Mastocytosis Colitis in 54 year old woman: A rare case report
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32410 |
Resumo: | Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic colitis, systemic mastocytosis with GI involvement. Methodology : Descriptive study of the case report type, data were obtained from the patient's record. Discussion and Conclusion : To rule out the differential diagnosis, an immunohistochemical examination and clinical correlation were performed. On histopathological examination, microscopic features showed the proliferation of mast cells in the aggregate only in the colon, without any other systemic manifestations, an increase in the number of mast cells >20/HPF was found in the colonic mucosa. The staining of CD117 on cells in the superficial (1/3 top) of the lamina propria suspected of being a mastocyte, supporting mastocytosis colitis. |
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Mastocytosis Colitis in 54 year old woman: A rare case report Mastocitosis Colitis en mujer de 54 años: Informe de un caso raroColite Mastocitose em mulher de 54 anos: Um relato de caso raroMastocitosis sistémicaColitis por mastocitosisMastocitosDiarrea crónica.Mastocytosis systemicMastocytosis colitisMast cellChronic diarrhea.Mastocitose sistêmicaColite de mastocitoseMastócitosDiarréia crônica.Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic colitis, systemic mastocytosis with GI involvement. Methodology : Descriptive study of the case report type, data were obtained from the patient's record. Discussion and Conclusion : To rule out the differential diagnosis, an immunohistochemical examination and clinical correlation were performed. On histopathological examination, microscopic features showed the proliferation of mast cells in the aggregate only in the colon, without any other systemic manifestations, an increase in the number of mast cells >20/HPF was found in the colonic mucosa. The staining of CD117 on cells in the superficial (1/3 top) of the lamina propria suspected of being a mastocyte, supporting mastocytosis colitis.Introducción: La mastocitosis es un trastorno raro que ocurre debido a la proliferación clonal neoplásica de mastocitos que se acumulan en uno o más sistemas de órganos. La mastocitosis sistémica generalmente se diagnostica después de la segunda década de vida, las proporciones informadas de hombre a mujer varían de 1: 1 a 1: 1.5. Descripción del caso: una mujer de 54 años acude con debilidad y diarrea desde hace 2 meses. Los síntomas son heces acuosas de 2 a 4 veces al día y náuseas. El examen físico encontró que la temperatura corporal era de 37,60C, taquicardia, aumento de los ruidos intestinales y dolor a la palpación en el estómago. Se realiza examen endoscópico con resultado: colon transverso aparece con pólipos de 3 mm de tamaño, con patrón de mucosa en mosaico. La mucosa del colon ascendente y ciego también parece tener un patrón de mosaico. Se envió biopsia para estudio histopatológico. Las características morfológicas muestran un aumento significativo de eosinófilos y mastocitos, diagnosticados diferencialmente con mastocitosis colitis, colitis eosinofílica, mastocitosis sistémica con afectación gastrointestinal. Metodología: Estudio descriptivo del tipo reporte de caso, los datos se obtuvieron de la historia clínica del paciente. Discusión y Conclusión: Para descartar el diagnóstico diferencial, se realizó un examen inmunohistoquímico y correlación clínica. En el examen histopatológico, las características microscópicas mostraron la proliferación de mastocitos en el agregado solo en el colon, sin otras manifestaciones sistémicas, se encontró un aumento en el número de mastocitos> 20/HPF en la mucosa colónica. La tinción de CD117 en células en la superficie (1/3 superior) de la lámina propia sospechosa de ser un mastocitos, apoyando colitis por mastocitosis.Introdução: A mastocitose é uma doença rara que ocorre devido à proliferação clonal neoplásica de mastócitos que se acumulam em um ou mais sistemas orgânicos. A mastocitose sistêmica é geralmente diagnosticada após a segunda década de vida, as relações entre homens e mulheres relatadas variam de 1:1 a 1:1,5. Descrição do caso: Uma mulher de 54 anos veio queixando-se de fraqueza e diarreia nos últimos 2 meses. Os sintomas são fezes aquosas por 2-4 vezes ao dia e náuseas. O exame físico constatou que a temperatura corporal era de 37,60C, taquicardia, sons intestinais aumentados e sensibilidade no estômago. Um exame endoscópico foi realizado com resultados: cólon transverso aparece com pólipos com tamanho de 3 mm, com padrão de mosaico da mucosa. A mucosa do cólon ascendente e do ceco também parece ser um padrão de mosaico. A biópsia foi encaminhada para exame histopatológico. As características morfológicas mostram aumento significativo de eosinófilos e mastócitos, diagnosticados diferencialmente com colite mastocitose, colite eosinofílica, mastocitose sistêmica com envolvimento GI. Metodologia: Estudo descritivo do tipo relato de caso, os dados foram obtidos do prontuário do paciente. Discussão e Conclusão: Para afastar o diagnóstico diferencial, foi realizado exame imuno-histoquímico e correlação clínica. No exame histopatológico, as características microscópicas mostraram a proliferação de mastócitos no agregado