Relationship inflammatory cytokine and CRP and cardiovascular risk in patients with Crohn's disease

• Autor(a) principal: Dias, Thaline Milany da Silva
• Data de Publicação: 2021
• Outros Autores: Cardoso, Bruna Emanuele Pereira, Silva, Ayres Fran da Silva e, Silva, Rafaelly Raiane Soares da, Freitas, Taynáh Emannuelle Coelho de, Severo, Juliana Soares, Cardoso, Guida Graziela Santos, Milanez, Letícia de Sousa, Moura, Alana Rafaela da Silva, Morais, Jennifer Beatriz Silva
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14088
• topic: Inflammation; Crohn disease; Cardiovascular diseases; C-Reactive protein.; Inflamación; Enfermedad de Crohn; Enfermedades cardiovasculares; Proteína C-reactiva.; Inflamação; Doença de Crohn; Doenças cardiovasculares; Proteína C-Reativa.

Objective: To investigate and correlate the level of CRP and pro-inflammatory cytokines as signs of inflammation and to verify cardiovascular risk in patients with Crohn's disease. Methods: The study was composed of 36 patients (18 control and 18 case) Results: The analyzes showed serum levels of CRP, IL-10, IFN-γ, IL-8, TNF-α higher in patients with the disease when compared to control group, with significant difference in relation to CRP. It was observed that the mean of 131.12, total cholesterol, 40.85, HDL-c and 76.05, LDL-c for the case group Conclusions: Higher CRP and cytokine levels in the case group suggests that patients with Crohn's disease has increased cardiovascular risk when compared to people without the disease and other risk factors.