Mucosite oral decorrente do tratamento de câncer de mama
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| Data de Publicação: | 2020 |
| Outros Autores: | , |
| Tipo de documento: | Trabalho de conclusão de curso |
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| Título da fonte: | Repositório Institucional da Universidade Cruzeiro do Sul |
| Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/1377 |
Resumo: | A incidência global de câncer duplicou nos últimos 30 anos, sendo que nas mulheres, o câncer de mama é o tipo que mais acomete. Atualmente, os tratamentos mais utilizados para o câncer de mama incluem tratamento localizado com radioterapia, cirurgia com reconstrução mamária, quando necessário, quimioterapia, terapia biológica, e hormonioterapia. O tratamento quimioterápico pode apresentar complicações orais em cerca de 40% dos pacientes oncológicos. Este tratamento possui efeito citotóxico em diferentes tipos celulares, e desta forma dependendo da posologia e do tipo de quimioterápico utilizado uma série de efeitos adversos podem evoluir em graus leves a graves. A mucosite é uma complicação oral muito frequente nestes pacientes e apresenta-se como eritema, seguido de ulcerações dolorosas na mucosa bucal, que influenciam na capacidade de nutrição e na qualidade de vida dos pacientes, o que pode até limitar ou adiar o planejamento da terapia oncológica. |
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2021-01-26T18:15:55Z2021-01-262021-01-26T18:15:55Z2020https://repositorio.cruzeirodosul.edu.br/handle/123456789/1377A incidência global de câncer duplicou nos últimos 30 anos, sendo que nas mulheres, o câncer de mama é o tipo que mais acomete. Atualmente, os tratamentos mais utilizados para o câncer de mama incluem tratamento localizado com radioterapia, cirurgia com reconstrução mamária, quando necessário, quimioterapia, terapia biológica, e hormonioterapia. O tratamento quimioterápico pode apresentar complicações orais em cerca de 40% dos pacientes oncológicos. Este tratamento possui efeito citotóxico em diferentes tipos celulares, e desta forma dependendo da posologia e do tipo de quimioterápico utilizado uma série de efeitos adversos podem evoluir em graus leves a graves. A mucosite é uma complicação oral muito frequente nestes pacientes e apresenta-se como eritema, seguido de ulcerações dolorosas na mucosa bucal, que influenciam na capacidade de nutrição e na qualidade de vida dos pacientes, o que pode até limitar ou adiar o planejamento da terapia oncológica.A global cancer of cancer has doubled in the last 30 years, and in women, breast cancer is the type that most affects. Currently, the most used treatments for breast cancer include localized treatment with radiotherapy, surgery with breast reconstruction when necessary, chemotherapy, biological therapy and hormone therapy. Chemotherapy treatment can present oral complications in about 40% of cancer patients. This treatment has a cytotoxic effect on different cell types, and therefore depends on the dosage and the type of chemotherapy used. A series of adverse effects can evolve from mild to severe degrees. Mucositis is a very common oral complication in patient patients and presents as erythema, followed by painful ulcerations in the oral mucosa, which influence the nutritional capacity and quality of life of patients, which may even limit or delay therapy planning oncology. This paper aims to review the literature on oral mucositis resulting frporCentro de Ensino Unificado do Distrito FederalUDFBrasilCoordenação do Curso de Odontologia4.02.00.00-0 OdontologiaNeoplasia da mamaEstomatiteTerapia farmacológicaMucosite oral decorrente do tratamento de câncer de mamainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisPavan, Ludmila Madeira Cardosohttp://lattes.cnpq.br/1000030122409051...Pascoal, Daniela da SilvaCarvalho, Elda Lorrane BarrosSousa, Samara Agatha Augusto de1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. 2. Taichman L. Oral Health-Related Complications of Breast Cancer Treatment: Assessing Dental Hygienists' Knowledge and Professional Practice. Journal of dental hygiene: JDH vol. 89 Suppl 2,Suppl 2 (2015): 22-37. 3. Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. – Rio de Janeiro: INCA, 2019. Disponível em:<www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020- incidencia-de-cancer-no-brasil.pdf> 4. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941-53. 5. INCA. Instituto Nacional do Câncer: Estadiamento. 2019. Disponível em: <www.inca.gov.br/estadiamento>. 6. Brasil. Portaria conjunta Nª 19, de 3 de Julho de 2018. Diretrizes Diagnósticas e Terapêuticas – Carcinoma de Mama. Ministério da saúde. De Julho de 2018. Disponível em: www.saude.gov.br/images/pdf/2018/julho/16/Portaria-Conjunta-n-19-- PCDT-Carcinoma-de-Mama.pdf 7. Marinho, PML. Mucosite oral por quimioterapia e qualidade de vida relacionada a saúde de mulheres com câncer de mama, Tese de doutorado: Ribeirão preto. Escola de enfermagem de Ribeirão Preto da Universidade de São Paulo;2020. 8. INCA. Instituto Nacional do Câncer: Como se comportam as células cancerosas. 2020. Disponível em: <www.inca.gov.br/como-se-comportam-celulascancerosas>. 9. INCA. Instituto Nacional do Câncer: Como surge o câncer. 