EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira Multidisciplinar |
Texto Completo: | http://revistarebram.com/index.php/revistauniara/article/view/764 |
Resumo: | The constant or repeated unprotected exposure to solar radiation can result in the onset of various harmful effects, such as inflammation, genetic mutation and hyperpigmentation, even than previous photoaging. The use of photoprotective formulations is one of the most effective tools to avoid this. However, most of the UV filters are unstable to UV radiation, can even permeate the skin and cause hepatotoxic effects. The aim of this study was to assess the efficacy and safety of a innovative sunscreen substance (E) -4- (tert-butyl) -N '- ((E) -3- (4-methoxyphenyl) allylidene) benzhydrazide. Methodology: The sunscreen formulation containing the innovative substance was subjected to various stress conditions: 45±2° C, 5±2° C and exposure to sunlight. These samples were evaluated in relation to its rheology, pH, viscosity, density and SPF to determine its stability. The assessment of TBMAB release from the formulation was performed in Microette equipment. Hepatoma cells (HepG2) were used to determine the TBMAB cytotoxicity. Results and Discussion: In the stability study, no significant changes were observed in the formulation. The maximum concentration of TBMAB released from the formulation was 3.63 µg.cm-2. Also, it was evident the cytotoxic effect on the concentrations well above 3.63 µg.cm-2,displaying the safety of this substance, considering HepG2 cells. Conclusion: These results demonstrate that TBMAB is a suitable innovative substance to be used in suscreens, exhibiting stability, desired SPF value and safety, considering HepG2 cells. Thus, it could be a new alternative to prevent skin cancer. |
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EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB)Efficacy and safety of innovative sunscreen (e) -4- (tert-butyl) -n '- ((e) -3- (4-methoxyphenyl) allylidene) benzidrazida (TBMAB)skin cancercytotoxicityUV filterssunscreen.The constant or repeated unprotected exposure to solar radiation can result in the onset of various harmful effects, such as inflammation, genetic mutation and hyperpigmentation, even than previous photoaging. The use of photoprotective formulations is one of the most effective tools to avoid this. However, most of the UV filters are unstable to UV radiation, can even permeate the skin and cause hepatotoxic effects. The aim of this study was to assess the efficacy and safety of a innovative sunscreen substance (E) -4- (tert-butyl) -N '- ((E) -3- (4-methoxyphenyl) allylidene) benzhydrazide. Methodology: The sunscreen formulation containing the innovative substance was subjected to various stress conditions: 45±2° C, 5±2° C and exposure to sunlight. These samples were evaluated in relation to its rheology, pH, viscosity, density and SPF to determine its stability. The assessment of TBMAB release from the formulation was performed in Microette equipment. Hepatoma cells (HepG2) were used to determine the TBMAB cytotoxicity. Results and Discussion: In the stability study, no significant changes were observed in the formulation. The maximum concentration of TBMAB released from the formulation was 3.63 µg.cm-2. Also, it was evident the cytotoxic effect on the concentrations well above 3.63 µg.cm-2,displaying the safety of this substance, considering HepG2 cells. Conclusion: These results demonstrate that TBMAB is a suitable innovative substance to be used in suscreens, exhibiting stability, desired SPF value and safety, considering HepG2 cells. Thus, it could be a new alternative to prevent skin cancer. A exposição constante e/ou repetida e desprotegida à radiação solar pode resultar no aparecimento de vários efeitos nocivos, como inflamação, mutação genética e hiperpigmentação, mesmo que o fotoenvelhecimento. O uso de formulações fotoprotetoras é uma das ferramentas mais eficazes para evitar isso. No entanto, a maioria dos filtros UV é instável à radiação UV, pode até permear a pele e causar efeitos hepatotóxicos. O objetivo deste estudo foi avaliar a eficácia e a segurança de uma substância protetora solar inovadora (E) -4- (terc-butil) -N '- ((E) -3- (4-metoxifenil) alilideno) benzidrazida. Métodos: A formulação de filtro solar contendo a substância inovadora foi submetida a várias condições de estresse: 45 ± 2°C, 5 ± 2°C e exposição à luz solar. Essas amostras foram avaliadas em relação à sua reologia, pH, viscosidade, densidade e FPS para determinar sua estabilidade. A avaliação da liberação de TBMAB à partir da formulação foi realizada em equipamentos Microette. As células de hepatoma (HepG2) foram usadas para determinar a citotoxicidade do TBMAB. Resultados e Discussão: No estudo de estabilidade, não foram observadas alterações significativas na formulação. A concentração máxima de TBMAB liberada a partir da formulação foi de 3.63 µg.cm-2. Também ficou evidente o efeito citotóxico nas concentrações bem acima de 3.63 µg.cm-2, demonstrando a segurança dessa substância, considerando as células HepG2. Conclusão: Esses resultados demonstram que o TBMAB é uma substância inovadora adequada para ser usada na fotoproteção, exibindo estabilidade, valor desejado de SPF e segurança, considerando as células HepG2. Assim, poderia ser uma nova alternativa para prevenir o câncer de pele.Revista Brasileira Multidisciplinar - ReBraM2021-01-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistarebram.com/index.php/revistauniara/article/view/76410.25061/2527-2675/ReBraM/2021.v24i1.764Revista Brasileira Multidisciplinar - ReBraM; v. 24 n. 1 (2021): Janeiro-Abril; 22-322527-26751415-3580reponame:Revista Brasileira Multidisciplinarinstname:Universidade de Araraquara (UNIARA)instacron:UNIARAporhttp://revistarebram.com/index.php/revistauniara/article/view/764/677Copyright (c) 2021 Revista Brasileira Multidisciplinarhttps://creativecommons.org/licenses/by-nd/4.0info:eu-repo/semantics/openAccessReis Junior, Mauricio AlexandreSanta Rosa, Brunade Santana Reis, JulianaAntônio Corrêa, MarcosGaldorfini Chiari-Andréo, Brunados Santos, Jean LeandroBorges Isaac, Vera Lucia2021-06-29T20:04:08Zoai:ojs.revistarebram.com:article/764Revistahttp://revistarebram.com/index.php/revistauniaraPRIhttps://revistarebram.com/index.php/revistauniara/oairevistauniara@uniara.com||2527-26752527-2675opendoar:2021-06-29T20:04:08Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA)false |
dc.title.none.fl_str_mv |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) Efficacy and safety of innovative sunscreen (e) -4- (tert-butyl) -n '- ((e) -3- (4-methoxyphenyl) allylidene) benzidrazida (TBMAB) |
title |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
spellingShingle |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) Reis Junior, Mauricio Alexandre skin cancer cytotoxicity UV filters sunscreen. |
title_short |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
title_full |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
title_fullStr |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
title_full_unstemmed |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
title_sort |
EFFICACY AND SAFETY OF INNOVATIVE SUNSCREEN (E) -4- (TERT-BUTYL) -N '- ((E) -3- (4-METHOXYPHENYL) ALLYLIDENE) BENZIDRAZIDA (TBMAB) |
author |
Reis Junior, Mauricio Alexandre |
author_facet |
Reis Junior, Mauricio Alexandre Santa Rosa, Bruna de Santana Reis, Juliana Antônio Corrêa, Marcos Galdorfini Chiari-Andréo, Bruna dos Santos, Jean Leandro Borges Isaac, Vera Lucia |
author_role |
author |
author2 |
Santa Rosa, Bruna de Santana Reis, Juliana Antônio Corrêa, Marcos Galdorfini Chiari-Andréo, Bruna dos Santos, Jean Leandro Borges Isaac, Vera Lucia |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Reis Junior, Mauricio Alexandre Santa Rosa, Bruna de Santana Reis, Juliana Antônio Corrêa, Marcos Galdorfini Chiari-Andréo, Bruna dos Santos, Jean Leandro Borges Isaac, Vera Lucia |
dc.subject.por.fl_str_mv |
skin cancer cytotoxicity UV filters sunscreen. |
topic |
skin cancer cytotoxicity UV filters sunscreen. |
description |
The constant or repeated unprotected exposure to solar radiation can result in the onset of various harmful effects, such as inflammation, genetic mutation and hyperpigmentation, even than previous photoaging. The use of photoprotective formulations is one of the most effective tools to avoid this. However, most of the UV filters are unstable to UV radiation, can even permeate the skin and cause hepatotoxic effects. The aim of this study was to assess the efficacy and safety of a innovative sunscreen substance (E) -4- (tert-butyl) -N '- ((E) -3- (4-methoxyphenyl) allylidene) benzhydrazide. Methodology: The sunscreen formulation containing the innovative substance was subjected to various stress conditions: 45±2° C, 5±2° C and exposure to sunlight. These samples were evaluated in relation to its rheology, pH, viscosity, density and SPF to determine its stability. The assessment of TBMAB release from the formulation was performed in Microette equipment. Hepatoma cells (HepG2) were used to determine the TBMAB cytotoxicity. Results and Discussion: In the stability study, no significant changes were observed in the formulation. The maximum concentration of TBMAB released from the formulation was 3.63 µg.cm-2. Also, it was evident the cytotoxic effect on the concentrations well above 3.63 µg.cm-2,displaying the safety of this substance, considering HepG2 cells. Conclusion: These results demonstrate that TBMAB is a suitable innovative substance to be used in suscreens, exhibiting stability, desired SPF value and safety, considering HepG2 cells. Thus, it could be a new alternative to prevent skin cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/764 10.25061/2527-2675/ReBraM/2021.v24i1.764 |
url |
http://revistarebram.com/index.php/revistauniara/article/view/764 |
identifier_str_mv |
10.25061/2527-2675/ReBraM/2021.v24i1.764 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/764/677 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Brasileira Multidisciplinar https://creativecommons.org/licenses/by-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Brasileira Multidisciplinar https://creativecommons.org/licenses/by-nd/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
dc.source.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM; v. 24 n. 1 (2021): Janeiro-Abril; 22-32 2527-2675 1415-3580 reponame:Revista Brasileira Multidisciplinar instname:Universidade de Araraquara (UNIARA) instacron:UNIARA |
instname_str |
Universidade de Araraquara (UNIARA) |
instacron_str |
UNIARA |
institution |
UNIARA |
reponame_str |
Revista Brasileira Multidisciplinar |
collection |
Revista Brasileira Multidisciplinar |
repository.name.fl_str_mv |
Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA) |
repository.mail.fl_str_mv |
revistauniara@uniara.com|| |
_version_ |
1797174606777286656 |