Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Science |
Texto Completo: | https://ojs.ict.unesp.br/index.php/cob/article/view/1837 |
Resumo: | Objective: Recurrent aphthous stomatitis (RAS) is characterized by recurring ulcers, with well-defined margins. The lesions are confined to the oral mucosa (usually seen in non-keratinized mucosa). The disease manifests in the form of outbreaks, with a chronic and self-limiting course in most cases. Since the cause of the disease is unknown, many drugs have been studied to palliate the symptoms. Treatment used is multifocal and varies according to the predisposing factors. The aim of this study was to investigate the effect of recombinant Nano-based triamcinolone acetonide gel and compare it with conventional triamcinolone gel on RAS. Material and methods: In this triple-blind randomized clinical trial study, sixty patients with minor aphthous lesions were divided into two groups receiving conventional triamcinolone (CT) and Nano-based triamcinolone (NT). The patients were requested to apply drug four times a day for a week. The severity of pain (through VAS) and the size of the lesions (mean of the largest diameter of the lesions) were evaluated on starting day and days 2, 4, 6 after the intervention. Statistical analysis was performed using chi square and independent t-test. Findings were significant with P < 0.05. Findings: Of the 60 patients enrolled in the study, 5 patients did not continue; 21 (38.2%) cases were female and 34 (61.8%) cases were male (P=0.6). The severity of pain in NT group before and after the study was 1.4 ± 5.2 and 1.8 ± 1.3 cm, respectively and in CT group was 48.1 ± 1 and 1.8 ± 1.3 cm. The size of the lesions in NT group before and at the end of the study was 0.96 ± 0.1 and 0.18 ± 0.1 cm, respectively and in CT group was 0.93 ± 0.1 and 0.19 ± 0.1 cm. Among the mentioned variables, only size of lesions on the 2nd and 4th days had a significant reduction in NT group in comparison with CT group. Conclusion: The size of lesions showed a significant reduction on the 2nd and 4th days in NT group in comparison with CT group, therefore NT has a better impact on RAS in comparison with CT.KEYWORDSNanoparticle; Recurrent aphthous stomatitis; Treatment; Triamcinolone. |
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Brazilian Dental Science |
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Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitisObjective: Recurrent aphthous stomatitis (RAS) is characterized by recurring ulcers, with well-defined margins. The lesions are confined to the oral mucosa (usually seen in non-keratinized mucosa). The disease manifests in the form of outbreaks, with a chronic and self-limiting course in most cases. Since the cause of the disease is unknown, many drugs have been studied to palliate the symptoms. Treatment used is multifocal and varies according to the predisposing factors. The aim of this study was to investigate the effect of recombinant Nano-based triamcinolone acetonide gel and compare it with conventional triamcinolone gel on RAS. Material and methods: In this triple-blind randomized clinical trial study, sixty patients with minor aphthous lesions were divided into two groups receiving conventional triamcinolone (CT) and Nano-based triamcinolone (NT). The patients were requested to apply drug four times a day for a week. The severity of pain (through VAS) and the size of the lesions (mean of the largest diameter of the lesions) were evaluated on starting day and days 2, 4, 6 after the intervention. Statistical analysis was performed using chi square and independent t-test. Findings were significant with P < 0.05. Findings: Of the 60 patients enrolled in the study, 5 patients did not continue; 21 (38.2%) cases were female and 34 (61.8%) cases were male (P=0.6). The severity of pain in NT group before and after the study was 1.4 ± 5.2 and 1.8 ± 1.3 cm, respectively and in CT group was 48.1 ± 1 and 1.8 ± 1.3 cm. The size of the lesions in NT group before and at the end of the study was 0.96 ± 0.1 and 0.18 ± 0.1 cm, respectively and in CT group was 0.93 ± 0.1 and 0.19 ± 0.1 cm. Among the mentioned variables, only size of lesions on the 2nd and 4th days had a significant reduction in NT group in comparison with CT group. Conclusion: The size of lesions showed a significant reduction on the 2nd and 4th days in NT group in comparison with CT group, therefore NT has a better impact on RAS in comparison with CT.KEYWORDSNanoparticle; Recurrent aphthous stomatitis; Treatment; Triamcinolone.Institute of Science and Technology of São José dos Campos2019-10-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfimage/jpegapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://ojs.ict.unesp.br/index.php/cob/article/view/183710.14295/bds.2019.v22i4.1837Brazilian Dental Science; Vol. 22 No. 4 (2019): Oct. - Dec. / 2019 - Published October 2019; 554-560Brazilian Dental Science; v. 22 n. 4 (2019): Oct. - Dec. / 2019 - Published October 2019; 554-5602178-6011reponame:Brazilian Dental Scienceinstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESPenghttps://ojs.ict.unesp.br/index.php/cob/article/view/1837/1421https://ojs.ict.unesp.br/index.php/cob/article/view/1837/3852https://ojs.ict.unesp.br/index.php/cob/article/view/1837/3853Copyright (c) 2019 Brazilian Dental Scienceinfo:eu-repo/semantics/openAccessMirzaee, ShahlaGolestannejad, ZahraSadeghian, RastinRohani, BitaSadeghian, Saeid2020-01-23T17:39:02Zoai:ojs.pkp.sfu.ca:article/1837Revistahttp://bds.ict.unesp.br/PUBhttp://ojs.fosjc.unesp.br/index.php/index/oaisergio@fosjc.unesp.br||sergio@fosjc.unesp.br2178-60112178-6011opendoar:2022-11-08T16:30:25.129906Brazilian Dental Science - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)true |