2019. Disponível em: <www1.inca.gov.br/impressao.asp?op=cv&id=319>. 10. INCA. Instituto Nacional do Câncer: Câncer de mama. 2020. Disponível em: <www.inca.gov.br/tipos-de-cancer/cancer-de-mama>. 11. American cancer society. Cancer facts & figures 2019. Atlanta: American Cancer Society, 2019ª. Disponível em: www.cancer.org/content/dam/cancerorg/ research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breastcancer- facts-and-figures-2019-2020.pdf 12. Shao J, Wu L, Leng WD, Fang C, Zhu YJ, Jin YH. Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants. Front. Oncol. 2018; 8:601. 30 13. Sfreddo CS, Maier J, De David SC, Susin C, Moreira CHC. Periodontitis and breast cancer: A case-control study. Community Dent Oral Epidemiol. 2017 Dec;45(6):545-551. doi: 10.1111/cdoe.12318. 14. Kumar, S. Principles of cancer treatment by immunotherapy. Surgery, [s. l.],v. 30, n. 4, p. 198-202, 2012. DOI 10.1016/j.mpsur.2012.01.009. 15. Kakimi K, Karasaki T, Matsushita H, Sugie T. Advances in personalized cancer immunotherapy. Breast Cancer. 2017 Jan;24(1):16-24. 16. INCA. Instituto Nacional do Câncer: Tratamento do câncer. Quimioterapia. 2018. Disponível em: www.inca.gov.br/tratamento/quimioterapia 17. Caldeira MB, Galbiatti-Dias SLA. Acompanhamento e avaliação dos efeitos adversos da quimioterapia em pacientes com câncer de mama. 2017. 2p. União das Faculdades dos Grandes Lagos, sp. 18. Curra, M. Chemotherapy protocols and incidence of oral mucositis: an integrative review. Revista Einstein, v. 16, n. 1, p. 1-9, 2018. 19. Goyri, BLM.; Ramos, MEC.; Pérez, EE. Chemotherapy-induced oral stomatotoxicity. Revista Odontológica Mexicana, v. 18, n. 2, p. 89–95, 2014. 20. INCA. Diretrizes para a detecção precoce do câncer de mama no Brasil. 1. ed. INCA, 2015. 168p. Disponível em: www.inca.gov.br/publicacoes/livros/diretrizespara- deteccao-precoce-do-cancer-de-mama-no-brasil 21. Patussi C, Sassi ML, Munhoz CE, Zanicotti STR, Schussel LJ. A avaliação clínica da mucosite oral e candidíase é comparada ao nadir quimioterápico em pacientes transplantados. Braz. oral res. [online]. 2014. 22. Marinho PML. Mucosite oral por quimioterapia e qualidade de vida relacionada à saúde de mulheres com câncer de mama [tese]. Ribeirão Preto: , Escola de Enfermagem de Ribeirão Preto; 2020. 23. Sasada INV, Munerato MC, Gregianin LJ. Mucosite oral em crianças com câncer – [Revisão de literatura]. RFO, Passo Fundo. 2013;18(3):345-50. 24. Araújo, SNM. Cancer patients with oral mucositis: challenges for nursing care. Revista Latino-Americana de Enfermagem [online], v. 23, n. 2, p. 267–274, 2015b 25. Goyri, BLM.; Ramos, MEC.; Pérez, EE. Chemotherapy-induced oral stomatotoxicity. Revista Odontológica Mexicana, v. 18, n. 2, p. 89–95, 2014. 26. Morais, JR. Characterization of the patient with chemotherapy-induced oral mucositis. Revista de Enfermagem da UFPI, v. 4, n. 1, p. 26–32, 2015. 27. Musso MAA. Associação das Manifestações Bucais com Variáveis Sociodemográficas e Clínicas em Mulheres com Câncer de Mama. Revista Brasileira de Ciências da Saúde, v. 22, n. 3, p. 203-212, 2018. 31 28. Petersson, DE. Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice. Cancer Medicine, v. 5, n. 8, p. 1897-1907, 2016. 29. Seiler S. Adverse event management of oral mucositis in patients with breast cancer. Breast Care, v. 9, n. 4, p. 232–237, 2014. 30. Volpato LER.; Silva TC.; Oliveira TM; Sakai, VT; Machado MAAM. Mucosite bucal rádio e quimioinduzida. Revista brasileira de otorrinolaringologia., São Paulo, v.73, n.4, Ago. 2007. 31. Rampini MP, Ferreira EMS, Ferreira CG, Antunes HS. Utilização da terapia com laser de baixa potencias para prevenção de mucosite oral: revisão de literatura. Revista Brasileira de Cancerologia.2009;55(1): 59-68. 32. Katranci N. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - A randomized controlled trial. European Journal of Oncology Nursing, v.16, p. 339-44, 2012. 33. Fligiola SLC. Fatores de risco para mucosite bucal em pacientes com leucemia linfóide aguda submetidos a diferentes protocolos de tratamento [tese]. Bauru (SP): Universidade de São Paulo; 2007. 34. Sonis ST. Pathobiology of oral mucositis: novel insights and opportunities. Supportive Oncology, v. 5, n.9, p. 3-11, 2007. 35. Cuba LF, Salum F, Cherubini K, Figueiredo MAZ. Antioxidant agents: A future alternative approach in the prevention and treatment of radiation-induced oral mucositis? Altern Ther Health Med. 2015;21(2):36-41. 36. Sonis ST. A biological approach to mucositis. J Supportive Oncology. 2004;2(1):21-32; discussion 35-6. 37. Cidon U. Chemotherapy induced oral mucositis: prevention is possible. Medical Oncology. 2017; 1-7. 38. Marín-Conde F, Castellanos-Cosano L., Pachón-Ibañez J, Serrera-Figallo MA., Gutiérrez-Pérez JL.,Torres-Lagares D. Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial. International Journal of Oral and Maxillofacial. 2018. 39. World Health Organization. (1979). WHO handbook for reporting results of cancer treatment. World Health Organization. Disponível em:<https://apps.who.int/iris/handle/10665/37200> 40. Abdel Moneim AE, Guerra-Librero A., Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D, Escames G. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int J Mol Sci. 2017 May 7;18(5):1003. 32 41. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014 May; 120(10):1453-61. 42. Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dent Clin North Am. 2008 Jan; 52(1):61-77. 43. Lalla RV, Saunders DP, Peterson DE. Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am. 2014 Apr; 58(2):341-9. 44. Brito CA, Araújo DS, Granja JG, Souza SM, Lima MAG, Oliveira MC. Efeito da clorexidina e do laser de baixa potência na prevenção e no tratamento da mucosite oral. Rev Odontol UNESP. 2012 Jul-Ago; 41(4):236-41. 45. Campos MIDC, Campos CN, Aarestrup FM, Aarestrup BJV. Oral mucositis in cancer treatment: Natural history, prevention and treatment. Mol Clin Oncol. 2014;2(3):337–40. 46. Mallick S, Benson, Rath GK. Radiation induced oral mucositis: a review of current literature on prevention and management. Eur Arch Otorhinolaryngol. 2015. 47. Henke M, Alfonsi M, Foa P, Giralt J, Bardet E, Cerezo L, Salzwimmer M, Lizambri R, Emmerson L, Chen MG, Berger D. Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trial. J Clin Oncol. 2011;9(20):2815–2820. 48. Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH. Effects of honey on oral mucositis in patients with head and neck cancer: A meta analysis. Laryngoscope. 2015; 125: 2085-2092. 49. Hawley P, Hovan A, McGahan CE, Saunders D. A randomized placebocontrolled trial of manuka honey for radiation – induced oral mucositis. Support Care Cancer. 2014; 22: 751-761. 50. Raeessi MA, Raeessi N, Panahi Y, Gharaie H, Davoudi SM, Saadat A, Zarchi AAK, Raeessi F, Ahmadi SM, Jalalian H. “Coffee plus honey” versus “topical steroid” in the treatment of chemotherapy-induced oral mucositis: a randomized controlled trial. BMC Complement Altern Med. 2014; 14:293. 51. Urbain P. Role of antioxidants in buccal mucosa cells and plasma on the incidence and severity of oral mucositis after allogeneic haematopoietic cell transplantation. Supportive Care in Cancer, v. 20, p. 1831–1838, 2012. 52. Santos, SB. O efeito da vitamina E e do selênio na prevenção da mucosite em pacientes com tumores malignos nas vias aerodigestivas superiores submetidos a radioterapia, concomitantemente ou não com quimioterapia [dissertação]. São Paulo: Universidade de São Paulo, Faculdade de Medicina; 2009. 53. Lederer, J. 1990. Alimentação e câncer. 3a edição. Editora Malone Dois, São Paulo. 33 54. Oveissi V, Ram M, Bahramsoltani R. Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective. Daru; 2019. 55. Chandrashekhar VM, Ranpariya VL, Ganapaty S. Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats. J Ethnopharmacol. 2010; 127(3):645–51 56. Salehi B, Lopez-Jornet P, Pons-Fuster López E, Calina D, Sharifi-Rad M, Ramírez-Alarcón K, Forman K, Fernández M, Martorell M, Setzer WN, Martins N, Rodrigues CF, Sharifi-Rad J. Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. Biomolecules. 2019 Mar 17;9(3):106. 57. Miranda P.M, Souza S.D. Glutamina na Prevenção e Tratamento da Mucosite em Pacientes Adultos Oncológicos: uma Revisão Sistemática da Literatura. Revista Brasileira de Cancerologia 2015; 61(3): 277-285. 58. Peterson DE, Jones JB, Petit RG. Randomized, Placebo controlled trial of saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy. Cancer. 2007;109(2):322-31 59. Centurion BS; Garcias AS; Rubira-Bullen IRF; Santos PSS. Avaliação clínica e tratamento das complicações bucais pós quimioterapia e radioterapia., 66, 2, pp. 136-141. ISSN 0004-5276. 60. Rubenstein EB. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer, New York, v.100, n.9, p.2026-2046, May 2004. 61. Guimarães JJ. Tratamento das manifestações estomatológicas antes, no decorrer e depois de quimio e radioterapia. In: MARCUCCI, G. Fundamentos de odontologia: estomatologia. Rio de Janeiro: Guanabara Koogan, 2005. p.205-212. 62. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 2007;109:820–31 63. Cerchietti L. Morphine mouthwashes for painful mucositis. Support Care Cancer. 2007;15:115–6 64. Vayne-Bossert P, Escher M, de Vautibault CG, Dulguerov P, Allal A, Desmeules J, et al. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: A randomized double-blinded study. J Palliat Med. 2010;13:125–8. 65. Charbaji N, Schäfer-Korting M, Küchler S. Morphine stimulates cell migration of oral epithelial cells by delta-opioid receptor activation. PLoS One. 2012;7:e42616. 34 66. Xing SZ, Zhang Y. Efficacy and safety of transdermal fentanyl for the teratment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma. Support Care Cancer. 2015 Mar; 23(3):753-9. 67. Oberoi S., Zamperlini-Netto G., Beyene J., Treister NS, Sung L. Low-level laser therapy and laser debridement for management of oral mucositis in patients with head and neck cancer receiving chemotherapy and radiation. PLoS ONE. 2014; 9 : e107418. doi: 10.1371 / journal.pone.0107418 68. Alvarino-Martin C., Sarrion-Perez MG. Prevention and treatment of oral mucositis in patients receiving chemotherapy J. Clin. Exp. Dente. 2014; 6 : e74 – e80. doi: 10.4317 / jced.51313. 69. Allan E., Barney C., Baum S., Kessling T., Diavolitsis VM, Blakaj D., Grecula JC, Rocco JW, van Putten M., Bhatt AD. Low-level laser therapy and laser debridement for management of oral mucositis in patients with head and neck cancer receiving chemotherapy and radiation. Int. J. Radiat. Oncol. Biol. Phys. 2016; 94 : 883. doi: 10.1016 / j.ijrobp.2015.12.066. 70. Spezzia S. Mucosite oral. J Oral Invest, 4(1): 14-18, 2015 - ISSN 2238-510X 71. Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol,1998; 34(1): 39- 43. 72. Brugnera JA. Atlas de laserterapia aplicada à clínica odontológica. 1a. ed. São Paulo: Ed. Santos, 2003. 73. Hespanhol FL, Tinoco BEM, Teixeira HGC, Falabella MEV, Assis NMSP. Manifestações bucais em pacientes submetidos à quimioterapia. Ciênc Saúde Coletiva 2010;15(Supl 1):1085-94. 74. Amadori F, Bardellini E, Conti G, Pedrini N, Schumacher RF, Majorana A. Low-level laser therapy for treatment of chemotherapy- induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers Med Sci. 2016;31;(6):1231-6. 75. Cruz LB, Ribeiro AS, Rech A, Rosa LGN, Castro CG Jr, Bruneto AL. Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy. Pediatr Blood Cancer. 2007;48(4):435-40. 76. Kashiwazaki H ; Matsushita T ; Sugita J; Shigematsu A ; Kasashi K ; Yamazaki Y ; Kanehira T ; Yamamoto S ; Kondo T ; Endo T. Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer. 2012 Feb;20(2):367-73. doi: 10.1007/s00520-011-1116-x. 77. Yokota T; Tachibana H; Konishi T ; Yurikusa T ; Hamauchi, S; Sakai K; Nishikawa M; Suzuki M; Naganawa Y; Hagihara T. Multicenter phase II study of an oral care program for patients with head and neck cancer receiving 35 chemoradiotherapy. Support Care Cancer. 2016 Jul;24(7):3029-36. doi: 10.1007/s00520-016-3122-5. 78. Bradstock, KF; Link, E .; Collins, M .; Di Iulio, J .; Lewis, ID; Schwarer, A .; Enno, A .; Marlton, P .; Hahn, U .; Szer, J. A randomized trial of prophylactic palifermin on gastrointestinal toxicity after intensive induction therapy for acute myeloid leukaemia. Br J Haematol. 2014 Dec;167(5):618-25. doi: 10.1111/bjh.13086. 79. Blijlevens N, de Château M, Krivan G, Rabitsch W, Szomor A, Pytlik R, Lissmats A, Johnsen HE, de Witte T, Einsele H, Ruutu T, Niederwieser D; CLWP of the EBMT. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden. Bone Marrow Transplant. 2013 Jul;48(7):966-71. doi: 10.1038/bmt.2012.257. 80. Le QT, Kim HE, Schneider CJ, Muraközy G, Skladowski K, Reinisch S, Chen Y, Hickey M, Mo M, Chen MG, Berger D, Lizambri R, Henke M. Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study. J Clin Oncol. 2011 Jul 10;29(20):2808-14. doi: 10.1200/JCO.2010.32.4095. 81. Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S. Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracilbased chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer. 2008 Apr 1;112(7):1600-6. doi: 10.1002/cncr.23328. 82. Vokurka S, Bystricka E, Scudlova J, Mazur E, Visokaiova M, Vasilieva E, Brandejsova R, Chvojkova I, Vrabcova M, Vitkova J, Mjartanova D, Vodickova M, Bockova J, Streinerova K. The risk factors for oral mucositis and the effect of cryotherapy in patients after the BEAM and HD-l-PAM 200 mg/m(2) autologous hematopoietic stem cell transplantation. Eur J Oncol Nurs. 2011 Dec;15(5):508-12. doi: 10.1016/j.ejon.2011.01.006. 83. Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019 Jan 22;55(2):25. doi: 10.3390/medicina55020025. 84. Plevová P. Prevention and treatment of chemotherapy- and radiotherapyinduced oral mucositis: a review. Oral Oncol. 1999 Sep;35(5):453-70. doi: 10.1016/s1368-8375(99)00033-0. 85. Kührer I, Kuzmits R, Linkesch W, Ludwig H. Topical PGE2 enhances healing of chemotherapy-associated mucosal lesions. Lancet. 1986 Mar 15;1(8481):623. doi: 10.1016/s0140-6736(86)92850-3. 86. Carl W, Emrich LS. Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. J Prosthet Dent. 1991 Sep;66(3):361- 9. doi: 10.1016/0022-3913(91)90264-w. 36 87. Pavesi VC, Lopez TC, Martins MA et al. Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster. Support Care Cancer. 2011; 19:639– 46. 88. Dos Reis PE, Ciol MA, De Melo NS. Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: A pilot study. Support Care Cancer. 2016; 24:4393–8. 89. Oton-Leite AF, Elias LSA, Morais MO, Pinezi JCD, Leles CR, Silva MAGS, Mendonça EF. Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. Spec Care Dent 2013; 33(6): 294-300. 90. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM. Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – a triple blinded randomized controlled trial. Radiotherapy & Oncology 2012; 104: 349-354. 91. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM. Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients – A randomized controlled trial. Oral Oncol 2012; 48: 89-897. 92. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Nigudgi S. Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy--a randomized controlled trial. Supp. Care Cancer 2012; 21(5): 1421-1428. 93. Carvalho PAG, Jaguar GC, Pellizzon AC, Prado JD, Lopes RN, Alves FA. Evaluation of low-level laser therapy in the prevention and treatment of radiationinduced mucositis: a double-blind randomized study in head and neck cancer patients. Oral Oncol 2011; 47: 1176-1181. 94. Antunes HS, Herchenhorn D, Small IA, Araújo CMM, Viégas CMP, Cabral E, Rampini MP, Rodrigues PC, Silva TGP, Ferreira EMS, Dias FL, Ferreira CG. Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation. Radiotherapy & Oncology 2013; 109: 297-302. 95. Lima AG, Antequera R, Peres MPSM, Snitcosky IML, Federico MHH, Villar RC. Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis. Braz. Dent. J. 2010; 1(3): 186- 192. 96. Vladimirov YA, Osipov AN, Klebanov GI. Photobiological principles of therapeutic applications of laser radiation. Biochemistry (Mosc) 2004; 69: 81-89. 97. Maluf AP, Ughini GC, Maluf RP, Pagnoncelli RM. Utilização de laser terapêutico em exodontia de terceiros molares inferiores. 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| dc.title.pt_BR.fl_str_mv |
