Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review

Detalhes bibliográficos
Autor(a) principal: Silva, Josicléia Leôncio da
Data de Publicação: 2022
Outros Autores: Galdino, Diogo Magalhães da Costa, Araújo, Bruna Thays Santana de, Colaço, Elisabete Oliveira, Leite, Jéssica Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/35112
Resumo: Cardiovascular changes related to COVID-19 are being increasingly reported, revealing the need for further investigations. In this context, the autopsy is capable of providing illuminating evidence. Therefore, the objective of this research was to synthesize the main cardiovascular findings of patients affected by COVID-19, based on autopsies. Methodology: A search was carried out in the CINAHAL, Embase, Google Scholar, IBECS, LILACS, MEDLINE, Science Direct, SciELO, Scopus, and Web of Science databases. Results: 29 studies were included, totaling 496 autopsies of men and women (27-94 years), mainly with a history of hypertension, obesity and diabetes. Autopsies revealed thrombi in multiple regions (lung, heart, kidneys, testicles); right ventricular dilation; abundance of megakaryocytes; viral presence in the heart; and myocarditis. Final considerations: COVID-19 has a complex interaction with the cardiovascular system, proving capable of interfering with its homeostasis, with thrombosis being the main pathophysiological event of this disease.
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spelling Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative reviewCambios cardiovasculares evidenciados en autopsias de pacientes afectados por COVID-19: una revisión integradoraAlterações cardiovasculares evidenciadas em autópsias de pacientes acometidos pela COVID-19: uma revisão integrativaAutopsyCOVID-19SARS-CoV-2Cardiovascular system.AutopsiaCOVID-19SARS-CoV-2Sistema cardiovascular.AutópsiaCOVID-19SARS-CoV-2Sistema cardiovascular.Cardiovascular changes related to COVID-19 are being increasingly reported, revealing the need for further investigations. In this context, the autopsy is capable of providing illuminating evidence. Therefore, the objective of this research was to synthesize the main cardiovascular findings of patients affected by COVID-19, based on autopsies. Methodology: A search was carried out in the CINAHAL, Embase, Google Scholar, IBECS, LILACS, MEDLINE, Science Direct, SciELO, Scopus, and Web of Science databases. Results: 29 studies were included, totaling 496 autopsies of men and women (27-94 years), mainly with a history of hypertension, obesity and diabetes. Autopsies revealed thrombi in multiple regions (lung, heart, kidneys, testicles); right ventricular dilation; abundance of megakaryocytes; viral presence in the heart; and myocarditis. Final considerations: COVID-19 has a complex interaction with the cardiovascular system, proving capable of interfering with its homeostasis, with thrombosis being the main pathophysiological event of this disease.Los cambios cardiovasculares relacionados con COVID-19 se informan cada vez más, lo que revela la necesidad de realizar más investigaciones. En este contexto, la autopsia es capaz de proporcionar evidencia esclarecedora. Por ello, el objetivo de esta investigación fue sintetizar los principales hallazgos cardiovasculares de pacientes afectados por COVID-19, a partir de autopsias. Metodología: Se realizó una búsqueda en las bases de datos CINAHAL, Embase, Google Scholar, IBECS, LILACS, MEDLINE, Science Direct, SciELO, Scopus y Web of Science. Resultados: Se incluyeron 29 estudios, totalizando 496 autopsias de hombres y mujeres (27-94 años), principalmente con antecedentes de hipertensión, obesidad y diabetes. Las autopsias revelaron la existencia de trombos en múltiples regiones (pulmón, corazón, riñones, testículos); dilatación del ventrículo derecho; abundancia de megacariocitos; presencia viral en el corazón; y miocarditis. Consideraciones finales: el COVID-19 tiene una interacción compleja con el sistema cardiovascular, mostrándose capaz de interferir en su homeostasis, siendo la trombosis el principal evento fisiopatológico de esta enfermedad.Alterações cardiovasculares relacionadas à COVID-19 estão sendo cada vez mais relatadas, revelando a necessidade da realização de novas investigações. Nesse contexto, a autópsia é capaz de fornecer evidências elucidativas. Portanto, o objetivo desta pesquisa foi sintetizar os principais achados cardiovasculares de pacientes acometidos pela COVID-19, com base em autópsias. Metodologia: Realizou-se uma busca nas bases de dados CINAHAL, Embase, Google Scholar, IBECS, LILACS, MEDLINE, Science Direct, SciELO, Scopus, e Web of Science. Resultados: Foram inclusas 29 pesquisas, totalizando 496 autópsias de homens e mulheres (27-94 anos), principalmente, com histórico