apenas no cólon, sem outras manifestações sistêmicas, um aumento no número de mastócitos >20/HPF foi encontrado na mucosa colônica. A coloração de CD117 em células na superfície (1/3 superior) da lâmina própria suspeita de ser um mastócito, suportando a colite mastocitose.Research, Society and Development2022-09-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3241010.33448/rsd-v11i13.32410Research, Society and Development; Vol. 11 No. 13; e11111332410Research, Society and Development; Vol. 11 Núm. 13; e11111332410Research, Society and Development; v. 11 n. 13; e111113324102525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/32410/29424Copyright (c) 2022 Herman Saputra ; Ni Putu Sriwidyani ; Putu Erika Paskarani; Dandy Citrahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSaputra , Herman Sriwidyani , Ni Putu Paskarani, Putu Erika Citra, Dandy 2022-10-17T13:43:46Zoai:ojs.pkp.sfu.ca:article/32410Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:25.797552Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Mastocytosis Colitis in 54 year old woman: A rare case report Mastocitosis Colitis en mujer de 54 años: Informe de un caso raro Colite Mastocitose em mulher de 54 anos: Um relato de caso raro |
title |
Mastocytosis Colitis in 54 year old woman: A rare case report |
spellingShingle |
Mastocytosis Colitis in 54 year old woman: A rare case report Saputra , Herman Mastocitosis sistémica Colitis por mastocitosis Mastocitos Diarrea crónica. Mastocytosis systemic Mastocytosis colitis Mast cell Chronic diarrhea. Mastocitose sistêmica Colite de mastocitose Mastócitos Diarréia crônica. |
title_short |
Mastocytosis Colitis in 54 year old woman: A rare case report |
title_full |
Mastocytosis Colitis in 54 year old woman: A rare case report |
title_fullStr |
Mastocytosis Colitis in 54 year old woman: A rare case report |
title_full_unstemmed |
Mastocytosis Colitis in 54 year old woman: A rare case report |
title_sort |
Mastocytosis Colitis in 54 year old woman: A rare case report |
author |
Saputra , Herman |
author_facet |
Saputra , Herman Sriwidyani , Ni Putu Paskarani, Putu Erika Citra, Dandy |
author_role |
author |
author2 |
Sriwidyani , Ni Putu Paskarani, Putu Erika Citra, Dandy |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Saputra , Herman Sriwidyani , Ni Putu Paskarani, Putu Erika Citra, Dandy |
dc.subject.por.fl_str_mv |
Mastocitosis sistémica Colitis por mastocitosis Mastocitos Diarrea crónica. Mastocytosis systemic Mastocytosis colitis Mast cell Chronic diarrhea. Mastocitose sistêmica Colite de mastocitose Mastócitos Diarréia crônica. |
topic |
Mastocitosis sistémica Colitis por mastocitosis Mastocitos Diarrea crónica. Mastocytosis systemic Mastocytosis colitis Mast cell Chronic diarrhea. Mastocitose sistêmica Colite de mastocitose Mastócitos Diarréia crônica. |
description |
Introduction: Mastocytosis is a rare disorder occurring due to neoplastic clonal proliferation of mast cells accumulating in one or more organ systems. Systemic mastocytosis is generally diagnosed after the second decade of life, reported male-to-female ratios range from 1:1 to 1:1.5. Case description : A 54-year-old woman came complaining weakness and diarrhea for the last 2 months. Symptoms are watery stools for 2-4 times a day and nausea. Physical examination found that the body temperature was 37.60C, tachycardia, increased bowel sounds, and tenderness on stomach. An endoscopic examination was performed with results: transverse colon appears with polyps with a size of 3 mm, with a mosaic pattern of mucosa. The mucosa of the ascending colon and caecum also appears to be a mosaic pattern. Biopsy was sent for histopathological examination. Morphological features show significant increase of eosinophils & mast cells, differentially diagnosed with Mastocytosis colitis, Eosinophilic colitis, systemic mastocytosis with GI involvement. Methodology : Descriptive study of the case report type, data were obtained from the patient's record. Discussion and Conclusion : To rule out the differential diagnosis, an immunohistochemical examination and clinical correlation were performed. On histopathological examination, microscopic features showed the proliferation of mast cells in the aggregate only in the colon, without any other systemic manifestations, an increase in the number of mast cells >20/HPF was found in the colonic mucosa. The staining of CD117 on cells in the superficial (1/3 top) of the lamina propria suspected of being a mastocyte, supporting mastocytosis colitis. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32410 10.33448/rsd-v11i13.32410 |
url |
https://rsdjournal.org/index.php/rsd/article/view/32410 |
identifier_str_mv |
10.33448/rsd-v11i13.32410 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32410/29424 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Herman Saputra ; Ni Putu Sriwidyani ; Putu Erika Paskarani; Dandy Citra https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Herman Saputra ; Ni Putu Sriwidyani ; Putu Erika Paskarani; Dandy Citra https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 13; e11111332410 Research, Society and Development; Vol. 11 Núm. 13; e11111332410 Research, Society and Development; v. 11 n. 13; e11111332410 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052718347452416 |