Genetic bases related to the development of non-syndromic dental agenesis: a literature review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/9882 |
Resumo: | Non-syndromic dental agenesis is characterized as the most common developmental anomaly in humans, causing the lack of one or more teeth, in deciduous or permanent dentition. Mutations in specific genes of dental development are pointed as etiological factors of this anomaly. To perform this work, two electronic databases were consulted to conduct a literature survey, including PubMed and BVS. The descriptor "Anodontia" was used in both. The articles were filtered from 2010 to 2020, including full texts, in english, portuguese and spanish. Dissertations, theses and book chapters were discarded. In PubMed, from 508 articles found, 13 were included for review. In the BVS, from 304 articles found, 07 were included for review, totaling 20 articles. Studies have shown that mutations by nucleotide subitusing and deletion were more present in genes that cause dental agenesis (PAX9, MSX1, AXIN2, WNT). In epidemiologic studies, women showed greater involvement than men, both in deciduous and permanent dentition, in a ratio of 3:2. In addition, leukoderms showed greater involvement than melanoderms. Knowledge of the genotype-phenotype correlation between mutations and dental agenesis is important for the dental surgeon, as it assists in diagnosis, genetic counseling, treatment and prognosis. |
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Genetic bases related to the development of non-syndromic dental agenesis: a literature review Bases genéticas relacionadas con el desarrollo de agenesia dental no sindrómica: revisión de literaturaBases genéticas relacionadas ao desenvolvimento de agenesia dentária não sindrômica: uma revisão de literaturaGenética Mutação Anomalia dentária. GenéticaMutación Anomalía dental.Genetics Mutation Dental anomaly.Non-syndromic dental agenesis is characterized as the most common developmental anomaly in humans, causing the lack of one or more teeth, in deciduous or permanent dentition. Mutations in specific genes of dental development are pointed as etiological factors of this anomaly. To perform this work, two electronic databases were consulted to conduct a literature survey, including PubMed and BVS. The descriptor "Anodontia" was used in both. The articles were filtered from 2010 to 2020, including full texts, in english, portuguese and spanish. Dissertations, theses and book chapters were discarded. In PubMed, from 508 articles found, 13 were included for review. In the BVS, from 304 articles found, 07 were included for review, totaling 20 articles. Studies have shown that mutations by nucleotide subitusing and deletion were more present in genes that cause dental agenesis (PAX9, MSX1, AXIN2, WNT). In epidemiologic studies, women showed greater involvement than men, both in deciduous and permanent dentition, in a ratio of 3:2. In addition, leukoderms showed greater involvement than melanoderms. Knowledge of the genotype-phenotype correlation between mutations and dental agenesis is important for the dental surgeon, as it assists in diagnosis, genetic counseling, treatment and prognosis. La agenesia dental no sindrómica se caracteriza como la anomalía del desarrollo más común en los seres humanos, causando la falta de uno o más dientes, en la dentición primaria o permanente. Las mutaciones en genes específicos del desarrollo dental se señalan como factores etiológicos de esta anomalía. Para llevar a cabo este trabajo, se consultaron dos bases de datos electrónicas para llevar a cabo una encuesta de literatura, incluyendo PubMed y BVS. El descriptor "Anodontia" se utilizó en ambos. Los artículos se filtraron de 2010 a 2020, incluyendo textos completos, en inglés, portugués y español. Se descartaron disertaciones, tesis y capítulos de libros. En el PubMed de 508 artículos encontrados, 13 fueron incluidos para su revisión. En el BVS de 304 artículos encontrados, 07 fueron incluidos para la revisión, con un total de 20 artículos. Los estudios han demostrado que las mutaciones por nucleótido sulis y la deleción estaban más presentes en los genes causantes de la agenesia (PAX9, MSX1, AXIN2, WNT). En estudios epidemiológicos, las mujeres mostraron una mayor implicación que los hombres, tanto en la dentición primaria y permanente, en una proporción de 3:2. Además, leucodermos mostraron una mayor implicación que melanoderms. El conocimiento de la correlación genotipo-fenotipo entre mutaciones y agenesia dental es importante para el dentista, ya que ayuda en el diagnóstico, asesoramiento genético, tratamiento y pronóstico. A agenesia dentária não sindrômica se caracteriza como a anomalia de desenvolvimento mais comum nos seres humanos, ocasionando a falta de um ou mais dentes, na dentição decídua ou permanente. Mutações em genes específicos do desenvolvimento dentário são apontadas como fatores etiológicos desta anomalia. Para a realização deste trabalho duas bases de dados eletrônicas foram consultadas para fazer um levantamento de literatura, sendo elas: PubMed e BVS. Em ambas utilizou-se o descritor “Anodontia”. Os