Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits

Detalhes bibliográficos
Autor(a) principal: Ferreira, Natália Gonzaga de Oliveira
Data de Publicação: 2021
Outros Autores: Vicentini, Yuri Ferreira, Breda, Maria Rosa Santos, Nogueira, Rosa Maria Barilli, Nai, Gisele Alborguetti, Santarém, Cecília Laposy
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11327
Resumo: Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect.
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spelling Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbitsEl uso de biomateriales y rosuvastatina tópica aumenta la angiogénesis de heridas quirúrgicas en conejosUso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhosPlatelet-rich plasmaPlatelet-rich fibrinStatinsHealingNeovascularization.Plasma rico en plaquetasFibrina rica en plaquetasEstatinasCicatrizaciónNeovascularización.Plasma rico em plaquetasFibrina rica em plaquetasEstatinasCicatrizaçãoNeovascularização.Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect.Se han realizado estudios para verificar los efectos de biomateriales como el plasma rico en plaquetas (PRP) y la fibrina rica en plaquetas (FRP) y su contribución al proceso de cicatrización de heridas al liberar factores de crecimiento que tienen propiedades de regeneración tisular. Muchas evidencias también son favorables al uso tópico de rosuvastatina (RSV) en lesiones cutáneas, al modificar positivamente el flujo sanguíneo del tejido basal. Sin embargo, no está claro si este efecto está involucrado en un aumento del flujo sanguíneo y, en consecuencia, en una mejora en el proceso de curación. En este sentido, el presente estudio analizó la cantidad de fibroblastos y el número de vasos en heridas inducidas experimentalmente en conejos tras el tratamiento con y sin asociación de biomateriales y RSV. La hipótesis es que el uso tópico de un fármaco hipolipemiante asociado con un biomaterial puede aumentar la cantidad de fibroblastos y la angiogénesis después de una lesión inducida experimentalmente, aumentando así la colagenización para producir una cicatriz más homogénea. Se encontró que la asociación de FRP y RSV promovió un efecto aditivo al aumentar significativamente la angiogénesis. Se encontró que la asociación de FRP y RSV promovió un efecto aditivo, aumentando la angiogénesis en un 135%. El uso de RSV solo también proporcionó un aumento del 77% en la cantidad de fibroblastos. Se concluyó que tanto el FRP como el RSV tienen buenos efectos curativos, por lo que la asociación entre ellos fue beneficiosa y demostró un posible efecto aditivo.Estudos têm sido realizados para verificar os efeitos de biomateriais, como o plasma rico em plaquetas (PRP) e a fibrina rica em plaquetas (FRP) e a sua contribuição para o processo de cicatrização de feridas por meio da liberação de fatores de crescimento que têm propriedades de indução de regeneração tecidual. Muitas evidências também se mostram favoráveis ao uso tópico da rosuvastatina (RSV) em lesões de pele, por modificar de forma positiva o fluxo sanguíneo basal tecidual. No entanto, não está claro se este efeito está envolvido no aumento do fluxo sanguíneo e por consequência uma melhora no processo cicatricial. Neste sentido, o presente estudo analisou a quantidade de fibroblastos e número de vasos em feridas induzidas experimentalmente em coelhos após tratamento com e sem associação dos biomateriais e RSV. A hipótese baseia-se que o uso tópico de um fármaco hipolipemiante associado a um biomaterial possa aumentar a quantidade de fibroblastos e angiogênese após lesão experimentalmente induzida, e com isso aumentando a colagenização para produção de uma cicatriz mais homogênea. Verificou-se que a associação da FRP e RSV promoveu um efeito aditivo aumentando em 135% a angiogênese. O uso da RSV isolada também proporcionou um aumento de 77% na quantidade de fibroblastos. Concluiu-se que tanto a FRP quanto a RSV possuem bons efeitos cicatrizantes, de tal forma que a associação entre elas foi benéfica e demonstrou um possível efeito aditivo.Research, Society and Development2021-01-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1132710.33448/rsd-v10i1.11327Research, Society and Development; Vol. 10 No. 1; e32510111327Research, Society and Development; Vol. 10 Núm. 1; e32510111327Research, Society and Development; v. 10 n. 1; e325101113272525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/11327/10574Copyright (c) 2021 Natália Gonzaga de Oliveira Ferreira; Yuri Ferreira Vicentini; Maria Rosa Santos Breda; Rosa Maria Barilli Nogueira; Gisele Alborguetti Nai; Cecília Laposy Santarémhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Natália Gonzaga de OliveiraVicentini, Yuri Ferreira Breda, Maria Rosa Santos Nogueira, Rosa Maria Barilli Nai, Gisele Alborguetti Santarém, Cecília Laposy2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11327Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:11.084452Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
El uso de biomateriales y rosuvastatina tópica aumenta la angiogénesis de heridas quirúrgicas en conejos
Uso de biomateriais e rosuvastatina tópica aumenta angiogênese de feridas cirúrgicas em coelhos
title Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
spellingShingle Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
Ferreira, Natália Gonzaga de Oliveira
Platelet-rich plasma
Platelet-rich fibrin
Statins
Healing
Neovascularization.
