Multirresistant bacteria and their impacts on public health: A social responsability
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/16303 |
Resumo: | Introduction: Human beings coexist with numerous bacteria, but pathogenic species have plagued mankind for millennia until the advent of the first antibiotics. However, the indiscriminate use of antibiotics, both in hospitals and in agriculture, has generated high rates of bacterial resistance and has become a problem with imminent disruption. The present study aims to analyze the multifactorial etiology of bacterial multiresistance mechanisms, the prevalence of the main bacteria involved in this process and its impact on public health. Methodology: This is an integrative literature review about the processes and consequences of bacterial resistance. The inclusion criterion was compatibility with the theme and relevance. Results: 46 articles were analyzed, half of which are original articles. Among these, 6 articles carried out a survey of the prevalence of pharmacoresistant bacteria in nosocomial environments, with a sample of 646 patients in which Klebsiella pneumoniae was isolated in 27.11%, Pseudomonas aeruginosa in 19%, followed by Escherichia coli with 16%, and Staphylococcus aureus with 4.75%. Discussion: With 25 to 50% of antibiotic administrations in hospitals considered irregular, their indiscriminate use and the slow formulation of new therapeutic options, among others, contributed to the development of multidrug-resistant bacterial strains during the antimicrobial era. The main pharmacoresistance mechanisms include antibiotic modification; preventing the action of the antibiotic on its target; alteration of the primary binding site; and producing an alternative target to circumvent the drug's effect. Final Considerations: Bacterial multidrug resistance increases morbidity and mortality, length of hospital stay and expenses with supplies and specialized staff. It was established as a problem that tends to worsen over time, therefore, comprehensive studies focused on bacterial prevalence are necessary to outline public health strategies aimed at its control. |
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Multirresistant bacteria and their impacts on public health: A social responsabilityBacterias multirresistentes y sus impactos en la salud pública: Una responsabilidade socialBactérias multirresistentes e seus impactos na saúde pública: Uma responsabilidade socialBacterial Drug ResistanceBacterial InfectionsPublic health.Farmacorresistencia bacterianaInfecciones bacterianasSalud pública.Farmacorresistência BacterianaInfecções BacterianasSaúde pública.Introduction: Human beings coexist with numerous bacteria, but pathogenic species have plagued mankind for millennia until the advent of the first antibiotics. However, the indiscriminate use of antibiotics, both in hospitals and in agriculture, has generated high rates of bacterial resistance and has become a problem with imminent disruption. The present study aims to analyze the multifactorial etiology of bacterial multiresistance mechanisms, the prevalence of the main bacteria involved in this process and its impact on public health. Methodology: This is an integrative literature review about the processes and consequences of bacterial resistance. The inclusion criterion was compatibility with the theme and relevance. Results: 46 articles were analyzed, half of which are original articles. Among these, 6 articles carried out a survey of the prevalence of pharmacoresistant bacteria in nosocomial environments, with a sample of 646 patients in which Klebsiella pneumoniae was isolated in 27.11%, Pseudomonas aeruginosa in 19%, followed by Escherichia coli with 16%, and Staphylococcus aureus with 4.75%. Discussion: With 25 to 50% of antibiotic administrations in hospitals considered irregular, their indiscriminate use and the slow formulation of new therapeutic options, among others, contributed to the development of multidrug-resistant bacterial strains during the antimicrobial era. The main pharmacoresistance mechanisms include antibiotic modification; preventing the action of the antibiotic on its target; alteration of the primary binding site; and producing an alternative target to circumvent the drug's effect. Final Considerations: Bacterial multidrug resistance increases morbidity and mortality, length of hospital stay and expenses with supplies and specialized staff. It was established as a problem that tends to worsen over time, therefore, comprehensive studies focused on bacterial prevalence are necessary to outline public health strategies aimed at its control.Introducción: Los seres humanos coexisten con numerosas bacterias, pero las especies patógenas han plagado a la humanidad durante milenios hasta la llegada de los primeros antibióticos. Sin embargo, el uso indiscriminado de antibióticos, tanto en hospitales como en agricultura, ha