dc.title.none.fl_str_mv |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
title |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
spellingShingle |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis Mirzaee, Shahla |
title_short |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
title_full |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
title_fullStr |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
title_full_unstemmed |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
title_sort |
Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis |
author |
Mirzaee, Shahla |
author_facet |
Mirzaee, Shahla Golestannejad, Zahra Sadeghian, Rastin Rohani, Bita Sadeghian, Saeid |
author_role |
author |
author2 |
Golestannejad, Zahra Sadeghian, Rastin Rohani, Bita Sadeghian, Saeid |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mirzaee, Shahla Golestannejad, Zahra Sadeghian, Rastin Rohani, Bita Sadeghian, Saeid |
description |
Objective: Recurrent aphthous stomatitis (RAS) is characterized by recurring ulcers, with well-defined margins. The lesions are confined to the oral mucosa (usually seen in non-keratinized mucosa). The disease manifests in the form of outbreaks, with a chronic and self-limiting course in most cases. Since the cause of the disease is unknown, many drugs have been studied to palliate the symptoms. Treatment used is multifocal and varies according to the predisposing factors. The aim of this study was to investigate the effect of recombinant Nano-based triamcinolone acetonide gel and compare it with conventional triamcinolone gel on RAS. Material and methods: In this triple-blind randomized clinical trial study, sixty patients with minor aphthous lesions were divided into two groups receiving conventional triamcinolone (CT) and Nano-based triamcinolone (NT). The patients were requested to apply drug four times a day for a week. The severity of pain (through VAS) and the size of the lesions (mean of the largest diameter of the lesions) were evaluated on starting day and days 2, 4, 6 after the intervention. Statistical analysis was performed using chi square and independent t-test. Findings were significant with P < 0.05. Findings: Of the 60 patients enrolled in the study, 5 patients did not continue; 21 (38.2%) cases were female and 34 (61.8%) cases were male (P=0.6). The severity of pain in NT group before and after the study was 1.4 ± 5.2 and 1.8 ± 1.3 cm, respectively and in CT group was 48.1 ± 1 and 1.8 ± 1.3 cm. The size of the lesions in NT group before and at the end of the study was 0.96 ± 0.1 and 0.18 ± 0.1 cm, respectively and in CT group was 0.93 ± 0.1 and 0.19 ± 0.1 cm. Among the mentioned variables, only size of lesions on the 2nd and 4th days had a significant reduction in NT group in comparison with CT group. Conclusion: The size of lesions showed a significant reduction on the 2nd and 4th days in NT group in comparison with CT group, therefore NT has a better impact on RAS in comparison with CT.KEYWORDSNanoparticle; Recurrent aphthous stomatitis; Treatment; Triamcinolone. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.ict.unesp.br/index.php/cob/article/view/1837 10.14295/bds.2019.v22i4.1837 |
url |
https://ojs.ict.unesp.br/index.php/cob/article/view/1837 |
identifier_str_mv |
10.14295/bds.2019.v22i4.1837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.ict.unesp.br/index.php/cob/article/view/1837/1421 https://ojs.ict.unesp.br/index.php/cob/article/view/1837/3852 https://ojs.ict.unesp.br/index.php/cob/article/view/1837/3853 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Dental Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Dental Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf image/jpeg application/vnd.openxmlformats-officedocument.wordprocessingml.document |
dc.publisher.none.fl_str_mv |
Institute of Science and Technology of São José dos Campos |
publisher.none.fl_str_mv |
Institute of Science and Technology of São José dos Campos |
dc.source.none.fl_str_mv |
Brazilian Dental Science; Vol. 22 No. 4 (2019): Oct. - Dec. / 2019 - Published October 2019; 554-560 Brazilian Dental Science; v. 22 n. 4 (2019): Oct. - Dec. / 2019 - Published October 2019; 554-560 2178-6011 reponame:Brazilian Dental Science instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Brazilian Dental Science |
collection |
Brazilian Dental Science |
repository.name.fl_str_mv |
Brazilian Dental Science - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
repository.mail.fl_str_mv |
sergio@fosjc.unesp.br||sergio@fosjc.unesp.br |
_version_ |
1788346901171535872 |