Intestinal dysbiosis in obese: Literature review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40980 |
Resumo: | Obesity is characterized by the excess of adipose tissue in the individual's body composition, resulting from a caloric intake greater than energy expenditure combined with multifactors, especially genetics, the environment and sedentary behavior. The eating habits of a western diet (foods rich in saturated fats, refined sugars and low fiber and polyphenol intake) influence the lower diversity of the phylum Bacterioidetes, characterizing the condition of intestinal dysbiosis. This narrative review article aimed to describe the relationship between obesity and dysbiosis, and reporting some metabolic aspects of obesity, emphasizing changes in the intestinal microbiota. Intestinal dysbiosis allied to poor eating habits weakens the junction of firmly adherent cells in the intestine, causing greater intestinal permeability that results in low-grade systemic inflammation due to the recruitment of immune cells and the increase of inflammatory proteins [factor of tumor necrosis (TNF-α), interleukin 6 (IL-6)] and reactive oxygen species (ROS), due to translocation of gram-negative bacteria and their toxic metabolites known as lipopolysaccharides (LPS) into the serum. A lower microbial diversity among the phyla characterizing intestinal dysbiosis. As a result, some treatments such as the use of prebiotics and probiotics combined with a balanced diet rich in whole grains, low in refined sugars and saturated fatty acids can increase the diversity of the microbiome reducing these inflammatory markers, and improving important biochemical parameters with o blood glucose and serum triglycerides. |
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Intestinal dysbiosis in obese: Literature reviewDisbiosis intestinal en obesos: Una revisión de la literaturaDisbiose intestinal em obesos: Uma revisão de literatura MicrobiomePrebioticsObesityDysbiosis.MicrobiomaPrebióticosObesidadDisbiosis.MicrobiomaPrebióticosObesidadeDisbiose.Obesity is characterized by the excess of adipose tissue in the individual's body composition, resulting from a caloric intake greater than energy expenditure combined with multifactors, especially genetics, the environment and sedentary behavior. The eating habits of a western diet (foods rich in saturated fats, refined sugars and low fiber and polyphenol intake) influence the lower diversity of the phylum Bacterioidetes, characterizing the condition of intestinal dysbiosis. This narrative review article aimed to describe the relationship between obesity and dysbiosis, and reporting some metabolic aspects of obesity, emphasizing changes in the intestinal microbiota. Intestinal dysbiosis allied to poor eating habits weakens the junction of firmly adherent cells in the intestine, causing greater intestinal permeability that results in low-grade systemic inflammation due to the recruitment of immune cells and the increase of inflammatory proteins [factor of tumor necrosis (TNF-α), interleukin 6 (IL-6)] and reactive oxygen species (ROS), due to translocation of gram-negative bacteria and their toxic metabolites known as lipopolysaccharides (LPS) into the serum. A lower microbial diversity among the phyla characterizing intestinal dysbiosis. As a result, some treatments such as the use of prebiotics and probiotics combined with a balanced diet rich in whole grains, low in refined sugars and saturated fatty acids can increase the diversity of the microbiome reducing these inflammatory markers, and improving important biochemical parameters with o blood glucose and serum triglycerides.La obesidad se caracteriza por el exceso de tejido adiposo en la composición corporal del individuo, como resultado de una ingesta calórica superior al gasto energético combinado con multifactores, especialmente la genética, el medio ambiente y el sedentarismo. Los hábitos alimentarios de una dieta occidental (alimentos ricos en grasas saturadas, azúcares refinados y bajo aporte de fibra y polifenoles) influyen en la menor diversidad del phylum Bacterioidetes, caracterizando el cuadro de disbiosis intestinal. Este artículo de revisión narrativa tuvo como objetivo describir la relación entre la obesidad y la disbiosis, relatando algunos aspectos metabólicos de la obesidad, e enfatizando cambios en la microbiota intestinal. La disbiosis intestinal aliada a malos hábitos alimentarios debilita la unión de células firmemente adheridas en el intestino, provocando una mayor permeabilidad intestinal que se traduce en una inflamación sistémica de bajo grado por el reclutamiento de células inmunes y el aumento de proteínas inflamatorias [factor de necrosis tumoral (TNF) -α), interleucina 6 (IL-6)] y especies reactivas de oxígeno (ROS), debido a la translocación de bacterias gramnegativas y sus metabolitos tóxicos conocidos como lipopolisacáridos (LPS) en el suero. Una menor diversidad microbiana entre los filos que caracteriza la disbiosis intestinal Como resultado, algunos tratamientos como el uso de prebióticos y probióticos combinados con una dieta equilibrada rica en cereales integrales, baja en azúcares refinados y ácidos grasos saturados pueden aumentar la diversidad del microbioma reduciendo estos marcadores inflamatorios y mejorando parámetros bioquímicos importantes con o glucosa en sangre y triglicéridos séricos.A obesidade é caracterizada pelo excedente de tecido adiposo na composição corporal do indivíduo, proveniente de uma ingesta calórica superior ao gasto energético aliado a multifatores com destaque para a genética, o ambiente e o comportamento sedentário. Os hábitos alimentares de uma dieta ocidental (alimentos ricos em gorduras saturadas, açúcares refinados e baixa ingestão de fibras e polifenóis) exerce influência na menor diversidade do filo bacterioidetes, caracterizando o quadro de disbiose intestinal. Este artigo de revisão narrativa teve como objetivo descrever a relação