In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia

Detalhes bibliográficos
Autor(a) principal: Nascimento, Daniela Macedo
Data de Publicação: 2022
Outros Autores: Nascimento, Ademir Macedo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/24393
Resumo: The In Silico technique selects and optimizes the choice of the best processes in a matrix of interest, while the In Vitro study is performed in Petri dishes with cell cultures. The In Vivo study provides the measurement of the effects of the species to be studied. In this case, the alkaloid will be injected both in cell cultures and in in vivo studies, to indicate toxicity, efficiency and its subsequent effects. Alkaloids or other types of compounds that generate drugs will be analyzed. Alkaloids are secondary metabolites that are characterized by being a cyclic structure with nitrogen and free electrons, being very reactive and presenting applications in the pharmaceutical and medicinal areas. Giardia Lamblia is a pathogenic protozoan whose transmission is through contaminated water and food, being responsible for the disease giardiasis, which has some symptoms such as abdominal pain, diarrhea and causes millions of deaths per year worldwide.
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spelling In vitro, in vivo and in sílico studies of alkaloids against Giardia LambliaEstudios in vitro, in vivo e in silico de alcalóides contra Giardia LambliaEstudos in vitro, in vivo e in sílico de alcaloides frente a Giardia LâmbliaIn silicoIn vivoIn vitroAlcaloideGiardia lamblia.In silicoIn vivoIn vitroAlcalóideGiardia lamblia.In silicoIn vivoIn vitroAlkaloidGiardia lamblia.The In Silico technique selects and optimizes the choice of the best processes in a matrix of interest, while the In Vitro study is performed in Petri dishes with cell cultures. The In Vivo study provides the measurement of the effects of the species to be studied. In this case, the alkaloid will be injected both in cell cultures and in in vivo studies, to indicate toxicity, efficiency and its subsequent effects. Alkaloids or other types of compounds that generate drugs will be analyzed. Alkaloids are secondary metabolites that are characterized by being a cyclic structure with nitrogen and free electrons, being very reactive and presenting applications in the pharmaceutical and medicinal areas. Giardia Lamblia is a pathogenic protozoan whose transmission is through contaminated water and food, being responsible for the disease giardiasis, which has some symptoms such as abdominal pain, diarrhea and causes millions of deaths per year worldwide.La técnica In Silico selecciona y optimiza la elección de los mejores procesos en una matriz de interés, mientras que el estudio In Vitro se realiza en placas Petri con cultivos celulares. El estudio In Vivo proporciona la medición de los efectos de las especies a estudiar. En este caso, el alcaloide se inyectará tanto en cultivos celulares como en estudios in vivo, para indicar toxicidad, eficacia y sus efectos posteriores. Se analizarán alcaloides u otro tipo de compuestos que generen drogas. Los alcaloides son metabolitos secundarios que se caracterizan por ser una estructura cíclica con nitrógeno y electrones libres, siendo muy reactivos y presentando aplicaciones en las áreas farmacéutica y medicinal. Giardia Lamblia es un protozoario patógeno cuya transmisión es a través de agua y alimentos contaminados, siendo el responsable de la enfermedad giardiasis, que presenta algunos síntomas como dolor abdominal, diarrea y causa millones de muertes al año en todo el mundo.A técnica In Silico seleciona e otimiza a escolha dos melhores processos em uma matriz de interesse, já o estudo In Vitro é realizado em placas de Petri com culturas celulares. O estudo In Vivo proporciona  mensurar os efeitos da espécie a ser estudada. Neste caso, o alcalóide será injetado tanto nas culturas celulares como nos estudos in vivo, para indicar toxicidade, eficiência e seus efeitos posteriores. Serão analisados alcalóides ou outros tipos de compostos que geram fármacos. Os alcalóides são metabólitos secundários que se caracterizam por serem uma estrutura cíclica com nitrogênio e par de elétrons livres, sendo muito reativos e apresentando aplicações nas áreas farmacêuticas e medicinais. A Giárdia Lamblia é um protozoário patogênico cuja transmissão é por intermédio de água e alimentos contaminados, sendo responsável pela doença giardíase, que apresenta alguns sintomas como dores abdominais, diarreia e causa milhões de mortes por ano em todo o mundo.Research, Society and Development2022-03-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2439310.33448/rsd-v11i3.24393Research, Society and Development; Vol. 11 No. 3; e57811324393Research, Society and Development; Vol. 11 Núm. 3; e57811324393Research, Society and Development; v. 11 n. 3; e578113243932525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/24393/23589Copyright (c) 2022 Daniela Macedo Nascimento; Ademir Macedo Nascimentohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNascimento, Daniela Macedo Nascimento, Ademir Macedo 2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/24393Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:57.975150Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
Estudios in vitro, in vivo e in silico de alcalóides contra Giardia Lamblia
Estudos in vitro, in vivo e in sílico de alcaloides frente a Giardia Lâmblia
title In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
spellingShingle In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
Nascimento, Daniela Macedo
In silico
In vivo
In vitro
Alcaloide
Giardia lamblia.
In silico
In vivo
In vitro
Alcalóide
Giardia lamblia.
In silico
In vivo
In vitro
Alkaloid
Giardia lamblia.
title_short In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
title_full In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
title_fullStr In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
title_full_unstemmed In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
title_sort In vitro, in vivo and in sílico studies of alkaloids against Giardia Lamblia
author Nascimento, Daniela Macedo
author_facet Nascimento, Daniela Macedo
Nascimento, Ademir Macedo
author_role author
author2 Nascimento, Ademir Macedo
author2_role author
dc.contributor.author.fl_str_mv Nascimento, Daniela Macedo
Nascimento, Ademir Macedo
dc.subject.por.fl_str_mv In silico
In vivo
In vitro
Alcaloide
Giardia lamblia.
In silico
In vivo
In vitro
Alcalóide
Giardia lamblia.
In silico
In vivo
In vitro
Alkaloid
Giardia lamblia.
topic In silico
In vivo
In vitro
Alcaloide
Giardia lamblia.
In silico
In vivo
In vitro
Alcalóide
Giardia lamblia.
In silico
In vivo
In vitro
Alkaloid
Giardia lamblia.
description The In Silico technique selects and optimizes the choice of the best processes in a matrix of interest, while the In Vitro study is performed in Petri dishes with cell cultures. The In Vivo study provides the measurement of the effects of the species to be studied. In this case, the alkaloid will be injected both in cell cultures and in in vivo studies, to indicate toxicity, efficiency and its subsequent effects. Alkaloids or other types of compounds that generate drugs will be analyzed. Alkaloids are secondary metabolites that are characterized by being a cyclic structure with nitrogen and free electrons, being very reactive and presenting applications in the pharmaceutical and medicinal areas. Giardia Lamblia is a pathogenic protozoan whose transmission is through contaminated water and food, being responsible for the disease giardiasis, which has some symptoms such as abdominal pain, diarrhea and causes millions of deaths per year worldwide.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24393
10.33448/rsd-v11i3.24393
url https://rsdjournal.org/index.php/rsd/article/view/24393
identifier_str_mv 10.33448/rsd-v11i3.24393
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24393/23589
dc.rights.driver.fl_str_mv Copyright (c) 2022 Daniela Macedo Nascimento; Ademir Macedo Nascimento
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Daniela Macedo Nascimento; Ademir Macedo Nascimento
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 3; e57811324393
Research, Society and Development; Vol. 11 Núm. 3; e57811324393
Research, Society and Development; v. 11 n. 3; e57811324393
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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