New reagents for the spectrophotometric determination of ranitidine hydrochloride

Detalhes bibliográficos
Autor(a) principal: Narayana,B
Data de Publicação: 2010
Outros Autores: Veena,K, Ashwani,K, Shetty,Divya. N
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702010000300010
Resumo: A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer's law is obeyed in the concentration range of 0.4-8.0 µg/ ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6µg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell's sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.
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spelling New reagents for the spectrophotometric determination of ranitidine hydrochlorideSpectrophotometryRanitidine hydrochlorideCeric ammonium sulphateMalachite greenCrystal violetA new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer's law is obeyed in the concentration range of 0.4-8.0 µg/ ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6µg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell's sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2010-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702010000300010Eclética Química v.35 n.3 2010reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702010000300010info:eu-repo/semantics/openAccessNarayana,BVeena,KAshwani,KShetty,Divya. Neng2010-12-09T00:00:00Zoai:scielo:S0100-46702010000300010Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2010-12-09T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv New reagents for the spectrophotometric determination of ranitidine hydrochloride
title New reagents for the spectrophotometric determination of ranitidine hydrochloride
spellingShingle New reagents for the spectrophotometric determination of ranitidine hydrochloride
Narayana,B
Spectrophotometry
Ranitidine hydrochloride
Ceric ammonium sulphate
Malachite green
Crystal violet
title_short New reagents for the spectrophotometric determination of ranitidine hydrochloride
title_full New reagents for the spectrophotometric determination of ranitidine hydrochloride
title_fullStr New reagents for the spectrophotometric determination of ranitidine hydrochloride
title_full_unstemmed New reagents for the spectrophotometric determination of ranitidine hydrochloride
title_sort New reagents for the spectrophotometric determination of ranitidine hydrochloride
author Narayana,B
author_facet Narayana,B
Veena,K
Ashwani,K
Shetty,Divya. N
author_role author
author2 Veena,K
Ashwani,K
Shetty,Divya. N
author2_role author
author
author
dc.contributor.author.fl_str_mv Narayana,B
Veena,K
Ashwani,K
Shetty,Divya. N
dc.subject.por.fl_str_mv Spectrophotometry
Ranitidine hydrochloride
Ceric ammonium sulphate
Malachite green
Crystal violet
topic Spectrophotometry
Ranitidine hydrochloride
Ceric ammonium sulphate
Malachite green
Crystal violet
description A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer's law is obeyed in the concentration range of 0.4-8.0 µg/ ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6µg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell's sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.
publishDate 2010
dc.date.none.fl_str_mv 2010-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702010000300010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702010000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702010000300010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.35 n.3 2010
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
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