generado altas tasas de resistencia bacteriana y se ha convertido en un problema de disrupción inminente. Este estudio tiene como objetivo analizar la etiología multifactorial de los mecanismos de multirresistencia bacteriana, la prevalencia de las principales bacterias involucradas en este proceso y su impacto en la salud pública. Metodología: Se trata de una revisión integradora de la literatura sobre los procesos y consecuencias de la resistencia bacteriana. El criterio de inclusión fue la compatibilidad con el tema y la relevancia. Resultados: se analizaron 46 artículos, la mitad de los cuales son originales. Entre estos, 6 artículos realizaron una encuesta de prevalencia de bacterias farmacorresistentes en ambientes nosocomiales, con una muestra de 646 pacientes en los que se aisló Klebsiella pneumoniae en un 27,11%, Pseudomonas aeruginosa en un 19%, seguida de Escherichia coli con un 16%, y Staphylococcus aureus con 4,75%. Discusión: Con 25 a 50% de las administraciones de antibióticos en hospitales consideradas irregulares, su uso indiscriminado y la lenta formulación de nuevas opciones terapéuticas, entre otras, contribuyeron al desarrollo de cepas bacterianas multirresistentes durante la era antimicrobiana. Los principales mecanismos de farmacorresistencia incluyen la modificación de antibióticos; prevenir la acción del antibiótico sobre su objetivo; alteración del sitio de unión primario; y producir un objetivo alternativo para eludir el efecto del fármaco. Consideraciones finales: La multirresistencia bacteriana aumenta la morbilidad y la mortalidad, la duración de la estancia hospitalaria y los gastos de suministros y personal especializado. Se estableció como un problema que tiende a agravarse con el tiempo, por lo que son necesarios estudios integrales enfocados en la prevalencia bacteriana para delinear estrategias de salud pública orientadas a su control.Introdução: Seres humanos convivem de modo comensal com inúmeras bactérias, porém espécies patogênicas assolaram a humanidade por milênios até o advento dos primeiros antibióticos. Entretanto, o uso indiscriminado de antibióticos, tanto em hospitais quanto na agropecuária, tem gerado altas taxas de resistência bacteriana e se tornado um problema com disrupção eminente. O presente estudo visa analisar a etiologia multifatorial dos mecanismos de multirresistência bacteriana, a prevalência das principais bactérias envolvidas nesse processo e seu impacto na saúde pública. Metodologia: Trata-se uma revisão integrativa de literatura acerca dos processos e consequências da resistência bacteriana. O critério de inclusão foi a compatibilidade com o tema e a relevância. Resultados: Analisados 46 artigos dos quais metade são artigos originais. Dentre estes, 6 artigos realizaram levantamento da prevalência de bactérias farmacorresistentes em ambientes nosocomiais, com amostragem de 646 pacientes nos quais foram isolados Klebsiella pneumoniae em 27,11%, Pseudomonas aeruginosa em 19%, seguida por Escherichia coli com 16%, e Staphylococcus aureus com 4,75%. Discussão: Com 25 a 50% das administrações antibióticas em hospitais consideradas irregulares, seu uso indiscriminado e a lenta formulação de novas opções terapêuticas, entre outros, contribuiu com o desenvolvimento de cepas bacterianas multirresistentes durante a era dos antimicrobianos. Os principais mecanismos de farmacorresistência incluem modificação antibiótica; impedimento da ação do antibiótico em seu alvo; alteração do sítio primário de ligação; e produção de alvo alternativo para burlar o efeito do fármaco. Considerações Finais: A multirresistência bacteriana aumenta a morbimortalidade, tempo de internação e gastos com insumos e equipe especializada. Estabeleceu-se como um problema que tende a agravar com o tempo, portanto, estudos abrangentes focados na prevalência bacteriana são necessários para traçar estratégias de saúde pública visando seu controle.Research, Society and Development2021-06-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1630310.33448/rsd-v10i6.16303Research, Society and Development; Vol. 10 No. 6; e58810616303Research, Society and Development; Vol. 10 Núm. 6; e58810616303Research, Society and Development; v. 10 n. 6; e588106163032525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/16303/14440Copyright (c) 2021 Juliana Jeanne Vieira de Carvalho; Felipe Gomes Boaventura; Anitha de Cássia Ribeiro da Silva; Rhuana Lima Ximenes; Luana Kamila Castilho Rodrigues; Diego Antônio de Almeida Nunes; Viviane Krominski Graça de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho, Juliana Jeanne Vieira deBoaventura, Felipe GomesSilva, Anitha de Cássia Ribeiro daXimenes, Rhuana LimaRodrigues, Luana Kamila CastilhoNunes, Diego Antônio de AlmeidaSouza, Viviane Krominski Graça de 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/16303Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:53.334231Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Multirresistant bacteria and their impacts on public health: A social responsability Bacterias multirresistentes y sus impactos en la salud pública: Una responsabilidade social Bactérias multirresistentes e seus impactos na saúde pública: Uma responsabilidade social |
