(OH)2+CHX (2:1), and the substances alone. After time intervals of 2, 3, 7 and 15 days, the animals were euthanized and the specimens prepared for histological processing. Data were evaluated qualitatively according to the levels of tissue repair and the degree of inflammation.ResultOn the second day all the materials were observed to cause a severe inflammatory response. On the third day, the pastes Ca(OH)2+CHX+ZnO (2:1:2) and (2:1:3) showed reduction in degree of inflammation. On seventh day the tissue was already more organized with presence of collagen fibers in all materials. After 15 days it was found that compound Ca(OH)2+CHX+ZnO (2:1:2) showed areas with no inflammatory infiltrate.ConclusionThe experimental pastes, Ca(OH)2+CHX+ZnO in two different proportions (2:1:2) and (2:1:3), showed favorable results with respect to biocompatibility, when evaluated for a short-term.Universidade Estadual Paulista Júlio de Mesquita Filho2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772015000400232Revista de Odontologia da UNESP v.44 n.4 2015reponame:Revista de Odontologia da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/1807-2577.0079info:eu-repo/semantics/openAccessSoares,Adriana de JesusPrado,Maíra doBrazão,Mariana AmadeGomes,Brenda Paula Figueiredo de AlmeidaZaia,Alexandre Augustoeng2015-10-27T00:00:00Zoai:scielo:S1807-25772015000400232Revistahttps://www.revodontolunesp.com.br/PUBhttps://old.scielo.br/oai/scielo-oai.php||adriana@foar.unesp.br1807-25770101-1774opendoar:2015-10-27T00:00Revista de Odontologia da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The biocompatibility of a new endodontic paste used in dental trauma |
title |
The biocompatibility of a new endodontic paste used in dental trauma |
spellingShingle |
The biocompatibility of a new endodontic paste used in dental trauma Soares,Adriana de Jesus Materials testing chlorhexidine calcium hydroxide zinc oxide toxicity |
title_short |
The biocompatibility of a new endodontic paste used in dental trauma |
title_full |
The biocompatibility of a new endodontic paste used in dental trauma |
title_fullStr |
The biocompatibility of a new endodontic paste used in dental trauma |
title_full_unstemmed |
The biocompatibility of a new endodontic paste used in dental trauma |
title_sort |
The biocompatibility of a new endodontic paste used in dental trauma |
author |
Soares,Adriana de Jesus |
author_facet |
Soares,Adriana de Jesus Prado,Maíra do Brazão,Mariana Amade Gomes,Brenda Paula Figueiredo de Almeida Zaia,Alexandre Augusto |
author_role |
author |
author2 |
Prado,Maíra do Brazão,Mariana Amade Gomes,Brenda Paula Figueiredo de Almeida Zaia,Alexandre Augusto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Soares,Adriana de Jesus Prado,Maíra do Brazão,Mariana Amade Gomes,Brenda Paula Figueiredo de Almeida Zaia,Alexandre Augusto |
dc.subject.por.fl_str_mv |
Materials testing chlorhexidine calcium hydroxide zinc oxide toxicity |
topic |
Materials testing chlorhexidine calcium hydroxide zinc oxide toxicity |
description |
AbstractObjectiveThis study investigated the short-term subcutaneous tissue reaction of a new endodontic paste, based on the association among calcium hydroxide [Ca(OH)2], 2% chlorhexidine gel (CHX) and zinc oxide (ZnO) in comparison with a control paste, and the individual substances alone.Material and methodTwenty-four male wistar rats were used. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of rats. Empty implanted tubes served as controls. The materials used were: Ca(OH)2+CHX+ZnO paste in two different proportions (2:1:2) and (2:1:3), a control paste, Ca(OH)2+CHX (2:1), and the substances alone. After time intervals of 2, 3, 7 and 15 days, the animals were euthanized and the specimens prepared for histological processing. Data were evaluated qualitatively according to the levels of tissue repair and the degree of inflammation.ResultOn the second day all the materials were observed to cause a severe inflammatory response. On the third day, the pastes Ca(OH)2+CHX+ZnO (2:1:2) and (2:1:3) showed reduction in degree of inflammation. On seventh day the tissue was already more organized with presence of collagen fibers in all materials. After 15 days it was found that compound Ca(OH)2+CHX+ZnO (2:1:2) showed areas with no inflammatory infiltrate.ConclusionThe experimental pastes, Ca(OH)2+CHX+ZnO in two different proportions (2:1:2) and (2:1:3), showed favorable results with respect to biocompatibility, when evaluated for a short-term. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772015000400232 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772015000400232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-2577.0079 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista Júlio de Mesquita Filho |
publisher.none.fl_str_mv |
Universidade Estadual Paulista Júlio de Mesquita Filho |
dc.source.none.fl_str_mv |
Revista de Odontologia da UNESP v.44 n.4 2015 reponame:Revista de Odontologia da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Revista de Odontologia da UNESP |
collection |
Revista de Odontologia da UNESP |
repository.name.fl_str_mv |
Revista de Odontologia da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||adriana@foar.unesp.br |
_version_ |
1748958559002951680 |