Morphometrical analysis of the coronary arteries in human fetuses
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/23725 |
Resumo: | Coronary arteries anatomical variations in humans have presented great clinical interest for resulting in a better understanding of cardiac pathological processes. This study aimed to analyze the morphometry of the coronary arteries of human cadavers from the fourth to the ninth month of intrauterine life. A total of 62 hearts from formalin-fixed Brazilian fetuses, with gestational ages ranging from 16 to 36 weeks, equally distributed as to gender and fetal age in each group, were analyzed. The dissection procedure was performed by removing the heart with the lungs in “monoblocks”. The length of the arteries under study was determined using a flexible tape placed along the vessels and later measured with a pachymeter. Additionally, histological analysis of the coronary artery tissues was performed to quantify the elastic fibers. The data were analyzed through two-way ANOVA, followed by Student-Newman-Keuls post hoc analysis, considering p < 0.05. When comparing the length of the right coronary artery (RCA) in fetuses between the second and third trimester a statistically significant difference was found for both males (p = 0.04) and females (p = 0.04). No statistically significant difference was found when comparing the left coronary artery (LCA) length between second and third trimester in male (p = 0.07) and female (p = 0.09) fetuses. We noticed a similar growth pattern between male and female fetuses and early development of LCA in relation to RCA. |
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Morphometrical analysis of the coronary arteries in human fetusesAnálisis morfométrico de las arterias coronarias en fetos humanosAnálise morfométrica das artérias coronárias em fetos humanosMorfologiaAnatomiaVasos coronáriosCoração.MorfologíaAnatomíaVasos coronariosCorazón.MorphologyAnatomyCoronary vesselsHeart.Coronary arteries anatomical variations in humans have presented great clinical interest for resulting in a better understanding of cardiac pathological processes. This study aimed to analyze the morphometry of the coronary arteries of human cadavers from the fourth to the ninth month of intrauterine life. A total of 62 hearts from formalin-fixed Brazilian fetuses, with gestational ages ranging from 16 to 36 weeks, equally distributed as to gender and fetal age in each group, were analyzed. The dissection procedure was performed by removing the heart with the lungs in “monoblocks”. The length of the arteries under study was determined using a flexible tape placed along the vessels and later measured with a pachymeter. Additionally, histological analysis of the coronary artery tissues was performed to quantify the elastic fibers. The data were analyzed through two-way ANOVA, followed by Student-Newman-Keuls post hoc analysis, considering p < 0.05. When comparing the length of the right coronary artery (RCA) in fetuses between the second and third trimester a statistically significant difference was found for both males (p = 0.04) and females (p = 0.04). No statistically significant difference was found when comparing the left coronary artery (LCA) length between second and third trimester in male (p = 0.07) and female (p = 0.09) fetuses. We noticed a similar growth pattern between male and female fetuses and early development of LCA in relation to RCA.Las variaciones anatómicas de las arterias coronarias en los seres humanos presentan un gran interés clínico por resultar en una mejor comprensión de los procesos patológicos cardíacos. Este estudio se propuso analizar la morfometría de las arterias coronarias de cadáveres humanos desde el cuarto hasta el noveno mes de vida intrauterina. Se analizaron un total de 62 corazones de fetos brasileños fijados en formol, con edades gestacionales de 16 a 36 semanas, distribuidos equitativamente respecto al género y la edad fetal en cada grupo. El procedimiento de disección se realizó extrayendo el corazón con los pulmones en monobloques. La longitud de las arterias en estudio se midió con una cinta flexible colocada a lo largo de los vasos y posteriormente se midió con un paquímetro. Asimismo, se realizó un análisis histológico de los tejidos de las arterias coronarias para cuantificar las fibras elásticas. Los datos se analizaron mediante ANOVA de dos vías, seguido de un análisis post hoc de Student-Newman-Keuls, considerando p < 0.05. Al comparar la longitud de la arteria coronaria derecha (ACD) en los fetos entre el segundo y el tercer trimestre, se encontró una diferencia estadísticamente significativa tanto en los varones (p = 0,04) como en las mujeres (p = 0,04). No se encontraron diferencias estadísticamente significativas al comparar la longitud de la arteria coronaria izquierda (ACI) entre el segundo y el tercer trimestre en fetos masculinos (p = 0,07) y femeninos (p = 0,09). Se observó un patrón de crecimiento similar entre los fetos masculinos y femeninos y un desarrollo temprano del ACI en relación con el ACD.Variações anatômicas das artérias coronárias em humanos têm apresentado grande interesse clínico por resultar em melhor entendimento dos processos patológicos cardíacos. Este estudo objetivou analisar a morfometria das artérias coronárias de cadáveres humanos do quarto ao nono mês de vida intrauterina. Um total de 62 corações de fetos brasileiros fixados em formalina, com idades gestacionais de 16 a 36 semanas, distribuídos igualmente quanto ao gênero e a idade fetal em cada grupo, foram analisados. O procedimento de dissecação foi realizado por retirada do coração com os pulmões em monoblocos. O comprimento das artérias em estudo foi mensurado através de fita flexível disposta ao longo dos vasos e posteriormente medida com paquímetro. Além disso, procedeu-se com análise histológica dos tecidos das artérias coronárias para quantificação das fibras elásticas. Os dados foram analisados através da Análise de Variância de dois fatores (Two way-ANOVA), seguido pelo post hoc de Student-Newman-Keuls, considerando p < 0.05. Quando comparado o comprimento da artéria coronária direita (ACD) em fetos entre o segundo e o terceiro trimestre foi encontrada diferença estatisticamente significativa tanto para o gênero masculino (p = 0.04) quanto feminino (p = 0.04). Não se encontrou diferença estatisticamente significativa ao se comparar o comprimento da artéria coronária esquerda (ACE) entre segundo e terceiro trimestre em fetos masculinos (p = 0.07) e femininos (p = 0.09). Percebeu-se a existência de padrão de crescimento semelhante entre fetos masculinos e femininos e desenvolvimento precoce da ACE em relação à ACD.Research, Society and Development2021-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2372510.33448/rsd-v10i16.23725Research, Society and Development; Vol. 10 No. 16; e340101623725Research, Society and Development; Vol. 10 Núm. 16; e340101623725Research, Society and Development; v. 10 n. 16; e3401016237252525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23725/20988Copyright (c) 2021 Diogo Costa Garção; Matheus Boaventura Santos; José Nolasco de Carvalho Neto; Alisson Guilherme da Silva Correia; Pedro Costa Pereira; Roberta Coelho de Andrade; Byanka Porto Fraga; Olga Sueli Marques Moreira; Ana Denise Santana de Oliveira; Vera Lúcia Correia Feitosahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGarção, Diogo CostaSantos, Matheus BoaventuraCarvalho Neto, José Nolasco de Correia, Alisson Guilherme da SilvaPereira, Pedro CostaAndrade, Roberta Coelho deFraga, Byanka PortoMoreira, Olga Sueli MarquesOliveira, Ana Denise Santana deFeitosa, Vera Lúcia Correia2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/23725Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:30.392575Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Morphometrical analysis of the coronary arteries in human fetuses Análisis morfométrico de las arterias coronarias en fetos humanos Análise morfométrica das artérias coronárias em fetos humanos |
| title |
Morphometrical analysis of the coronary arteries in human fetuses |
| spellingShingle |
Morphometrical analysis of the coronary arteries in human fetuses Garção, Diogo Costa Morfologia Anatomia Vasos coronários Coração. Morfología Anatomía Vasos coronarios Corazón. Morphology Anatomy Coronary vessels Heart. |
| title_short |
Morphometrical analysis of the coronary arteries in human fetuses |
| title_full |
Morphometrical analysis of the coronary arteries in human fetuses |
| title_fullStr |
Morphometrical analysis of the coronary arteries in human fetuses |
| title_full_unstemmed |
Morphometrical analysis of the coronary arteries in human fetuses |
| title_sort |
Morphometrical analysis of the coronary arteries in human fetuses |
| author |
Garção, Diogo Costa |
| author_facet |
Garção, Diogo Costa Santos, Matheus Boaventura Carvalho Neto, José Nolasco de Correia, Alisson Guilherme da Silva Pereira, Pedro Costa Andrade, Roberta Coelho de Fraga, Byanka Porto Moreira, Olga Sueli Marques Oliveira, Ana Denise Santana de Feitosa, Vera Lúcia Correia |
| author_role |
author |
| author2 |
Santos, Matheus Boaventura Carvalho Neto, José Nolasco de Correia, Alisson Guilherme da Silva Pereira, Pedro Costa Andrade, Roberta Coelho de Fraga, Byanka Porto Moreira, Olga Sueli Marques Oliveira, Ana Denise Santana de Feitosa, Vera Lúcia Correia |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Garção, Diogo Costa Santos, Matheus Boaventura Carvalho Neto, José Nolasco de Correia, Alisson Guilherme da Silva Pereira, Pedro Costa Andrade, Roberta Coelho de Fraga, Byanka Porto Moreira, Olga Sueli Marques Oliveira, Ana Denise Santana de Feitosa, Vera Lúcia Correia |
| dc.subject.por.fl_str_mv |
Morfologia Anatomia Vasos coronários Coração. Morfología Anatomía Vasos coronarios Corazón. Morphology Anatomy Coronary vessels Heart. |
| topic |
Morfologia Anatomia Vasos coronários Coração. Morfología Anatomía Vasos coronarios Corazón. Morphology Anatomy Coronary vessels Heart. |
| description |
Coronary arteries anatomical variations in humans have presented great clinical interest for resulting in a better understanding of cardiac pathological processes. This study aimed to analyze the morphometry of the coronary arteries of human cadavers from the fourth to the ninth month of intrauterine life. A total of 62 hearts from formalin-fixed Brazilian fetuses, with gestational ages ranging from 16 to 36 weeks, equally distributed as to gender and fetal age in each group, were analyzed. The dissection procedure was performed by removing the heart with the lungs in “monoblocks”. The length of the arteries under study was determined using a flexible tape placed along the vessels and later measured with a pachymeter. Additionally, histological analysis of the coronary artery tissues was performed to quantify the elastic fibers. The data were analyzed through two-way ANOVA, followed by Student-Newman-Keuls post hoc analysis, considering p < 0.05. When comparing the length of the right coronary artery (RCA) in fetuses between the second and third trimester a statistically significant difference was found for both males (p = 0.04) and females (p = 0.04). No statistically significant difference was found when comparing the left coronary artery (LCA) length between second and third trimester in male (p = 0.07) and female (p = 0.09) fetuses. We noticed a similar growth pattern between male and female fetuses and early development of LCA in relation to RCA. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-12-13 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/23725 10.33448/rsd-v10i16.23725 |
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https://rsdjournal.org/index.php/rsd/article/view/23725 |
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10.33448/rsd-v10i16.23725 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
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https://rsdjournal.org/index.php/rsd/article/view/23725/20988 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 16; e340101623725 Research, Society and Development; Vol. 10 Núm. 16; e340101623725 Research, Society and Development; v. 10 n. 16; e340101623725 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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