Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)

Detalhes bibliográficos
Autor(a) principal: Aranha, Renata Emanuela Lyra de Brito
Data de Publicação: 2020
Outros Autores: Torro, Nelson, Andrade, Suellen Marinho de, Fernández-Calvo, Bernardino, Oliveira, Eliane Araújo de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/5768
Resumo: Chronic migraine (CM) has a wide range of symptoms, with debilitating consequences for those individuals refractory to the conventional treatments. In this context, Transcranial Direct Current Stimulation (tDCS) is a promising technique, although there is still no consensus on the most appropriate protocol, which may vary in relation to the number and interval between the application sessions. The present work consists of a protocol to assess the clinical and cognitive effects of ETCC on CM in the form of a double-blind, randomized and placebo-controlled clinical trial. The sample will consist of women aged between 20 and 45 years with a diagnosis of CM. A sociodemographic questionnaire and instruments for assessing cognitive functions, affective aspects, and clinical evaluation of migraine will be applied. Participants will be randomly distributed among 3 groups: Group 1: will receive a daily tDCS session for 15 minutes; Group 2: will receive two daily tDCS sessions of 15 minutes, with an interval of 20 minutes between them; Group 3: will receive simulated stimulation (sham) for 15 minutes. The anode electrode will be placed on the left dorsolateral prefrontal cortex and the reference electrode on the contralateral supraorbital region. In the Groups 1 and 2 the current will have an intensity of 2mA and will be applied for 10 consecutive days. We expect that tDCS will be effective in reducing symptoms in CM, with a decreased in pain and stress, and an improvement in the cognitive performance. This study will help to define a more appropriate neuromodulation protocol, contributing to the clinical decision making in CM.
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spelling Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)Comparación entre protocolos de Estimulación Transcraneal de Corriente Contínua em la Migraña Crónica (NEUROMIG)Comparação entre protocolos de Estimulação Transcraniana por Corrente Contínua na Migrânea Crônica (NEUROMIG)Estimulação transcraniana por corrente contínuaTestes neuropsicológicosTranstornos de enxaquecaDor.Estimulación transcraneal de corriente continuaPruebas neuropsicológicasTrastornos de migrañaDolor.Transcranial direct current stimulationNeuropsychological testsMigraine disordersPain.Chronic migraine (CM) has a wide range of symptoms, with debilitating consequences for those individuals refractory to the conventional treatments. In this context, Transcranial Direct Current Stimulation (tDCS) is a promising technique, although there is still no consensus on the most appropriate protocol, which may vary in relation to the number and interval between the application sessions. The present work consists of a protocol to assess the clinical and cognitive effects of ETCC on CM in the form of a double-blind, randomized and placebo-controlled clinical trial. The sample will consist of women aged between 20 and 45 years with a diagnosis of CM. A sociodemographic questionnaire and instruments for assessing cognitive functions, affective aspects, and clinical evaluation of migraine will be applied. Participants will be randomly distributed among 3 groups: Group 1: will receive a daily tDCS session for 15 minutes; Group 2: will receive two daily tDCS sessions of 15 minutes, with an interval of 20 minutes between them; Group 3: will receive simulated stimulation (sham) for 15 minutes. The anode electrode will be placed on the left dorsolateral prefrontal cortex and the reference electrode on the contralateral supraorbital region. In the Groups 1 and 2 the current will have an intensity of 2mA and will be applied for 10 consecutive days. We expect that tDCS will be effective in reducing symptoms in CM, with a decreased in pain and stress, and an improvement in the cognitive performance. This study will help to define a more appropriate neuromodulation protocol, contributing to the clinical decision making in CM.La migraña crónica (MC) tiene una amplia gama de síntomas, con consecuencias debilitantes para las personas refractarias a los tratamientos convencionales. En este contexto, la estimulación transcraneal de corriente continua (ETCC) se muestra