Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/11327 |
Resumo: | Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect. |
id |
UNIFEI_177c18459b4a371e3a71e1225573cd06 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/11327 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbitsEl uso de biomateriales y rosuvastatina tópica aumenta la angiogénesis de heridas quirúrgicas en conejosUso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhosPlatelet-rich plasmaPlatelet-rich fibrinStatinsHealingNeovascularization.Plasma rico en plaquetasFibrina rica en plaquetasEstatinasCicatrizaciónNeovascularización.Plasma rico em plaquetasFibrina rica em plaquetasEstatinasCicatrizaçãoNeovascularização.Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect.Se han realizado estudios para verificar los efectos de biomateriales como el plasma rico en plaquetas (PRP) y la fibrina rica en plaquetas (FRP) y su contribución al proceso de cicatrización de heridas al liberar factores de crecimiento que tienen propiedades de regeneración tisular. Muchas evidencias también son favorables al uso tópico de rosuvastatina (RSV) en lesiones cutáneas, al modificar positivamente el flujo sanguíneo del tejido basal. Sin embargo, no está claro si este efecto está involucrado en un aumento del flujo sanguíneo y, en consecuencia, en una mejora en el proceso de curación. En este sentido, el presente estudio analizó la cantidad de fibroblastos y el número de vasos en heridas inducidas experimentalmente en conejos tras el tratamiento con y sin asociación de biomateriales y RSV. La hipótesis es que el uso tópico de un fármaco hipolipemiante asociado con un biomaterial puede aumentar la cantidad de fibroblastos y la angiogénesis después de una lesión inducida experimentalmente, aumentando así la colagenización para producir una cicatriz más homogénea. Se encontró que la asociación de FRP y RSV promovió un efecto aditivo al aumentar significativamente la angiogénesis. Se encontró que la asociación de FRP y RSV promovió un efecto aditivo, aumentando la angiogénesis en un 135%. El uso de RSV solo también proporcionó un aumento del 77% en la cantidad de fibroblastos. Se concluyó que tanto el FRP como el RSV tienen buenos efectos curativos, por lo que la asociación entre ellos fue beneficiosa y demostró un posible efecto aditivo.Estudos têm sido realizados para verificar os efeitos de biomateriais, como o plasma rico em plaquetas (PRP) e a fibrina rica em plaquetas (FRP) e a sua contribuição para o processo de cicatrização de feridas por meio da liberação de fatores de crescimento que têm propriedades de indução de regeneração tecidual. Muitas evidências também se mostram favoráveis ao uso tópico da rosuvastatina (RSV) em lesões de pele, por modificar de forma positiva o fluxo sanguíneo basal tecidual. No entanto, não está claro se este efeito está envolvido no aumento do fluxo sanguíneo e por consequência uma melhora no processo cicatricial. Neste sentido, o presente estudo analisou a quantidade de fibroblastos e número de vasos em feridas induzidas experimentalmente em coelhos após tratamento com e sem associação dos biomateriais e RSV. A hipótese baseia-se que o uso tópico de um fármaco hipolipemiante associado a um biomaterial possa aumentar a quantidade de fibroblastos e angiogênese após lesão experimentalmente induzida, e com isso aumentando a colagenização para produção de uma cicatriz mais homogênea. Verificou-se que a associação da FRP e RSV promoveu um efeito aditivo aumentando em 135% a angiogênese. O uso da RSV isolada também proporcionou um aumento de 77% na quantidade de fibroblastos. Concluiu-se que tanto a FRP quanto a RSV possuem bons efeitos cicatrizantes, de tal forma que a associação entre elas foi benéfica e demonstrou um possível efeito aditivo.Research, Society and Development2021-01-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1132710.33448/rsd-v10i1.11327Research, Society and Development; Vol. 10 No. 1; e32510111327Research, Society and Development; Vol. 10 Núm. 1; e32510111327Research, Society and Development; v. 10 n. 1; e325101113272525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/11327/10574Copyright (c) 2021 Natália Gonzaga de Oliveira Ferreira; Yuri Ferreira Vicentini; Maria Rosa Santos Breda; Rosa Maria Barilli Nogueira; Gisele Alborguetti Nai; Cecília Laposy Santarémhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Natália Gonzaga de OliveiraVicentini, Yuri Ferreira Breda, Maria Rosa Santos Nogueira, Rosa Maria Barilli Nai, Gisele Alborguetti Santarém, Cecília Laposy2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11327Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:11.084452Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits El uso de biomateriales y rosuvastatina tópica aumenta la angiogénesis de heridas quirúrgicas en conejos Uso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhos |
title |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
spellingShingle |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits Ferreira, Natália Gonzaga de Oliveira Platelet-rich plasma Platelet-rich fibrin Statins Healing Neovascularization. Plasma rico en plaquetas Fibrina rica en plaquetas Estatinas Cicatrización Neovascularización. Plasma rico em plaquetas Fibrina rica em plaquetas Estatinas Cicatrização Neovascularização. |
title_short |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
title_full |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
title_fullStr |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
title_full_unstemmed |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
title_sort |
Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits |
author |
Ferreira, Natália Gonzaga de Oliveira |
author_facet |
Ferreira, Natália Gonzaga de Oliveira Vicentini, Yuri Ferreira Breda, Maria Rosa Santos Nogueira, Rosa Maria Barilli Nai, Gisele Alborguetti Santarém, Cecília Laposy |
author_role |
author |
author2 |
Vicentini, Yuri Ferreira Breda, Maria Rosa Santos Nogueira, Rosa Maria Barilli Nai, Gisele Alborguetti Santarém, Cecília Laposy |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Natália Gonzaga de Oliveira Vicentini, Yuri Ferreira Breda, Maria Rosa Santos Nogueira, Rosa Maria Barilli Nai, Gisele Alborguetti Santarém, Cecília Laposy |
dc.subject.por.fl_str_mv |
Platelet-rich plasma Platelet-rich fibrin Statins Healing Neovascularization. Plasma rico en plaquetas Fibrina rica en plaquetas Estatinas Cicatrización Neovascularización. Plasma rico em plaquetas Fibrina rica em plaquetas Estatinas Cicatrização Neovascularização. |
topic |
Platelet-rich plasma Platelet-rich fibrin Statins Healing Neovascularization. Plasma rico en plaquetas Fibrina rica en plaquetas Estatinas Cicatrización Neovascularización. Plasma rico em plaquetas Fibrina rica em plaquetas Estatinas Cicatrização Neovascularização. |
description |
Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11327 10.33448/rsd-v10i1.11327 |
url |
https://rsdjournal.org/index.php/rsd/article/view/11327 |
identifier_str_mv |
10.33448/rsd-v10i1.11327 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11327/10574 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 1; e32510111327 Research, Society and Development; Vol. 10 Núm. 1; e32510111327 Research, Society and Development; v. 10 n. 1; e32510111327 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052805065736192 |