Plasma rico en plaquetas
Fibrina rica en plaquetas
Estatinas
Cicatrización
Neovascularización.
Plasma rico em plaquetas
Fibrina rica em plaquetas
Estatinas
Cicatrização
Neovascularização.
title_short Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
title_full Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
title_fullStr Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
title_full_unstemmed Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
title_sort Use of biomaterials and topical rosuvastatin increases angiogenesis of surgical wounds in rabbits
author Ferreira, Natália Gonzaga de Oliveira
author_facet Ferreira, Natália Gonzaga de Oliveira
Vicentini, Yuri Ferreira
Breda, Maria Rosa Santos
Nogueira, Rosa Maria Barilli
Nai, Gisele Alborguetti
Santarém, Cecília Laposy
author_role author
author2 Vicentini, Yuri Ferreira
Breda, Maria Rosa Santos
Nogueira, Rosa Maria Barilli
Nai, Gisele Alborguetti
Santarém, Cecília Laposy
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Natália Gonzaga de Oliveira
Vicentini, Yuri Ferreira
Breda, Maria Rosa Santos
Nogueira, Rosa Maria Barilli
Nai, Gisele Alborguetti
Santarém, Cecília Laposy
dc.subject.por.fl_str_mv Platelet-rich plasma
Platelet-rich fibrin
Statins
Healing
Neovascularization.
Plasma rico en plaquetas
Fibrina rica en plaquetas
Estatinas
Cicatrización
Neovascularización.
Plasma rico em plaquetas
Fibrina rica em plaquetas
Estatinas
Cicatrização
Neovascularização.
topic Platelet-rich plasma
Platelet-rich fibrin
Statins
Healing
Neovascularization.
Plasma rico en plaquetas
Fibrina rica en plaquetas
Estatinas
Cicatrización
Neovascularización.
Plasma rico em plaquetas
Fibrina rica em plaquetas
Estatinas
Cicatrização
Neovascularização.
description Studies have been conducted to verify the effects of biomaterials such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) and their contribution to the wound healing process by releasing growth factors that have properties of tissue regeneration. Many evidences are also favorable to the topical use of rosuvastatin (RSV) in skin lesions, by positively modifying the basal tissue blood flow. However, it is unclear whether this effect is involved in increased blood flow and consequently an improvement in the healing process. In this sense, the present study analyzed the amount of fibroblasts and number of vessels in wounds experimentally induced in rabbits after treatment with and without association of biomaterials and RSV. The hypothesis is that the topical use of a lipid-lowering drug associated with a biomaterial may increase the amount of fibroblasts and angiogenesis after experimentally induced injury, thereby increasing collagenization to produce a more homogeneous scar. It was found that the association of PRF and RSV promoted an additive effect, increasing angiogenesis by 135%. The use of RSV alone also provided a 77% increase in the amount of fibroblasts. It was concluded that both PRF and RSV have good healing effects, such that the association between them was beneficial and demonstrated a possible additive effect.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11327
10.33448/rsd-v10i1.11327
url https://rsdjournal.org/index.php/rsd/article/view/11327
identifier_str_mv 10.33448/rsd-v10i1.11327
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11327/10574
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 1; e32510111327
Research, Society and Development; Vol. 10 Núm. 1; e32510111327
Research, Society and Development; v. 10 n. 1; e32510111327
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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