artigos foram filtrados no período de 2010 a 2020, incluindo textos completos, em idioma inglês, português e espanhol. Descartaram-se dissertações, teses e capítulos de livros. No PubMed, de 508 artigos encontrados, 13 foram incluídos para a revisão. Na BVS, de 304 artigos encontrados, 07 foram incluídos para a revisão, totalizando 20 artigos. Os estudos demonstraram que mutações por substituição de nucleotideo e deleção mostraram-se mais presentes nos genes causadores da agenesia (PAX9, MSX1, AXIN2, WNT). Nos estudos epidemiologicos as mulheres mostraram maior acometimento que os homens, tanto na dentição decidua quanto na permanente, com uma proporção de 3:2. Além disso, os leucodermas apresentaram maior acometimento que os melanodermas. O conhecimento da correlação genótipo-fenótipo entre mutações e agenesia dentária é importante para o cirurgião dentista, pois auxilia no diagnóstico, aconselhamento genético, tratamento e prognóstico. Research, Society and Development2020-11-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/988210.33448/rsd-v9i11.9882Research, Society and Development; Vol. 9 No. 11; e2449119882Research, Society and Development; Vol. 9 Núm. 11; e2449119882Research, Society and Development; v. 9 n. 11; e24491198822525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/9882/8661Copyright (c) 2020 Iago Demétrio da Silva; Caio Cesar Santos Patron Luiz ; Andressa Bolognesi Bachesk ; Brenda da Silva Balassa https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Iago Demétrio da Luiz , Caio Cesar Santos Patron Bachesk , Andressa Bolognesi Balassa , Brenda da Silva 2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/9882Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:03.706534Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review Bases genéticas relacionadas con el desarrollo de agenesia dental no sindrómica: revisión de literatura Bases genéticas relacionadas ao desenvolvimento de agenesia dentária não sindrômica: uma revisão de literatura |
title |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
spellingShingle |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review Silva, Iago Demétrio da Genética Mutação Anomalia dentária. Genética Mutación Anomalía dental. Genetics Mutation Dental anomaly. |
title_short |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
title_full |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
title_fullStr |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
title_full_unstemmed |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
title_sort |
Genetic bases related to the development of non-syndromic dental agenesis: a literature review |
author |
Silva, Iago Demétrio da |
author_facet |
Silva, Iago Demétrio da Luiz , Caio Cesar Santos Patron Bachesk , Andressa Bolognesi Balassa , Brenda da Silva |
author_role |
author |
author2 |
Luiz , Caio Cesar Santos Patron Bachesk , Andressa Bolognesi Balassa , Brenda da Silva |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Iago Demétrio da Luiz , Caio Cesar Santos Patron Bachesk , Andressa Bolognesi Balassa , Brenda da Silva |
dc.subject.por.fl_str_mv |
Genética Mutação Anomalia dentária. Genética Mutación Anomalía dental. Genetics Mutation Dental anomaly. |
topic |
Genética Mutação Anomalia dentária. Genética Mutación Anomalía dental. Genetics Mutation Dental anomaly. |
description |
Non-syndromic dental agenesis is characterized as the most common developmental anomaly in humans, causing the lack of one or more teeth, in deciduous or permanent dentition. Mutations in specific genes of dental development are pointed as etiological factors of this anomaly. To perform this work, two electronic databases were consulted to conduct a literature survey, including PubMed and BVS. The descriptor "Anodontia" was used in both. The articles were filtered from 2010 to 2020, including full texts, in english, portuguese and spanish. Dissertations, theses and book chapters were discarded. In PubMed, from 508 articles found, 13 were included for review. In the BVS, from 304 articles found, 07 were included for review, totaling 20 articles. Studies have shown that mutations by nucleotide subitusing and deletion were more present in genes that cause dental agenesis (PAX9, MSX1, AXIN2, WNT). In epidemiologic studies, women showed greater involvement than men, both in deciduous and permanent dentition, in a ratio of 3:2. In addition, leukoderms showed greater involvement than melanoderms. Knowledge of the genotype-phenotype correlation between mutations and dental agenesis is important for the dental surgeon, as it assists in diagnosis, genetic counseling, treatment and prognosis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9882 10.33448/rsd-v9i11.9882 |
url |
https://rsdjournal.org/index.php/rsd/article/view/9882 |
identifier_str_mv |
10.33448/rsd-v9i11.9882 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9882/8661 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 11; e2449119882 Research, Society and Development; Vol. 9 Núm. 11; e2449119882 Research, Society and Development; v. 9 n. 11; e2449119882 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052663475470336 |