Mucosite oral decorrente do tratamento de câncer de mama |
| title |
Mucosite oral decorrente do tratamento de câncer de mama |
| spellingShingle |
Mucosite oral decorrente do tratamento de câncer de mama Pascoal, Daniela da Silva 4.02.00.00-0 Odontologia Neoplasia da mama Estomatite Terapia farmacológica |
| title_short |
Mucosite oral decorrente do tratamento de câncer de mama |
| title_full |
Mucosite oral decorrente do tratamento de câncer de mama |
| title_fullStr |
Mucosite oral decorrente do tratamento de câncer de mama |
| title_full_unstemmed |
Mucosite oral decorrente do tratamento de câncer de mama |
| title_sort |
Mucosite oral decorrente do tratamento de câncer de mama |
| author |
Pascoal, Daniela da Silva |
| author_facet |
Pascoal, Daniela da Silva Carvalho, Elda Lorrane Barros Sousa, Samara Agatha Augusto de |
| author_role |
author |
| author2 |
Carvalho, Elda Lorrane Barros Sousa, Samara Agatha Augusto de |
| author2_role |
author author |
| dc.contributor.advisor1.fl_str_mv |
Pavan, Ludmila Madeira Cardoso |
| dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1000030122409051 |
| dc.contributor.authorLattes.fl_str_mv |
... |
| dc.contributor.author.fl_str_mv |
Pascoal, Daniela da Silva Carvalho, Elda Lorrane Barros Sousa, Samara Agatha Augusto de |
| contributor_str_mv |
Pavan, Ludmila Madeira Cardoso |
| dc.subject.cnpq.fl_str_mv |
4.02.00.00-0 Odontologia |
| topic |
4.02.00.00-0 Odontologia Neoplasia da mama Estomatite Terapia farmacológica |
| dc.subject.por.fl_str_mv |
Neoplasia da mama Estomatite Terapia farmacológica |
| description |
A incidência global de câncer duplicou nos últimos 30 anos, sendo que nas mulheres, o câncer de mama é o tipo que mais acomete. Atualmente, os tratamentos mais utilizados para o câncer de mama incluem tratamento localizado com radioterapia, cirurgia com reconstrução mamária, quando necessário, quimioterapia, terapia biológica, e hormonioterapia. O tratamento quimioterápico pode apresentar complicações orais em cerca de 40% dos pacientes oncológicos. Este tratamento possui efeito citotóxico em diferentes tipos celulares, e desta forma dependendo da posologia e do tipo de quimioterápico utilizado uma série de efeitos adversos podem evoluir em graus leves a graves. A mucosite é uma complicação oral muito frequente nestes pacientes e apresenta-se como eritema, seguido de ulcerações dolorosas na mucosa bucal, que influenciam na capacidade de nutrição e na qualidade de vida dos pacientes, o que pode até limitar ou adiar o planejamento da terapia oncológica. |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020 |
| dc.date.accessioned.fl_str_mv |
2021-01-26T18:15:55Z |
| dc.date.available.fl_str_mv |
2021-01-26 2021-01-26T18:15:55Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
| format |
bachelorThesis |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/1377 |
| url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/1377 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.references.pt_BR.fl_str_mv |
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. 2. Taichman L. Oral Health-Related Complications of Breast Cancer Treatment: Assessing Dental Hygienists' Knowledge and Professional Practice. Journal of dental hygiene: JDH vol. 89 Suppl 2,Suppl 2 (2015): 22-37. 3. Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. – Rio de Janeiro: INCA, 2019. Disponível em:<www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020- incidencia-de-cancer-no-brasil.pdf> 4. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941-53. 5. INCA. Instituto Nacional do Câncer: Estadiamento. 2019. Disponível em: <www.inca.gov.br/estadiamento>. 6. Brasil. Portaria conjunta Nª 19, de 3 de Julho de 2018. Diretrizes Diagnósticas e Terapêuticas – Carcinoma de Mama. Ministério da saúde. De Julho de 2018. Disponível em: www.saude.gov.br/images/pdf/2018/julho/16/Portaria-Conjunta-n-19-- PCDT-Carcinoma-de-Mama.pdf 7. Marinho, PML. Mucosite oral por quimioterapia e qualidade de vida relacionada a saúde de mulheres com câncer de mama, Tese de doutorado: Ribeirão preto. Escola de enfermagem de Ribeirão Preto da Universidade de São Paulo;2020. 8. INCA. Instituto Nacional do Câncer: Como se comportam as células cancerosas. 2020. Disponível em: <www.inca.gov.br/como-se-comportam-celulascancerosas>. 9. INCA. Instituto Nacional do Câncer: Como surge o câncer. 2019. Disponível em: <www1.inca.gov.br/impressao.asp?op=cv&id=319>. 10. INCA. Instituto Nacional do Câncer: Câncer de mama. 2020. Disponível em: <www.inca.gov.br/tipos-de-cancer/cancer-de-mama>. 11. American cancer society. Cancer facts & figures 2019. Atlanta: American Cancer Society, 2019ª. Disponível em: www.cancer.org/content/dam/cancerorg/ research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breastcancer- facts-and-figures-2019-2020.pdf 12. Shao J, Wu L, Leng WD, Fang C, Zhu YJ, Jin YH. Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants. Front. Oncol. 2018; 8:601. 