The effectiveness of convalescent plasma in the treatment of COVID-19: a systematic review

• Autor(a) principal: Santos, Marcia Rodrigues dos
• Data de Publicação: 2022
• Outros Autores: Bridi, Adriana Carla, Louro, Thiago Quinellato, Carvalho, Márglory Fraga de, Carvalho, Tatiana Santos de, Silva, Roberto Carlos Lyra da, Silva, Carlos Roberto Lyra da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26877
• topic: COVID-19; Convalescent plasma; SARS-CoV-2.; COVID-19; Plasma convaleciente; SARS-CoV-2.; COVID-19; Plasma convalescente; SARS-CoV-2.

The aim of this review was to analyze the therapeutic effectiveness of convalescent plasma used in patients with diagnosis confirmed of COVID-19. Methods: This is a systematic literature review propose in the Cochrane Collaboration Manual, with the elaboration of the PICO strategy, in which the Pubmed/Medline, BVS, Embase, CINAHL, LILACS, Cochrane and Google Scholar databases were used. Randomized clinical trials and systematic reviews were selected. We found 1249 articles, applying the inclusion and exclusion criteria, 8 articles were selected. AMSTAR-2 was used to assess the risk of bias and the quality of the evidence from the studies included in the systematic review was evaluated by the Grading of Recommendations Assessment Development and Evaluation (GRADE). Results: Regarding the results, studies with a low level of Oxford evidence predominated (75%). Four studies (50%) showed evidence level 2B. However, one response to this analysis was the low quality of the evidence and little confidence in the results of the studies. The qualitative synthesis revealed that although it was able to reduce the viral load, the use of convalescent plasma does not contribute in isolation to the reduction of the load. Conclusion: It is concluded that convalescent plasma is effective for reducing viral load and that many studies are still lacking, particularly economic analysis of effectiveness, as it is a cheap technology with potential for incorporation into the SUS.