da obesidade com a disbiose relatando alguns aspectos metabólicos da obesidade, e enfatizando as alterações na microbiota intestinal. A disbiose intestinal aliada aos maus hábitos alimentares propicia o enfraquecimento da junção das células de adesão firme no intestino, provocando uma maior permeabilidade intestinal resultante em uma inflamação sistêmica de baixo grau devido ao recrutamento de células imunológicas e o aumento de proteínas inflamatórias [fator de necrose tumoral (TNF-α), interleucina 6 (IL-6)] e espécies reativas de oxigênio (ROS), devido à translocação de bactérias gram-negativas e seus metabólitos tóxicos conhecidos como lipopolissacarídeos (LPS) para a corrente sérica. Em obesos é comum uma menor diversidade microbiana entre os filos caracterizando a disbiose intestinal. Em virtude disso, alguns tratamentos como o emprego de prebióticos e probióticos aliado a uma alimentação balanceada rica em grãos integrais, pobre em açúcares refinados e ácidos graxos saturados pode propiciar o aumento da diversidade do microbioma reduzindo esses marcadores infamatórios, e melhorando parâmetros bioquímicos importantes como a glicemia e os triglicerídeos séricos.Research, Society and Development2023-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4098010.33448/rsd-v12i4.40980Research, Society and Development; Vol. 12 No. 4; e9712440980Research, Society and Development; Vol. 12 Núm. 4; e9712440980Research, Society and Development; v. 12 n. 4; e97124409802525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/40980/33408Copyright (c) 2023 Lucas Inácio de Loyola Vinha; Martha Elisa Ferreira de Almeida; Beatriz Barakat ; Bianca Ferreira de Santana; Madalena Geralda Cupertino Ribeiro; Gabrielly Senna Parussolohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVinha, Lucas Inácio de Loyola Almeida, Martha Elisa Ferreira de Barakat , BeatrizSantana, Bianca Ferreira de Ribeiro, Madalena Geralda Cupertino Parussolo, Gabrielly Senna 2023-04-21T18:13:32Zoai:ojs.pkp.sfu.ca:article/40980Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-04-21T18:13:32Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Intestinal dysbiosis in obese: Literature review Disbiosis intestinal en obesos: Una revisión de la literatura Disbiose intestinal em obesos: Uma revisão de literatura |
title |
Intestinal dysbiosis in obese: Literature review |
spellingShingle |
Intestinal dysbiosis in obese: Literature review Vinha, Lucas Inácio de Loyola Microbiome Prebiotics Obesity Dysbiosis. Microbioma Prebióticos Obesidad Disbiosis. Microbioma Prebióticos Obesidade Disbiose. |
title_short |
Intestinal dysbiosis in obese: Literature review |
title_full |
Intestinal dysbiosis in obese: Literature review |
title_fullStr |
Intestinal dysbiosis in obese: Literature review |
title_full_unstemmed |
Intestinal dysbiosis in obese: Literature review |
title_sort |
Intestinal dysbiosis in obese: Literature review |
author |
Vinha, Lucas Inácio de Loyola |
author_facet |
Vinha, Lucas Inácio de Loyola Almeida, Martha Elisa Ferreira de Barakat , Beatriz Santana, Bianca Ferreira de Ribeiro, Madalena Geralda Cupertino Parussolo, Gabrielly Senna |
author_role |
author |
author2 |
Almeida, Martha Elisa Ferreira de Barakat , Beatriz Santana, Bianca Ferreira de Ribeiro, Madalena Geralda Cupertino Parussolo, Gabrielly Senna |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vinha, Lucas Inácio de Loyola Almeida, Martha Elisa Ferreira de Barakat , Beatriz Santana, Bianca Ferreira de Ribeiro, Madalena Geralda Cupertino Parussolo, Gabrielly Senna |
dc.subject.por.fl_str_mv |
Microbiome Prebiotics Obesity Dysbiosis. Microbioma Prebióticos Obesidad Disbiosis. Microbioma Prebióticos Obesidade Disbiose. |
topic |
Microbiome Prebiotics Obesity Dysbiosis. Microbioma Prebióticos Obesidad Disbiosis. Microbioma Prebióticos Obesidade Disbiose. |
description |
Obesity is characterized by the excess of adipose tissue in the individual's body composition, resulting from a caloric intake greater than energy expenditure combined with multifactors, especially genetics, the environment and sedentary behavior. The eating habits of a western diet (foods rich in saturated fats, refined sugars and low fiber and polyphenol intake) influence the lower diversity of the phylum Bacterioidetes, characterizing the condition of intestinal dysbiosis. This narrative review article aimed to describe the relationship between obesity and dysbiosis, and reporting some metabolic aspects of obesity, emphasizing changes in the intestinal microbiota. Intestinal dysbiosis allied to poor eating habits weakens the junction of firmly adherent cells in the intestine, causing greater intestinal permeability that results in low-grade systemic inflammation due to the recruitment of immune cells and the increase of inflammatory proteins [factor of tumor necrosis (TNF-α), interleukin 6 (IL-6)] and reactive oxygen species (ROS), due to translocation of gram-negative bacteria and their toxic metabolites known as lipopolysaccharides (LPS) into the serum. A lower microbial diversity among the phyla characterizing intestinal dysbiosis. As a result, some treatments such as the use of prebiotics and probiotics combined with a balanced diet rich in whole grains, low in refined sugars and saturated fatty acids can increase the diversity of the microbiome reducing these inflammatory markers, and improving important biochemical parameters with o blood glucose and serum triglycerides. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40980 10.33448/rsd-v12i4.40980 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40980 |
identifier_str_mv |
10.33448/rsd-v12i4.40980 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40980/33408 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 4; e9712440980 Research, Society and Development; Vol. 12 Núm. 4; e9712440980 Research, Society and Development; v. 12 n. 4; e9712440980 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052621477904384 |