title |
Multirresistant bacteria and their impacts on public health: A social responsability |
spellingShingle |
Multirresistant bacteria and their impacts on public health: A social responsability Carvalho, Juliana Jeanne Vieira de Bacterial Drug Resistance Bacterial Infections Public health. Farmacorresistencia bacteriana Infecciones bacterianas Salud pública. Farmacorresistência Bacteriana Infecções Bacterianas Saúde pública. |
title_short |
Multirresistant bacteria and their impacts on public health: A social responsability |
title_full |
Multirresistant bacteria and their impacts on public health: A social responsability |
title_fullStr |
Multirresistant bacteria and their impacts on public health: A social responsability |
title_full_unstemmed |
Multirresistant bacteria and their impacts on public health: A social responsability |
title_sort |
Multirresistant bacteria and their impacts on public health: A social responsability |
author |
Carvalho, Juliana Jeanne Vieira de |
author_facet |
Carvalho, Juliana Jeanne Vieira de Boaventura, Felipe Gomes Silva, Anitha de Cássia Ribeiro da Ximenes, Rhuana Lima Rodrigues, Luana Kamila Castilho Nunes, Diego Antônio de Almeida Souza, Viviane Krominski Graça de |
author_role |
author |
author2 |
Boaventura, Felipe Gomes Silva, Anitha de Cássia Ribeiro da Ximenes, Rhuana Lima Rodrigues, Luana Kamila Castilho Nunes, Diego Antônio de Almeida Souza, Viviane Krominski Graça de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Juliana Jeanne Vieira de Boaventura, Felipe Gomes Silva, Anitha de Cássia Ribeiro da Ximenes, Rhuana Lima Rodrigues, Luana Kamila Castilho Nunes, Diego Antônio de Almeida Souza, Viviane Krominski Graça de |
dc.subject.por.fl_str_mv |
Bacterial Drug Resistance Bacterial Infections Public health. Farmacorresistencia bacteriana Infecciones bacterianas Salud pública. Farmacorresistência Bacteriana Infecções Bacterianas Saúde pública. |
topic |
Bacterial Drug Resistance Bacterial Infections Public health. Farmacorresistencia bacteriana Infecciones bacterianas Salud pública. Farmacorresistência Bacteriana Infecções Bacterianas Saúde pública. |
description |
Introduction: Human beings coexist with numerous bacteria, but pathogenic species have plagued mankind for millennia until the advent of the first antibiotics. However, the indiscriminate use of antibiotics, both in hospitals and in agriculture, has generated high rates of bacterial resistance and has become a problem with imminent disruption. The present study aims to analyze the multifactorial etiology of bacterial multiresistance mechanisms, the prevalence of the main bacteria involved in this process and its impact on public health. Methodology: This is an integrative literature review about the processes and consequences of bacterial resistance. The inclusion criterion was compatibility with the theme and relevance. Results: 46 articles were analyzed, half of which are original articles. Among these, 6 articles carried out a survey of the prevalence of pharmacoresistant bacteria in nosocomial environments, with a sample of 646 patients in which Klebsiella pneumoniae was isolated in 27.11%, Pseudomonas aeruginosa in 19%, followed by Escherichia coli with 16%, and Staphylococcus aureus with 4.75%. Discussion: With 25 to 50% of antibiotic administrations in hospitals considered irregular, their indiscriminate use and the slow formulation of new therapeutic options, among others, contributed to the development of multidrug-resistant bacterial strains during the antimicrobial era. The main pharmacoresistance mechanisms include antibiotic modification; preventing the action of the antibiotic on its target; alteration of the primary binding site; and producing an alternative target to circumvent the drug's effect. Final Considerations: Bacterial multidrug resistance increases morbidity and mortality, length of hospital stay and expenses with supplies and specialized staff. It was established as a problem that tends to worsen over time, therefore, comprehensive studies focused on bacterial prevalence are necessary to outline public health strategies aimed at its control. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16303 10.33448/rsd-v10i6.16303 |
url |
https://rsdjournal.org/index.php/rsd/article/view/16303 |
identifier_str_mv |
10.33448/rsd-v10i6.16303 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16303/14440 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 6; e58810616303 Research, Society and Development; Vol. 10 Núm. 6; e58810616303 Research, Society and Development; v. 10 n. 6; e58810616303 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052750246182912 |