30 13. Sfreddo CS, Maier J, De David SC, Susin C, Moreira CHC. Periodontitis and breast cancer: A case-control study. Community Dent Oral Epidemiol. 2017 Dec;45(6):545-551. doi: 10.1111/cdoe.12318. 14. Kumar, S. Principles of cancer treatment by immunotherapy. Surgery, [s. l.],v. 30, n. 4, p. 198-202, 2012. DOI 10.1016/j.mpsur.2012.01.009. 15. Kakimi K, Karasaki T, Matsushita H, Sugie T. Advances in personalized cancer immunotherapy. Breast Cancer. 2017 Jan;24(1):16-24. 16. INCA. Instituto Nacional do Câncer: Tratamento do câncer. Quimioterapia. 2018. Disponível em: www.inca.gov.br/tratamento/quimioterapia 17. Caldeira MB, Galbiatti-Dias SLA. Acompanhamento e avaliação dos efeitos adversos da quimioterapia em pacientes com câncer de mama. 2017. 2p. União das Faculdades dos Grandes Lagos, sp. 18. Curra, M. Chemotherapy protocols and incidence of oral mucositis: an integrative review. Revista Einstein, v. 16, n. 1, p. 1-9, 2018. 19. Goyri, BLM.; Ramos, MEC.; Pérez, EE. Chemotherapy-induced oral stomatotoxicity. Revista Odontológica Mexicana, v. 18, n. 2, p. 89–95, 2014. 20. INCA. Diretrizes para a detecção precoce do câncer de mama no Brasil. 1. ed. INCA, 2015. 168p. Disponível em: www.inca.gov.br/publicacoes/livros/diretrizespara- deteccao-precoce-do-cancer-de-mama-no-brasil 21. Patussi C, Sassi ML, Munhoz CE, Zanicotti STR, Schussel LJ. A avaliação clínica da mucosite oral e candidíase é comparada ao nadir quimioterápico em pacientes transplantados. Braz. oral res. [online]. 2014. 22. Marinho PML. Mucosite oral por quimioterapia e qualidade de vida relacionada à saúde de mulheres com câncer de mama [tese]. Ribeirão Preto: , Escola de Enfermagem de Ribeirão Preto; 2020. 23. Sasada INV, Munerato MC, Gregianin LJ. Mucosite oral em crianças com câncer – [Revisão de literatura]. RFO, Passo Fundo. 2013;18(3):345-50. 24. Araújo, SNM. Cancer patients with oral mucositis: challenges for nursing care. Revista Latino-Americana de Enfermagem [online], v. 23, n. 2, p. 267–274, 2015b 25. Goyri, BLM.; Ramos, MEC.; Pérez, EE. Chemotherapy-induced oral stomatotoxicity. Revista Odontológica Mexicana, v. 18, n. 2, p. 89–95, 2014. 26. Morais, JR. Characterization of the patient with chemotherapy-induced oral mucositis. Revista de Enfermagem da UFPI, v. 4, n. 1, p. 26–32, 2015. 27. Musso MAA. Associação das Manifestações Bucais com Variáveis Sociodemográficas e Clínicas em Mulheres com Câncer de Mama. Revista Brasileira de Ciências da Saúde, v. 22, n. 3, p. 203-212, 2018. 31 28. Petersson, DE. Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice. Cancer Medicine, v. 5, n. 8, p. 1897-1907, 2016. 29. Seiler S. Adverse event management of oral mucositis in patients with breast cancer. Breast Care, v. 9, n. 4, p. 232–237, 2014. 30. Volpato LER.; Silva TC.; Oliveira TM; Sakai, VT; Machado MAAM. Mucosite bucal rádio e quimioinduzida. Revista brasileira de otorrinolaringologia., São Paulo, v.73, n.4, Ago. 2007. 31. Rampini MP, Ferreira EMS, Ferreira CG, Antunes HS. Utilização da terapia com laser de baixa potencias para prevenção de mucosite oral: revisão de literatura. Revista Brasileira de Cancerologia.2009;55(1): 59-68. 32. Katranci N. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - A randomized controlled trial. European Journal of Oncology Nursing, v.16, p. 339-44, 2012. 33. Fligiola SLC. Fatores de risco para mucosite bucal em pacientes com leucemia linfóide aguda submetidos a diferentes protocolos de tratamento [tese]. Bauru (SP): Universidade de São Paulo; 2007. 34. Sonis ST. Pathobiology of oral mucositis: novel insights and opportunities. Supportive Oncology, v. 5, n.9, p. 3-11, 2007. 35. Cuba LF, Salum F, Cherubini K, Figueiredo MAZ. Antioxidant agents: A future alternative approach in the prevention and treatment of radiation-induced oral mucositis? Altern Ther Health Med. 2015;21(2):36-41. 36. Sonis ST. A biological approach to mucositis. J Supportive Oncology. 2004;2(1):21-32; discussion 35-6. 37. Cidon U. Chemotherapy induced oral mucositis: prevention is possible. Medical Oncology. 2017; 1-7. 38. Marín-Conde F, Castellanos-Cosano L., Pachón-Ibañez J, Serrera-Figallo MA., Gutiérrez-Pérez JL.,Torres-Lagares D. Photobiomodulation with low-level laser therapy reduces oral mucositis caused by head and neck radio-chemotherapy: prospective randomized controlled trial. International Journal of Oral and Maxillofacial. 2018. 39. World Health Organization. (1979). WHO handbook for reporting results of cancer treatment. World Health Organization. Disponível em:<https://apps.who.int/iris/handle/10665/37200> 40. Abdel Moneim AE, Guerra-Librero A., Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D, Escames G. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int J Mol Sci. 2017 May 7;18(5):1003. 32 41. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014 May; 120(10):1453-61. 42. Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dent Clin North Am. 2008 Jan; 52(1):61-77. 43. Lalla RV, Saunders DP, Peterson DE. Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am. 2014 Apr; 58(2):341-9. 44. Brito CA, Araújo DS, Granja JG, Souza SM, Lima MAG, Oliveira MC. Efeito da clorexidina e do laser de baixa potência na prevenção e no tratamento da mucosite oral. Rev Odontol UNESP. 2012 Jul-Ago; 41(4):236-41. 