Effectiveness of three different local routes of dexamethasone administration on postoperative sequelae following mandibular third molar surgery. A prospective randomised single-blind clinical study

• Autor(a) principal: Mosleh, Mohamed Ihab
• Data de Publicação: 2022
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Dental Science
• Texto Completo: https://ojs.ict.unesp.br/index.php/cob/article/view/2719

Objective: The aim of this study was to provide evidence for comparing the effectiveness of three different routesof local administration of Dexamethasone on the postoperative pain, edema and trismus following surgical removalof impacted mandibular third molar. Material and Methods: Forty-five patients underwent surgical removal ofimpacted lower third molars and were randomly allocated postoperatively into 3 groups: 8 mg of dexamethasoneinjected into the submucosa of the vestibule near the surgical site (group I), 8 mg of dexamethasone injected intothe pterygomandibular space (group II) and 10 mg of dexamethasone powder applied to the extraction site, afterbleeding control (group III). Facial swelling and maximal interincisal opening were measured at preoperatively.Pain was measured by the patient response to a visual analogue scale. Pain perception, Facial edema and trismuswere evaluated for one week postoperatively. Results: There was no significant difference between the threegroups concerning pain after 1, 2, 5, 7 days of follow up. However, group II showed less pain at 3 and 4 days.The difference between edema measurements was not significant in the three groups at 1, 5, 7 days, though ingroup I and II edema subsided from day 2. As for trismus, group I and III showed statistically significant lowermaximum interincisal opening measurement than group II after two days. Conclusion: Local administrationof Dexamethasone through three different routes is beneficial in decreasing postoperative sequelae followingthird molar surgery. Pterygomandibular space injection of Dexamethasone resulted in earlier resolution of pain,and less facial edema and trismus at the second postoperative day compared to the submucosal injection andtransalveolar application. However, at one week the difference in measurements of the three variables betweenthe groups was not significant.KEYWORDSDexamethasone; Local routes of administration; Mandibular third molar; Surgery.