de hipertensão, obesidade e diabetes. As autópsias revelaram a existência de trombos em múltiplas regiões (pulmão, coração, rins, testículos); dilatação ventricular direita; abundancia de megacariócitos; presença viral no coração; e miocardite. Considerações finais: A COVID-19 possui uma complexa interação com o sistema cardiovascular, mostrando-se capaz de interferir em sua homeostasia, sendo a trombose o principal evento fisiopatológico desta doença.Research, Society and Development2022-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3511210.33448/rsd-v11i13.35112Research, Society and Development; Vol. 11 No. 13; e143111335112Research, Society and Development; Vol. 11 Núm. 13; e143111335112Research, Society and Development; v. 11 n. 13; e1431113351122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/35112/29557Copyright (c) 2022 Josicléia Leôncio da Silva; Diogo Magalhães da Costa Galdino; Bruna Thays Santana de Araújo; Elisabete Oliveira Colaço; Jéssica Costa Leitehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Josicléia Leôncio da Galdino, Diogo Magalhães da Costa Araújo, Bruna Thays Santana de Colaço, Elisabete Oliveira Leite, Jéssica Costa 2022-10-17T13:43:46Zoai:ojs.pkp.sfu.ca:article/35112Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:50:08.709613Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
Cambios cardiovasculares evidenciados en autopsias de pacientes afectados por COVID-19: una revisión integradora
Alterações cardiovasculares evidenciadas em autópsias de pacientes acometidos pela COVID-19: uma revisão integrativa
title Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
spellingShingle Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
Silva, Josicléia Leôncio da
Autopsy
COVID-19
SARS-CoV-2
Cardiovascular system.
Autopsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
Autópsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
title_short Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
title_full Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
title_fullStr Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
title_full_unstemmed Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
title_sort Cardiovascular changes evidenced in autopsies of patients affected by COVID-19: an integrative review
author Silva, Josicléia Leôncio da
author_facet Silva, Josicléia Leôncio da
Galdino, Diogo Magalhães da Costa
Araújo, Bruna Thays Santana de
Colaço, Elisabete Oliveira
Leite, Jéssica Costa
author_role author
author2 Galdino, Diogo Magalhães da Costa
Araújo, Bruna Thays Santana de
Colaço, Elisabete Oliveira
Leite, Jéssica Costa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Josicléia Leôncio da
Galdino, Diogo Magalhães da Costa
Araújo, Bruna Thays Santana de
Colaço, Elisabete Oliveira
Leite, Jéssica Costa
dc.subject.por.fl_str_mv Autopsy
COVID-19
SARS-CoV-2
Cardiovascular system.
Autopsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
Autópsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
topic Autopsy
COVID-19
SARS-CoV-2
Cardiovascular system.
Autopsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
Autópsia
COVID-19
SARS-CoV-2
Sistema cardiovascular.
description Cardiovascular changes related to COVID-19 are being increasingly reported, revealing the need for further investigations. In this context, the autopsy is capable of providing illuminating evidence. Therefore, the objective of this research was to synthesize the main cardiovascular findings of patients affected by COVID-19, based on autopsies. Methodology: A search was carried out in the CINAHAL, Embase, Google Scholar, IBECS, LILACS, MEDLINE, Science Direct, SciELO, Scopus, and Web of Science databases. Results: 29 studies were included, totaling 496 autopsies of men and women (27-94 years), mainly with a history of hypertension, obesity and diabetes. Autopsies revealed thrombi in multiple regions (lung, heart, kidneys, testicles); right ventricular dilation; abundance of megakaryocytes; viral presence in the heart; and myocarditis. Final considerations: COVID-19 has a complex interaction with the cardiovascular system, proving capable of interfering with its homeostasis, with thrombosis being the main pathophysiological event of this disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/35112
10.33448/rsd-v11i13.35112
url https://rsdjournal.org/index.php/rsd/article/view/35112
identifier_str_mv 10.33448/rsd-v11i13.35112
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/35112/29557
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 13; e143111335112
Research, Society and Development; Vol. 11 Núm. 13; e143111335112
Research, Society and Development; v. 11 n. 13; e143111335112
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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