45. Campos MIDC, Campos CN, Aarestrup FM, Aarestrup BJV. Oral mucositis in cancer treatment: Natural history, prevention and treatment. Mol Clin Oncol. 2014;2(3):337–40. 46. Mallick S, Benson, Rath GK. Radiation induced oral mucositis: a review of current literature on prevention and management. Eur Arch Otorhinolaryngol. 2015. 47. Henke M, Alfonsi M, Foa P, Giralt J, Bardet E, Cerezo L, Salzwimmer M, Lizambri R, Emmerson L, Chen MG, Berger D. Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trial. J Clin Oncol. 2011;9(20):2815–2820. 48. Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH. Effects of honey on oral mucositis in patients with head and neck cancer: A meta analysis. Laryngoscope. 2015; 125: 2085-2092. 49. Hawley P, Hovan A, McGahan CE, Saunders D. A randomized placebocontrolled trial of manuka honey for radiation – induced oral mucositis. Support Care Cancer. 2014; 22: 751-761. 50. Raeessi MA, Raeessi N, Panahi Y, Gharaie H, Davoudi SM, Saadat A, Zarchi AAK, Raeessi F, Ahmadi SM, Jalalian H. “Coffee plus honey” versus “topical steroid” in the treatment of chemotherapy-induced oral mucositis: a randomized controlled trial. BMC Complement Altern Med. 2014; 14:293. 51. Urbain P. Role of antioxidants in buccal mucosa cells and plasma on the incidence and severity of oral mucositis after allogeneic haematopoietic cell transplantation. Supportive Care in Cancer, v. 20, p. 1831–1838, 2012. 52. Santos, SB. O efeito da vitamina E e do selênio na prevenção da mucosite em pacientes com tumores malignos nas vias aerodigestivas superiores submetidos a radioterapia, concomitantemente ou não com quimioterapia [dissertação]. São Paulo: Universidade de São Paulo, Faculdade de Medicina; 2009. 53. Lederer, J. 1990. Alimentação e câncer. 3a edição. Editora Malone Dois, São Paulo. 33 54. Oveissi V, Ram M, Bahramsoltani R. Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective. Daru; 2019. 55. Chandrashekhar VM, Ranpariya VL, Ganapaty S. Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats. J Ethnopharmacol. 2010; 127(3):645–51 56. Salehi B, Lopez-Jornet P, Pons-Fuster López E, Calina D, Sharifi-Rad M, Ramírez-Alarcón K, Forman K, Fernández M, Martorell M, Setzer WN, Martins N, Rodrigues CF, Sharifi-Rad J. Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. Biomolecules. 2019 Mar 17;9(3):106. 57. Miranda P.M, Souza S.D. Glutamina na Prevenção e Tratamento da Mucosite em Pacientes Adultos Oncológicos: uma Revisão Sistemática da Literatura. Revista Brasileira de Cancerologia 2015; 61(3): 277-285. 58. Peterson DE, Jones JB, Petit RG. Randomized, Placebo controlled trial of saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy. Cancer. 2007;109(2):322-31 59. Centurion BS; Garcias AS; Rubira-Bullen IRF; Santos PSS. Avaliação clínica e tratamento das complicações bucais pós quimioterapia e radioterapia., 66, 2, pp. 136-141. ISSN 0004-5276. 60. Rubenstein EB. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer, New York, v.100, n.9, p.2026-2046, May 2004. 61. Guimarães JJ. Tratamento das manifestações estomatológicas antes, no decorrer e depois de quimio e radioterapia. In: MARCUCCI, G. Fundamentos de odontologia: estomatologia. Rio de Janeiro: Guanabara Koogan, 2005. p.205-212. 62. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 2007;109:820–31 63. Cerchietti L. Morphine mouthwashes for painful mucositis. Support Care Cancer. 2007;15:115–6 64. Vayne-Bossert P, Escher M, de Vautibault CG, Dulguerov P, Allal A, Desmeules J, et al. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: A randomized double-blinded study. J Palliat Med. 2010;13:125–8. 65. Charbaji N, Schäfer-Korting M, Küchler S. Morphine stimulates cell migration of oral epithelial cells by delta-opioid receptor activation. PLoS One. 2012;7:e42616. 34 66. Xing SZ, Zhang Y. Efficacy and safety of transdermal fentanyl for the teratment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma. Support Care Cancer. 2015 Mar; 23(3):753-9. 67. Oberoi S., Zamperlini-Netto G., Beyene J., Treister NS, Sung L. Low-level laser therapy and laser debridement for management of oral mucositis in patients with head and neck cancer receiving chemotherapy and radiation. PLoS ONE. 2014; 9 : e107418. doi: 10.1371 / journal.pone.0107418 68. Alvarino-Martin C., Sarrion-Perez MG. Prevention and treatment of oral mucositis in patients receiving chemotherapy J. Clin. Exp. Dente. 2014; 6 : e74 – e80. doi: 10.4317 / jced.51313. 69. Allan E., Barney C., Baum S., Kessling T., Diavolitsis VM, Blakaj D., Grecula JC, Rocco JW, van Putten M., Bhatt AD. Low-level laser therapy and laser debridement for management of oral mucositis in patients with head and neck cancer receiving chemotherapy and radiation. Int. J. Radiat. Oncol. Biol. Phys. 2016; 94 : 883. doi: 10.1016 / j.ijrobp.2015.12.066. 70. Spezzia S. Mucosite oral. J Oral Invest, 4(1): 14-18, 2015 - ISSN 2238-510X 71. Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol,1998; 34(1): 39- 43. 72. Brugnera JA. Atlas de laserterapia aplicada à clínica odontológica. 1a. ed. São Paulo: Ed. Santos, 2003. 73. Hespanhol FL, Tinoco BEM, Teixeira HGC, Falabella MEV, Assis NMSP. Manifestações bucais em pacientes submetidos à quimioterapia. Ciênc Saúde Coletiva 2010;15(Supl 1):1085-94. 