The influence of early bisphosphonate treatment on craniofacial radiographic bone density

• Autor(a) principal: Araujo, Melissa Rodrigues
• Data de Publicação: 2019
• Outros Autores: Mobile, Rafael Zancan, Azevedo, Lucas de Oliveira, Gomes, Shaiene, Deliberador, Tatiana Miranda, Giovanini, Allan Fernando
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Dental Science
• Texto Completo: https://ojs.ict.unesp.br/index.php/cob/article/view/1747

Objective: To evaluate the effects of alendronate (AL), a bisphosphonate, on visual bone density by means of a radiographic analysis. Material and methods: Sixty-two Wistar rats were divided into four groups: Group AA (AL with autogenous graft); group AW (AL without autogenous graft) both receiving AL on alternate days for 4 weeks before surgery; control group CA (with autogenous graft); group CW (without autogenous graft) both receiving saline solution before surgery. Experimental periods of evaluation were 2 weeks and 4 weeks post-surgery. Conventional and digital radiographs were obtained, and a 5-point grading system (score) was used to assess visual radiographic bone density. Results: There were no statistical differences between CA and AA groups at 2 and 4 weeks. The AA group had a higher mean score of bone density than the CW and AW groups at 2 weeks (P < 0.05). The CA and AA groups had higher scores of bone density than the CW and AW groups at 4 weeks (P < 0.05). Conclusions: Treatment with AL did not affect radiographic bone density at 2 and 4 weeks after surgery. The presence of an autograft resulted in higher scores of bone density.