como una técnica prometedora, aunque todavía no hay consenso sobre el protocolo más adecuado, que puede variar con relación al número e intervalo entre las sesiones de aplicación. El presente trabajo consiste en un protocolo para evaluar los efectos clínicos y cognitivos de ETCC en la MC en forma de un ensayo clínico doble ciego, aleatorizado y controlado con placebo. La muestra estará compuesta por mujeres de entre 20 y 45 años con diagnóstico de MC. Se aplicará un cuestionario sociodemográfico e instrumentos para evaluar las funciones cognitivas, los aspectos afectivos y la evaluación clínica de la migraña. Los participantes se distribuirán aleatoriamente entre 3 grupos: Grupo 1: recibirá una sesión diaria de ETCC durante 15 minutos; Grupo 2: recibirá dos sesiones diarias de ETCC de 15 minutos, con un intervalo de 20 minutos entre ellas; Grupo 3: recibirá estimulación simulada (sham) durante 15 minutos. El electrodo anódico se colocará en la corteza prefrontal dorsolateral izquierda y el electrodo de referencia en la región supraorbital contralateral. En los grupos 1 y 2, la corriente tendrá una intensidad de 2 mA y será aplicará durante 10 días consecutivos. Se espera que la ETCC sea eficaz para reducir el cuadro sintomático en la MC, con disminución del dolor, estrés y un mejor rendimiento cognitivo. Este estudio contribuirá a la definición de un protocolo de neuromodulación más apropiado, contribuyendo a la toma de decisiones clínicas en MC.A migrânea crônica (MC) possui um amplo conjunto de sintomas, com consequências debilitantes para os indivíduos refratários aos tratamentos convencionais. Neste contexto, a Estimulação Transcraniana por Corrente Contínua (ETCC) se mostra como uma técnica promissora, embora ainda não haja consenso sobre o protocolo mais adequado, que pode variar com relação ao número e intervalo entre as sessões de aplicação. O presente trabalho consiste em um protocolo de avaliação dos efeitos clínicos e cognitivos da ETCC na MC sob a forma de ensaio clínico duplo-cego, randomizado e placebo-controlado. A amostra será composta por mulheres com idade entre 20 e 45 anos com diagnóstico de MC. Serão aplicados um questionário sociodemográfico e instrumentos de avaliação das funções cognitivas, aspectos afetivos, e de avaliação clínica da migrânea. As participantes serão distribuídas aleatoriamente em 3 grupos: Grupo 1: receberá uma sessão diária de ETCC de 15 minutos; Grupo 2: receberá duas sessões diárias de ETCC de 15 minutos, com um intervalo de 20 minutos entre elas; Grupo 3: receberá estimulação do tipo simulada (sham) por 15 minutos. O eletrodo anódico será alocado na região do córtex pré-frontal dorsolateral esquerdo e o eletrodo de referência na região supra-orbital contralateral. Nos grupos 1 e 2 a corrente terá intensidade de 2mA e será aplicada durante 10 dias consecutivos. Espera-se que a ETCC seja eficaz na redução do quadro sintomático na MC, com diminuição da dor, do estresse e melhora no desempenho cognitivo. Este estudo irá colaborar para a definição de um protocolo de neuromodulação mais adequado, contribuindo para a tomada de decisão clínica na MC.Research, Society and Development2020-07-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/576810.33448/rsd-v9i8.5768Research, Society and Development; Vol. 9 No. 8; e562985768Research, Society and Development; Vol. 9 Núm. 8; e562985768Research, Society and Development; v. 9 n. 8; e5629857682525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/5768/5160Copyright (c) 2020 Renata Emanuela Lyra de Brito Aranha, Nelson Torro, Suellen Marinho de Andrade, Bernardino Fernández-Calvo, Eliane Araújo de Oliveirahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAranha, Renata Emanuela Lyra de BritoTorro, NelsonAndrade, Suellen Marinho deFernández-Calvo, BernardinoOliveira, Eliane Araújo de2020-08-20T18:00:17Zoai:ojs.pkp.sfu.ca:article/5768Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:10.734311Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
Comparación entre protocolos de Estimulación Transcraneal de Corriente Contínua em la Migraña Crónica (NEUROMIG)
Comparação entre protocolos de Estimulação Transcraniana por Corrente Contínua na Migrânea Crônica (NEUROMIG)
title Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
spellingShingle Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
Aranha, Renata Emanuela Lyra de Brito
Estimulação transcraniana por corrente contínua
Testes neuropsicológicos
Transtornos de enxaqueca
Dor.