74. Amadori F, Bardellini E, Conti G, Pedrini N, Schumacher RF, Majorana A. Low-level laser therapy for treatment of chemotherapy- induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers Med Sci. 2016;31;(6):1231-6. 75. Cruz LB, Ribeiro AS, Rech A, Rosa LGN, Castro CG Jr, Bruneto AL. Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy. Pediatr Blood Cancer. 2007;48(4):435-40. 76. Kashiwazaki H ; Matsushita T ; Sugita J; Shigematsu A ; Kasashi K ; Yamazaki Y ; Kanehira T ; Yamamoto S ; Kondo T ; Endo T. Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer. 2012 Feb;20(2):367-73. doi: 10.1007/s00520-011-1116-x. 77. Yokota T; Tachibana H; Konishi T ; Yurikusa T ; Hamauchi, S; Sakai K; Nishikawa M; Suzuki M; Naganawa Y; Hagihara T. Multicenter phase II study of an oral care program for patients with head and neck cancer receiving 35 chemoradiotherapy. Support Care Cancer. 2016 Jul;24(7):3029-36. doi: 10.1007/s00520-016-3122-5. 78. Bradstock, KF; Link, E .; Collins, M .; Di Iulio, J .; Lewis, ID; Schwarer, A .; Enno, A .; Marlton, P .; Hahn, U .; Szer, J. A randomized trial of prophylactic palifermin on gastrointestinal toxicity after intensive induction therapy for acute myeloid leukaemia. Br J Haematol. 2014 Dec;167(5):618-25. doi: 10.1111/bjh.13086. 79. Blijlevens N, de Château M, Krivan G, Rabitsch W, Szomor A, Pytlik R, Lissmats A, Johnsen HE, de Witte T, Einsele H, Ruutu T, Niederwieser D; CLWP of the EBMT. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden. Bone Marrow Transplant. 2013 Jul;48(7):966-71. doi: 10.1038/bmt.2012.257. 80. Le QT, Kim HE, Schneider CJ, Muraközy G, Skladowski K, Reinisch S, Chen Y, Hickey M, Mo M, Chen MG, Berger D, Lizambri R, Henke M. Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study. J Clin Oncol. 2011 Jul 10;29(20):2808-14. doi: 10.1200/JCO.2010.32.4095. 81. Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S. Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracilbased chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer. 2008 Apr 1;112(7):1600-6. doi: 10.1002/cncr.23328. 82. Vokurka S, Bystricka E, Scudlova J, Mazur E, Visokaiova M, Vasilieva E, Brandejsova R, Chvojkova I, Vrabcova M, Vitkova J, Mjartanova D, Vodickova M, Bockova J, Streinerova K. The risk factors for oral mucositis and the effect of cryotherapy in patients after the BEAM and HD-l-PAM 200 mg/m(2) autologous hematopoietic stem cell transplantation. Eur J Oncol Nurs. 2011 Dec;15(5):508-12. doi: 10.1016/j.ejon.2011.01.006. 83. Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019 Jan 22;55(2):25. doi: 10.3390/medicina55020025. 84. Plevová P. Prevention and treatment of chemotherapy- and radiotherapyinduced oral mucositis: a review. Oral Oncol. 1999 Sep;35(5):453-70. doi: 10.1016/s1368-8375(99)00033-0. 85. Kührer I, Kuzmits R, Linkesch W, Ludwig H. Topical PGE2 enhances healing of chemotherapy-associated mucosal lesions. Lancet. 1986 Mar 15;1(8481):623. doi: 10.1016/s0140-6736(86)92850-3. 86. Carl W, Emrich LS. Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. J Prosthet Dent. 1991 Sep;66(3):361- 9. doi: 10.1016/0022-3913(91)90264-w. 36 87. Pavesi VC, Lopez TC, Martins MA et al. Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster. Support Care Cancer. 2011; 19:639– 46. 88. Dos Reis PE, Ciol MA, De Melo NS. Chamomile infusion cryotherapy to prevent oral mucositis induced by chemotherapy: A pilot study. Support Care Cancer. 2016; 24:4393–8. 89. Oton-Leite AF, Elias LSA, Morais MO, Pinezi JCD, Leles CR, Silva MAGS, Mendonça EF. Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. Spec Care Dent 2013; 33(6): 294-300. 90. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM. Low level laser therapy for concurrent chemoradiotherapy induced oral mucositis in head and neck cancer patients – a triple blinded randomized controlled trial. Radiotherapy & Oncology 2012; 104: 349-354. 91. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Vadhiraja BM. Low level helium neon laser therapy for chemoradiotherapy induced oral mucositis in oral cancer patients – A randomized controlled trial. Oral Oncol 2012; 48: 89-897. 92. Gautam AP, Fernandes DJ, Vidyasagar MS, Maiya AG, Nigudgi S. Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy--a randomized controlled trial. Supp. Care Cancer 2012; 21(5): 1421-1428. 93. Carvalho PAG, Jaguar GC, Pellizzon AC, Prado JD, Lopes RN, Alves FA. Evaluation of low-level laser therapy in the prevention and treatment of radiationinduced mucositis: a double-blind randomized study in head and neck cancer patients. Oral Oncol 2011; 47: 1176-1181. 94. Antunes HS, Herchenhorn D, Small IA, Araújo CMM, Viégas CMP, Cabral E, Rampini MP, Rodrigues PC, Silva TGP, Ferreira EMS, Dias FL, Ferreira CG. Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation. Radiotherapy & Oncology 2013; 109: 297-302. 95. Lima AG, Antequera R, Peres MPSM, Snitcosky IML, Federico MHH, Villar RC. Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis. Braz. Dent. J. 2010; 1(3): 186- 192. 96. Vladimirov YA, Osipov AN, Klebanov GI. Photobiological principles of therapeutic applications of laser radiation. Biochemistry (Mosc) 2004; 69: 81-89. 97. Maluf AP, Ughini GC, Maluf RP, Pagnoncelli RM. Utilização de laser terapêutico em exodontia de terceiros molares inferiores. RGO 2006; 54: 182-184 |
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