Drugs and nonsyndromic orofacial cleft: an update

Detalhes bibliográficos
Autor(a) principal: Palmieri, Annalisa
Data de Publicação: 2016
Outros Autores: Avantaggiato, Anna, Arlotti, Giorgio Brunelli Marzia, Scapoli, Luca, Martinelli, Marcella, Pezzetti, Furio, Carinci, Francesco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian journal of oral sciences (Online)
Texto Completo: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941
Resumo: Nonsyndromic orofacial cleft (OFC) derives from an embryopathy with failure of the nasal processes and/or fusion of the palatal shelves. This severe birth defect is one of the most common malformations among live births. Human cleft is composed of two separate entities: cleft of the lip with or without palate (CL±P) and cleft palate only (CPO). Both have a genetic origin, whereas environmental factors contribute to these congenital malformations. In this review we analyze the role of drugs related to the onset of cleft. The data were obtained from (i) epidemiologic studies (ii) animal models and (iii) human genetic investigations. These studies have demonstrated a relation between certain drugs (steroids and anticonvulsants) taken during pregnancy and a higher risk of generating offspring with OFC whereas no clear relation has been demonstrated between aspirin and OFC.
id UNICAMP-8_900c8afc9dc51ca72fbcdd56f5294197
oai_identifier_str oai:ojs.periodicos.sbu.unicamp.br:article/8642941
network_acronym_str UNICAMP-8
network_name_str Brazilian journal of oral sciences (Online)
repository_id_str
spelling Drugs and nonsyndromic orofacial cleft: an updateCleftSteroidAnticonvulsivantCortisonePhenytoinOdontologyNonsyndromic orofacial cleft (OFC) derives from an embryopathy with failure of the nasal processes and/or fusion of the palatal shelves. This severe birth defect is one of the most common malformations among live births. Human cleft is composed of two separate entities: cleft of the lip with or without palate (CL±P) and cleft palate only (CPO). Both have a genetic origin, whereas environmental factors contribute to these congenital malformations. In this review we analyze the role of drugs related to the onset of cleft. The data were obtained from (i) epidemiologic studies (ii) animal models and (iii) human genetic investigations. These studies have demonstrated a relation between certain drugs (steroids and anticonvulsants) taken during pregnancy and a higher risk of generating offspring with OFC whereas no clear relation has been demonstrated between aspirin and OFC.Universidade Estadual de Campinas2016-09-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864294110.20396/bjos.v7i24.8642941Brazilian Journal of Oral Sciences; v. 7 n. 24 (2008): Jan./Mar; 1470-1475Brazilian Journal of Oral Sciences; Vol. 7 No. 24 (2008): Jan./Mar; 1470-14751677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941/10506https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941/10569Palmieri, AnnalisaAvantaggiato, AnnaArlotti, Giorgio Brunelli MarziaScapoli, LucaMartinelli, MarcellaPezzetti, FurioCarinci, Francescoinfo:eu-repo/semantics/openAccess2016-09-23T14:41:49Zoai:ojs.periodicos.sbu.unicamp.br:article/8642941Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-09-23T14:41:49Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv Drugs and nonsyndromic orofacial cleft: an update
title Drugs and nonsyndromic orofacial cleft: an update
spellingShingle Drugs and nonsyndromic orofacial cleft: an update
Palmieri, Annalisa
Cleft
Steroid
Anticonvulsivant
Cortisone
Phenytoin
Odontology
title_short Drugs and nonsyndromic orofacial cleft: an update
title_full Drugs and nonsyndromic orofacial cleft: an update
title_fullStr Drugs and nonsyndromic orofacial cleft: an update
title_full_unstemmed Drugs and nonsyndromic orofacial cleft: an update
title_sort Drugs and nonsyndromic orofacial cleft: an update
author Palmieri, Annalisa
author_facet Palmieri, Annalisa
Avantaggiato, Anna
Arlotti, Giorgio Brunelli Marzia
Scapoli, Luca
Martinelli, Marcella
Pezzetti, Furio
Carinci, Francesco
author_role author
author2 Avantaggiato, Anna
Arlotti, Giorgio Brunelli Marzia
Scapoli, Luca
Martinelli, Marcella
Pezzetti, Furio
Carinci, Francesco
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Palmieri, Annalisa
Avantaggiato, Anna
Arlotti, Giorgio Brunelli Marzia
Scapoli, Luca
Martinelli, Marcella
Pezzetti, Furio
Carinci, Francesco
dc.subject.por.fl_str_mv Cleft
Steroid
Anticonvulsivant
Cortisone
Phenytoin
Odontology
topic Cleft
Steroid
Anticonvulsivant
Cortisone
Phenytoin
Odontology
description Nonsyndromic orofacial cleft (OFC) derives from an embryopathy with failure of the nasal processes and/or fusion of the palatal shelves. This severe birth defect is one of the most common malformations among live births. Human cleft is composed of two separate entities: cleft of the lip with or without palate (CL±P) and cleft palate only (CPO). Both have a genetic origin, whereas environmental factors contribute to these congenital malformations. In this review we analyze the role of drugs related to the onset of cleft. The data were obtained from (i) epidemiologic studies (ii) animal models and (iii) human genetic investigations. These studies have demonstrated a relation between certain drugs (steroids and anticonvulsants) taken during pregnancy and a higher risk of generating offspring with OFC whereas no clear relation has been demonstrated between aspirin and OFC.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941
10.20396/bjos.v7i24.8642941
url https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941
identifier_str_mv 10.20396/bjos.v7i24.8642941
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941/10506
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642941/10569
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual de Campinas
publisher.none.fl_str_mv Universidade Estadual de Campinas
dc.source.none.fl_str_mv Brazilian Journal of Oral Sciences; v. 7 n. 24 (2008): Jan./Mar; 1470-1475
Brazilian Journal of Oral Sciences; Vol. 7 No. 24 (2008): Jan./Mar; 1470-1475
1677-3225
reponame:Brazilian journal of oral sciences (Online)
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Brazilian journal of oral sciences (Online)
collection Brazilian journal of oral sciences (Online)
repository.name.fl_str_mv Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv brjorals@fop.unicamp.br||brjorals@fop.unicamp.br
_version_ 1800216401132126208

Registros relacionados