Conductometric determination of propranolol hydrochloride in pharmaceuticals

Detalhes bibliográficos
Autor(a) principal: Sartori,Elen Romão
Data de Publicação: 2011
Outros Autores: Barbosa,Nathália Vieira, Faria,Ronaldo Censi, Fatibello-Filho,Orlando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100008
Resumo: In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.
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spelling Conductometric determination of propranolol hydrochloride in pharmaceuticalsConductometric titrationpropranolol hydrochloridesilver nitratepharmaceutical formulationsIn this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100008Eclética Química v.36 n.1 2011reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702011000100008info:eu-repo/semantics/openAccessSartori,Elen RomãoBarbosa,Nathália VieiraFaria,Ronaldo CensiFatibello-Filho,Orlandoeng2012-02-29T00:00:00Zoai:scielo:S0100-46702011000100008Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2012-02-29T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Conductometric determination of propranolol hydrochloride in pharmaceuticals
title Conductometric determination of propranolol hydrochloride in pharmaceuticals
spellingShingle Conductometric determination of propranolol hydrochloride in pharmaceuticals
Sartori,Elen Romão
Conductometric titration
propranolol hydrochloride
silver nitrate
pharmaceutical formulations
title_short Conductometric determination of propranolol hydrochloride in pharmaceuticals
title_full Conductometric determination of propranolol hydrochloride in pharmaceuticals
title_fullStr Conductometric determination of propranolol hydrochloride in pharmaceuticals
title_full_unstemmed Conductometric determination of propranolol hydrochloride in pharmaceuticals
title_sort Conductometric determination of propranolol hydrochloride in pharmaceuticals
author Sartori,Elen Romão
author_facet Sartori,Elen Romão
Barbosa,Nathália Vieira
Faria,Ronaldo Censi
Fatibello-Filho,Orlando
author_role author
author2 Barbosa,Nathália Vieira
Faria,Ronaldo Censi
Fatibello-Filho,Orlando
author2_role author
author
author
dc.contributor.author.fl_str_mv Sartori,Elen Romão
Barbosa,Nathália Vieira
Faria,Ronaldo Censi
Fatibello-Filho,Orlando
dc.subject.por.fl_str_mv Conductometric titration
propranolol hydrochloride
silver nitrate
pharmaceutical formulations
topic Conductometric titration
propranolol hydrochloride
silver nitrate
pharmaceutical formulations
description In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702011000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702011000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.36 n.1 2011
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
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