Estimulación transcraneal de corriente continua
Pruebas neuropsicológicas
Trastornos de migraña
Dolor.
Transcranial direct current stimulation
Neuropsychological tests
Migraine disorders
Pain.
title_short Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
title_full Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
title_fullStr Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
title_full_unstemmed Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
title_sort Comparison between Transcranial Direct Current Stimulation protocols in Chronic Migraine (NEUROMIG)
author Aranha, Renata Emanuela Lyra de Brito
author_facet Aranha, Renata Emanuela Lyra de Brito
Torro, Nelson
Andrade, Suellen Marinho de
Fernández-Calvo, Bernardino
Oliveira, Eliane Araújo de
author_role author
author2 Torro, Nelson
Andrade, Suellen Marinho de
Fernández-Calvo, Bernardino
Oliveira, Eliane Araújo de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Aranha, Renata Emanuela Lyra de Brito
Torro, Nelson
Andrade, Suellen Marinho de
Fernández-Calvo, Bernardino
Oliveira, Eliane Araújo de
dc.subject.por.fl_str_mv Estimulação transcraniana por corrente contínua
Testes neuropsicológicos
Transtornos de enxaqueca
Dor.
Estimulación transcraneal de corriente continua
Pruebas neuropsicológicas
Trastornos de migraña
Dolor.
Transcranial direct current stimulation
Neuropsychological tests
Migraine disorders
Pain.
topic Estimulação transcraniana por corrente contínua
Testes neuropsicológicos
Transtornos de enxaqueca
Dor.
Estimulación transcraneal de corriente continua
Pruebas neuropsicológicas
Trastornos de migraña
Dolor.
Transcranial direct current stimulation
Neuropsychological tests
Migraine disorders
Pain.
description Chronic migraine (CM) has a wide range of symptoms, with debilitating consequences for those individuals refractory to the conventional treatments. In this context, Transcranial Direct Current Stimulation (tDCS) is a promising technique, although there is still no consensus on the most appropriate protocol, which may vary in relation to the number and interval between the application sessions. The present work consists of a protocol to assess the clinical and cognitive effects of ETCC on CM in the form of a double-blind, randomized and placebo-controlled clinical trial. The sample will consist of women aged between 20 and 45 years with a diagnosis of CM. A sociodemographic questionnaire and instruments for assessing cognitive functions, affective aspects, and clinical evaluation of migraine will be applied. Participants will be randomly distributed among 3 groups: Group 1: will receive a daily tDCS session for 15 minutes; Group 2: will receive two daily tDCS sessions of 15 minutes, with an interval of 20 minutes between them; Group 3: will receive simulated stimulation (sham) for 15 minutes. The anode electrode will be placed on the left dorsolateral prefrontal cortex and the reference electrode on the contralateral supraorbital region. In the Groups 1 and 2 the current will have an intensity of 2mA and will be applied for 10 consecutive days. We expect that tDCS will be effective in reducing symptoms in CM, with a decreased in pain and stress, and an improvement in the cognitive performance. This study will help to define a more appropriate neuromodulation protocol, contributing to the clinical decision making in CM.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/5768
10.33448/rsd-v9i8.5768
url https://rsdjournal.org/index.php/rsd/article/view/5768
identifier_str_mv 10.33448/rsd-v9i8.5768
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/5768/5160
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 8; e562985768
Research, Society and Development; Vol. 9 Núm. 8; e562985768
Research, Society and Development; v. 9 n. 8; e562985768
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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