Matrix metalloproteinases: the most important pathway involved with periodontal destruction

Detalhes bibliográficos
Autor(a) principal: De Souza, A.P
Data de Publicação: 2015
Outros Autores: Da Silva, R.A, Da Silva, M.A.D, Guimarães, Sérgio Augusto Catanzaro, Line, Sergio Roberto Peres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian journal of oral sciences (Online)
Texto Completo: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850
Resumo: Periodontitis is an infectious disease estimated to occur in approximately a third of adults over the age of 35, being the major cause of adult tooth loss. The tissue destruction seems to be regulated by four major pathways. Plasminogen-dependent, phagocytic, osteoclastic and matrix metalloproteinase pathway. The matrix metalloproteinases (MMPs) pathway seems to be the most relevant in periodontal disease. The purpose of the current study was to review the roles of MMPs on periodontal disease, with emphasis on periodontal ligament and alveolar bone destruction. Particular attention is given on the mechanisms that control MMPs genes transcription, the regulation of protein activity, and the influence of MMP genes polymorphisms in inflammatory diseases.
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spelling Matrix metalloproteinases: the most important pathway involved with periodontal destructionMMP. Cytokine. Periodontitis. Genes polymorphismsOdontologiaPeriodontitis is an infectious disease estimated to occur in approximately a third of adults over the age of 35, being the major cause of adult tooth loss. The tissue destruction seems to be regulated by four major pathways. Plasminogen-dependent, phagocytic, osteoclastic and matrix metalloproteinase pathway. The matrix metalloproteinases (MMPs) pathway seems to be the most relevant in periodontal disease. The purpose of the current study was to review the roles of MMPs on periodontal disease, with emphasis on periodontal ligament and alveolar bone destruction. Particular attention is given on the mechanisms that control MMPs genes transcription, the regulation of protein activity, and the influence of MMP genes polymorphisms in inflammatory diseases.Universidade Estadual de Campinas2015-11-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864185010.20396/bjos.v4i15.8641850Brazilian Journal of Oral Sciences; v. 4 n. 15 (2005): Oct./Dec; 884-890Brazilian Journal of Oral Sciences; Vol. 4 No. 15 (2005): Oct./Dec; 884-8901677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850/9349De Souza, A.PDa Silva, R.ADa Silva, M.A.DGuimarães, Sérgio Augusto CatanzaroLine, Sergio Roberto Peresinfo:eu-repo/semantics/openAccess2016-02-25T09:26:47Zoai:ojs.periodicos.sbu.unicamp.br:article/8641850Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-02-25T09:26:47Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv Matrix metalloproteinases: the most important pathway involved with periodontal destruction
title Matrix metalloproteinases: the most important pathway involved with periodontal destruction
spellingShingle Matrix metalloproteinases: the most important pathway involved with periodontal destruction
De Souza, A.P
MMP. Cytokine. Periodontitis. Genes polymorphisms
Odontologia
title_short Matrix metalloproteinases: the most important pathway involved with periodontal destruction
title_full Matrix metalloproteinases: the most important pathway involved with periodontal destruction
title_fullStr Matrix metalloproteinases: the most important pathway involved with periodontal destruction
title_full_unstemmed Matrix metalloproteinases: the most important pathway involved with periodontal destruction
title_sort Matrix metalloproteinases: the most important pathway involved with periodontal destruction
author De Souza, A.P
author_facet De Souza, A.P
Da Silva, R.A
Da Silva, M.A.D
Guimarães, Sérgio Augusto Catanzaro
Line, Sergio Roberto Peres
author_role author
author2 Da Silva, R.A
Da Silva, M.A.D
Guimarães, Sérgio Augusto Catanzaro
Line, Sergio Roberto Peres
author2_role author
author
author
author
dc.contributor.author.fl_str_mv De Souza, A.P
Da Silva, R.A
Da Silva, M.A.D
Guimarães, Sérgio Augusto Catanzaro
Line, Sergio Roberto Peres
dc.subject.por.fl_str_mv MMP. Cytokine. Periodontitis. Genes polymorphisms
Odontologia
topic MMP. Cytokine. Periodontitis. Genes polymorphisms
Odontologia
description Periodontitis is an infectious disease estimated to occur in approximately a third of adults over the age of 35, being the major cause of adult tooth loss. The tissue destruction seems to be regulated by four major pathways. Plasminogen-dependent, phagocytic, osteoclastic and matrix metalloproteinase pathway. The matrix metalloproteinases (MMPs) pathway seems to be the most relevant in periodontal disease. The purpose of the current study was to review the roles of MMPs on periodontal disease, with emphasis on periodontal ligament and alveolar bone destruction. Particular attention is given on the mechanisms that control MMPs genes transcription, the regulation of protein activity, and the influence of MMP genes polymorphisms in inflammatory diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850
10.20396/bjos.v4i15.8641850
url https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850
identifier_str_mv 10.20396/bjos.v4i15.8641850
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641850/9349
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Estadual de Campinas
publisher.none.fl_str_mv Universidade Estadual de Campinas
dc.source.none.fl_str_mv Brazilian Journal of Oral Sciences; v. 4 n. 15 (2005): Oct./Dec; 884-890
Brazilian Journal of Oral Sciences; Vol. 4 No. 15 (2005): Oct./Dec; 884-890
1677-3225
reponame:Brazilian journal of oral sciences (Online)
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Brazilian journal of oral sciences (Online)
collection Brazilian journal of oral sciences (Online)
repository.name.fl_str_mv Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv brjorals@fop.unicamp.br||brjorals@fop.unicamp.br
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